gene

LMX1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LMX1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections
0Hypotheses
0Analyses
26Outgoing
9Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolLMX1B
Chromosome9q33.3
Protein TypeTranscription Factor
Functionencodes a critical transcription factor required for the proper development and maintenance of dopaminergic neurons in the midbrain.
Molecular Weight~41 kDa
Amino Acids372 aa
Exons5
PathwaysAlpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt IDO43823
NCBI Gene ID4010
Ensembl IDENSG00000136944
OMIM602575
GeneCardsLMX1B
Human Protein AtlasLMX1B
FeatureDetails
Associated DiseasesParkinson
KG Connections35 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: LMX1B — AlphaFold O43823 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

lmx1b

gene · 3191 words

PGC-1α (PPARGC1A)

protein · 2474 words

NFM — Neurofilament Medium Chain

gene · 2470 words

Pre-Bötzinger Complex - Expanded

cell · 1764 words

POU3F2 — POU Class 3 Homeobox 2

gene · 1755 words

Median Raphe Serotonergic Neurons

cell · 1668 words

Pathway Diagram

graph TD
    LMX1B["<b>LMX1B</b>"]
    Parkinson["Parkinson"]
    LMX1B -->|"regulates"| Parkinson
    NURR1["NURR1"]
    LMX1B -->|"associated with"| NURR1
    SNCA["SNCA"]
    LMX1B -->|"regulates"| SNCA
    PARKINSON["PARKINSON"]
    LMX1B -->|"regulates"| PARKINSON
    Er_Stress["Er Stress"]
    LMX1B -->|"regulates"| Er_Stress
    Synaptic_Plasticity["Synaptic Plasticity"]
    LMX1B -->|"regulates"| Synaptic_Plasticity
    Dopaminergic["Dopaminergic"]
    LMX1B -->|"associated with"| Dopaminergic
    PINK1["PINK1"]
    LMX1B -->|"regulates"| PINK1
    SFPQ["SFPQ"]
    LMX1B -->|"regulates"| SFPQ
    DJ_1["DJ-1"]
    LMX1B -->|"regulates"| DJ_1
    AND["AND"]
    LMX1B -->|"associated with"| AND
    NFM["NFM"]
    LMX1B -->|"regulates"| NFM
    HNRNPA1["HNRNPA1"]
    LMX1B -->|"regulates"| HNRNPA1
    PGC1ALPHA["PGC1ALPHA"]
    LMX1B -->|"regulates"| PGC1ALPHA
    PARK7["PARK7"]
    LMX1B -->|"regulates"| PARK7
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    LMX1B -->|"regulates"| PARKINSON_S_DISEASE
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    LMX1B -->|"regulates"| ALPHA_SYNUCLEIN
    Alpha_Synuclein["Alpha-Synuclein"]
    LMX1B -->|"regulates"| Alpha_Synuclein
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"regulates"| LMX1B
    PARK7["PARK7"]
    PARK7 -->|"regulates"| LMX1B
    PINK1["PINK1"]
    PINK1 -->|"regulates"| LMX1B
    NFM["NFM"]
    NFM -->|"regulates"| LMX1B
    DJ_1["DJ-1"]
    DJ_1 -->|"regulates"| LMX1B
    neurodegeneration["neurodegeneration"]
    LMX1B -->|"implicated in"| neurodegeneration

Outgoing (26)

TargetRelationTypeStr
dI5 neuronsexpressed_incell_type0.95
glutamatergic neuron identitydrivesphenotype0.85
ZFHX3associated_withgene0.75
Parkinsonregulatesdisease0.65
NURR1associated_withgene0.60

Incoming (9)

SourceRelationTypeStr
HNRNPA1regulatesgene0.60
PARK7regulatesgene0.60
PINK1regulatesgene0.60
NFMregulatesgene0.60
PGC1ALPHAregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found