gene

NFM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections
0Hypotheses
0Analyses
27Outgoing
24Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolNEFM
Full NameNeurofilament Medium Chain
AliasesNFM
Chromosome8p21.2
Protein FamilyIntermediate filament family
Functionis a neuronal intermediate filament protein encoded by the NEFM gene on chromosome 8p21, adjacent to the NEFL gene.
Primary ExpressionAxon, neuronal cytoplasm
Amino Acids916 aa
Exons10
PathwaysAlpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt IDP12036
NCBI Gene ID4741
Ensembl IDENSG00000104722
GeneCardsNEFM
Human Protein AtlasNEFM
Associated DiseasesParkinson
InteractionsNPY, POMC, PRKN, RBFOX3, RNA, AIF1
KG Connections51 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NFM — AlphaFold P12036 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Neurofilament Medium Chain (NfM) - Biomarker

biomarker · 1432 words

Cerebrospinal Fluid (CSF) Biomarkers Overview

biomarker · 4101 words

msa-cure-roadmap

mechanism · 2780 words

SLC16A2 Gene (MCT8)

gene · 2721 words

NfL-Guided Neuroprotection Threshold

idea · 2577 words

Axonal Spheroids in Neurodegeneration

mechanism · 2547 words

Pathway Diagram

graph TD
    NFM["<b>NFM</b>"]
    Parkinson["Parkinson"]
    NFM -->|"regulates"| Parkinson
    DJ_1["DJ-1"]
    NFM -->|"regulates"| DJ_1
    LMX1B["LMX1B"]
    NFM -->|"regulates"| LMX1B
    NURR1["NURR1"]
    NFM -->|"regulates"| NURR1
    SNCA["SNCA"]
    NFM -->|"regulates"| SNCA
    PARKINSON["PARKINSON"]
    NFM -->|"regulates"| PARKINSON
    Er_Stress["Er Stress"]
    NFM -->|"regulates"| Er_Stress
    Synaptic_Plasticity["Synaptic Plasticity"]
    NFM -->|"regulates"| Synaptic_Plasticity
    Dopaminergic["Dopaminergic"]
    NFM -->|"regulates"| Dopaminergic
    HNRNPA1["HNRNPA1"]
    NFM -->|"associated with"| HNRNPA1
    PGC1ALPHA["PGC1ALPHA"]
    NFM -->|"regulates"| PGC1ALPHA
    PARK7["PARK7"]
    NFM -->|"regulates"| PARK7
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    NFM -->|"regulates"| PARKINSON_S_DISEASE
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    NFM -->|"regulates"| ALPHA_SYNUCLEIN
    Alpha_Synuclein["Alpha-Synuclein"]
    NFM -->|"regulates"| Alpha_Synuclein
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"associated with"| NFM
    PARK7["PARK7"]
    PARK7 -->|"regulates"| NFM
    PINK1["PINK1"]
    PINK1 -->|"regulates"| NFM
    LMX1B["LMX1B"]
    LMX1B -->|"regulates"| NFM
    PARKINSON["PARKINSON"]
    PARKINSON -->|"regulates"| NFM
    SNCA["SNCA"]
    SNCA -->|"regulates"| NFM
    SFPQ["SFPQ"]
    SFPQ -->|"regulates"| NFM
    DJ_1["DJ-1"]
    DJ_1 -->|"regulates"| NFM
    AND["AND"]
    AND -->|"associated with"| NFM
    neurodegeneration["neurodegeneration"]
    NFM -->|"implicated in"| neurodegeneration

Outgoing (27)

TargetRelationTypeStr
Parkinsonregulatesdisease0.65
LMX1Bregulatesgene0.60
NURR1regulatesgene0.60
SNCAregulatesgene0.60
HNRNPA1associated_withgene0.60

Incoming (24)

SourceRelationTypeStr
HNRNPA1associated_withgene0.60
PARK7regulatesgene0.60
PINK1regulatesgene0.60
LMX1Bregulatesgene0.60
SNCAregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found