CK2

Understanding Entity Pages

This page aggregates everything SciDEX knows about CK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CK2 (Casein Kinase 2) is a constitutively active serine/threonine protein kinase that phosphorylates over 300 substrates involved in transcription, translation, cell cycle, and cell survival. It is implicated in Alzheimer's disease tau pathology and cancer.

View on Wiki →

flowchart TD
    N0["CK2"]
    N1["Notch Signaling"]
    N0 -->|"regulates"| N1
    N2["MYH9"]
    N0 -->|"phosphorylates"| N2
    N3["E(SPL)M8"]
    N0 -->|"phosphorylates"| N3
    N4["Neurogenesis"]
    N4 -->|"involved in"| N0
    N5["KIF5"]
    N0 -->|"phosphorylates"| N5
    N6["PP2A"]
    N0 -->|"interacts with"| N6
    N7["MAPK"]
    N7 -->|"regulates"| N0
    N8["BRAF"]
    N8 -->|"activates"| N0
    N9["CDK1"]
    N9 -->|"co discussed"| N0
    N7 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 pathway
    class N2 protein
    class N3 protein
    class N5 protein
    class N7 pathway
    class N8 gene
    class N9 gene