Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LMX1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LMX1B |
| Chromosome | 9q33.3 |
| Protein Type | Transcription Factor |
| Function | encodes a critical transcription factor required for the proper development and maintenance of dopaminergic neurons in the midbrain. |
| Molecular Weight | ~41 kDa |
| Amino Acids | 372 aa |
| Exons | 5 |
| Pathways | Alpha-Synuclein, Er Stress, Synaptic Plasticity |
| UniProt ID | O43823 |
| NCBI Gene ID | 4010 |
| Ensembl ID | ENSG00000136944 |
| OMIM | 602575 |
| GeneCards | LMX1B |
| Human Protein Atlas | LMX1B |
| Feature | Details |
| Associated Diseases | Parkinson |
| KG Connections | 35 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
LMX1B["<b>LMX1B</b>"]
Parkinson["Parkinson"]
LMX1B -->|"regulates"| Parkinson
NURR1["NURR1"]
LMX1B -->|"associated with"| NURR1
SNCA["SNCA"]
LMX1B -->|"regulates"| SNCA
PARKINSON["PARKINSON"]
LMX1B -->|"regulates"| PARKINSON
Er_Stress["Er Stress"]
LMX1B -->|"regulates"| Er_Stress
Synaptic_Plasticity["Synaptic Plasticity"]
LMX1B -->|"regulates"| Synaptic_Plasticity
Dopaminergic["Dopaminergic"]
LMX1B -->|"associated with"| Dopaminergic
PINK1["PINK1"]
LMX1B -->|"regulates"| PINK1
SFPQ["SFPQ"]
LMX1B -->|"regulates"| SFPQ
DJ_1["DJ-1"]
LMX1B -->|"regulates"| DJ_1
AND["AND"]
LMX1B -->|"associated with"| AND
NFM["NFM"]
LMX1B -->|"regulates"| NFM
HNRNPA1["HNRNPA1"]
LMX1B -->|"regulates"| HNRNPA1
PGC1ALPHA["PGC1ALPHA"]
LMX1B -->|"regulates"| PGC1ALPHA
PARK7["PARK7"]
LMX1B -->|"regulates"| PARK7
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
LMX1B -->|"regulates"| PARKINSON_S_DISEASE
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
LMX1B -->|"regulates"| ALPHA_SYNUCLEIN
Alpha_Synuclein["Alpha-Synuclein"]
LMX1B -->|"regulates"| Alpha_Synuclein
HNRNPA1["HNRNPA1"]
HNRNPA1 -->|"regulates"| LMX1B
PARK7["PARK7"]
PARK7 -->|"regulates"| LMX1B
PINK1["PINK1"]
PINK1 -->|"regulates"| LMX1B
NFM["NFM"]
NFM -->|"regulates"| LMX1B
DJ_1["DJ-1"]
DJ_1 -->|"regulates"| LMX1B
neurodegeneration["neurodegeneration"]
LMX1B -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| dI5 neurons | expressed_in | cell_type | 0.95 |
| glutamatergic neuron identity | drives | phenotype | 0.85 |
| ZFHX3 | associated_with | gene | 0.75 |
| Parkinson | regulates | disease | 0.65 |
| NURR1 | associated_with | gene | 0.60 |
| SNCA | regulates | gene | 0.60 |
| PINK1 | regulates | gene | 0.60 |
| SFPQ | regulates | gene | 0.60 |
| NFM | regulates | gene | 0.60 |
| HNRNPA1 | regulates | gene | 0.60 |
| PGC1ALPHA | regulates | gene | 0.60 |
| PARK7 | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| Er Stress | regulates | pathway | 0.60 |
| Synaptic Plasticity | regulates | pathway | 0.60 |
| Dopaminergic | associated_with | cell_type | 0.60 |
| DJ-1 | regulates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| ALPHA-SYNUCLEIN | regulates | gene | 0.60 |
| Alpha-Synuclein | regulates | pathway | 0.60 |
| App | regulates | protein | 0.60 |
| Parkinson | associated_with | disease | 0.60 |
| NFM | co_expressed_with | gene | 0.50 |
| NURR1 | co_expressed_with | gene | 0.50 |
| DOPAMINERGIC | associated_with | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||