Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NFM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NEFM |
| Full Name | Neurofilament Medium Chain |
| Aliases | NFM |
| Chromosome | 8p21.2 |
| Protein Family | Intermediate filament family |
| Function | is a neuronal intermediate filament protein encoded by the NEFM gene on chromosome 8p21, adjacent to the NEFL gene. |
| Primary Expression | Axon, neuronal cytoplasm |
| Amino Acids | 916 aa |
| Exons | 10 |
| Pathways | Alpha-Synuclein, Er Stress, Synaptic Plasticity |
| UniProt ID | P12036 |
| NCBI Gene ID | 4741 |
| Ensembl ID | ENSG00000104722 |
| GeneCards | NEFM |
| Human Protein Atlas | NEFM |
| Associated Diseases | Parkinson |
| Interactions | NPY, POMC, PRKN, RBFOX3, RNA, AIF1 |
| KG Connections | 51 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NFM["<b>NFM</b>"]
Parkinson["Parkinson"]
NFM -->|"regulates"| Parkinson
DJ_1["DJ-1"]
NFM -->|"regulates"| DJ_1
LMX1B["LMX1B"]
NFM -->|"regulates"| LMX1B
NURR1["NURR1"]
NFM -->|"regulates"| NURR1
SNCA["SNCA"]
NFM -->|"regulates"| SNCA
PARKINSON["PARKINSON"]
NFM -->|"regulates"| PARKINSON
Er_Stress["Er Stress"]
NFM -->|"regulates"| Er_Stress
Synaptic_Plasticity["Synaptic Plasticity"]
NFM -->|"regulates"| Synaptic_Plasticity
Dopaminergic["Dopaminergic"]
NFM -->|"regulates"| Dopaminergic
HNRNPA1["HNRNPA1"]
NFM -->|"associated with"| HNRNPA1
PGC1ALPHA["PGC1ALPHA"]
NFM -->|"regulates"| PGC1ALPHA
PARK7["PARK7"]
NFM -->|"regulates"| PARK7
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
NFM -->|"regulates"| PARKINSON_S_DISEASE
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
NFM -->|"regulates"| ALPHA_SYNUCLEIN
Alpha_Synuclein["Alpha-Synuclein"]
NFM -->|"regulates"| Alpha_Synuclein
HNRNPA1["HNRNPA1"]
HNRNPA1 -->|"associated with"| NFM
PARK7["PARK7"]
PARK7 -->|"regulates"| NFM
PINK1["PINK1"]
PINK1 -->|"regulates"| NFM
LMX1B["LMX1B"]
LMX1B -->|"regulates"| NFM
PARKINSON["PARKINSON"]
PARKINSON -->|"regulates"| NFM
SNCA["SNCA"]
SNCA -->|"regulates"| NFM
SFPQ["SFPQ"]
SFPQ -->|"regulates"| NFM
DJ_1["DJ-1"]
DJ_1 -->|"regulates"| NFM
AND["AND"]
AND -->|"associated with"| NFM
neurodegeneration["neurodegeneration"]
NFM -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | regulates | disease | 0.65 |
| LMX1B | regulates | gene | 0.60 |
| NURR1 | regulates | gene | 0.60 |
| SNCA | regulates | gene | 0.60 |
| HNRNPA1 | associated_with | gene | 0.60 |
| PGC1ALPHA | regulates | gene | 0.60 |
| PARK7 | regulates | gene | 0.60 |
| PINK1 | regulates | gene | 0.60 |
| NPY | activates | gene | 0.60 |
| POMC | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| RBFOX3 | activates | gene | 0.60 |
| DJ-1 | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| Er Stress | regulates | pathway | 0.60 |
| Synaptic Plasticity | regulates | pathway | 0.60 |
| Dopaminergic | regulates | cell_type | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| ALPHA-SYNUCLEIN | regulates | gene | 0.60 |
| Alpha-Synuclein | regulates | pathway | 0.60 |
| App | regulates | protein | 0.60 |
| Parkinson | associated_with | disease | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| RNA | activates | gene | 0.60 |
| NURR1 | co_expressed_with | gene | 0.50 |
| PARK7 | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HNRNPA1 | associated_with | gene | 0.60 |
| PARK7 | regulates | gene | 0.60 |
| PINK1 | regulates | gene | 0.60 |
| LMX1B | regulates | gene | 0.60 |
| SNCA | regulates | gene | 0.60 |
| SFPQ | regulates | gene | 0.60 |
| PGC1ALPHA | regulates | gene | 0.60 |
| NURR1 | regulates | gene | 0.60 |
| AIF1 | activates | gene | 0.60 |
| ARC | activates | gene | 0.60 |
| CAMKK2 | activates | gene | 0.60 |
| COX4I1 | activates | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| IBA1 | activates | gene | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| NEFM | activates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| DJ-1 | regulates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| HNRNPA1 | co_expressed_with | gene | 0.50 |
| LMX1B | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||