concept

KIAA1549

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIAA1549: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

27Outgoing

12Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	KIAA1549
Key Genes/Proteins	BRAF, CDK1, MAPK
Related Diseases	Senescence, Tumor, Ms, Glioma, PILOCYTIC_ASTROCYTOMA
Related Pathways	MAPK, Mapk

Wiki Pages (2)

Knowledge base pages for this entity

BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase

gene · 1422 words

→

B-Raf Protein

protein · 653 words

→

Pathway Diagram

graph TD
    KIAA1549["KIAA1549"]
    KIAA1549 -->|"interacts"| BRAF["BRAF"]
    KIAA1549 -->|"target for"| Senescence["Senescence"]
    KIAA1549 -->|"target for"| Tumor["Tumor"]
    KIAA1549 -->|"target for"| Ms["Ms"]
    KIAA1549 -->|"target for"| Glioma["Glioma"]
    BRAF -->|"target for"| KIAA1549
    CDK1["CDK1"] -->|"target for"| KIAA1549
    IRS1["IRS1"] -->|"target for"| KIAA1549
    KIAA1549__BRAF["KIAA1549::BRAF"] -->|"inhibits"| KIAA1549
    MEK["MEK"] -->|"inhibits"| KIAA1549

Outgoing (27)

Target	Relation	Type	Str
BRAF	interacts_with	gene	0.72
Senescence	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioma	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Tumor	inhibits	disease	0.65
Senescence	causes	disease	0.65
MAPK	activates	pathway	0.64
PILOCYTIC_ASTROCYTOMA	associated_with	disease	0.64
Mapk	therapeutic_target	pathway	0.60
Mapk	regulates	pathway	0.60
CDK1	regulates	gene	0.60
BRAF	inhibits	gene	0.60
MAPK	regulates	gene	0.60
RNA	inhibits	gene	0.60
IRS1	regulates	gene	0.60
AND	inhibits	gene	0.60
MEK	inhibits	gene	0.60
IRS1	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
BRAF	therapeutic_target	gene	0.60
Raf	therapeutic_target	protein	0.60
Fus	therapeutic_target	protein	0.60
App	therapeutic_target	protein	0.60
senescence	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60

Incoming (12)

Source	Relation	Type	Str
BRAF	therapeutic_target	gene	0.60
CDK1	therapeutic_target	gene	0.60
IRS1	therapeutic_target	gene	0.60
BRAF	inhibits	gene	0.60
IRS1	regulates	gene	0.60
CDK1	regulates	gene	0.60
KIAA1549::BRAF	inhibits	gene	0.60
MEK	inhibits	gene	0.60
RNA	inhibits	gene	0.60
MAPK	regulates	gene	0.60
BRAF	regulates	gene	0.60
CK2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found