MAP3K4

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP3K4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MAP3K4 encodes a key upstream kinase regulating stress-activated MAPK pathways (JNK, p38). Implicated in Alzheimer's disease, Parkinson's disease, and ALS through stress response signaling and neuronal survival.

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graph TD
    MAP3K4["<b>MAP3K4</b>"]
    Neurodegeneration{"Neurodegeneration"}
    MAP3K4 -->|"regulates"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    MAP3K4 -->|"regulates"| Alzheimer
    MAP3K4 -->|"activates"| Alzheimer
    MAP3K4 -->|"activates"| Neurodegeneration
    Ms{"Ms"}
    MAP3K4 -->|"regulates"| Ms
    Nf__b(["Nf-Kappab"])
    MAP3K4 -->|"regulates"| Nf__b
    GADD45G["GADD45G"]
    MAP3K4 -->|"regulates"| GADD45G
    DNA["DNA"]
    MAP3K4 -->|"regulates"| DNA
    IRF3["IRF3"]
    MAP3K4 -->|"regulates"| IRF3
    REL["REL"]
    MAP3K4 -->|"regulates"| REL
    ASTROCYTES["ASTROCYTES"]
    MAP3K4 -->|"regulates"| ASTROCYTES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    MAP3K4 -->|"regulates"| ALZHEIMER_S_DISEASE
    IRF3 -->|"regulates"| MAP3K4
    HDAC6["HDAC6"]
    HDAC6 -->|"regulates"| MAP3K4
    NF__B["NF-KappaB"]
    NF__B -->|"regulates"| MAP3K4
    ASTROCYTES -->|"regulates"| MAP3K4
    ALZHEIMER_S_DISEASE -->|"regulates"| MAP3K4
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| MAP3K4
    AND["AND"]
    AND -->|"regulates"| MAP3K4
    DNA -->|"regulates"| MAP3K4
    NEURON["NEURON"]
    NEURON -->|"regulates"| MAP3K4
    SYNAPSE["SYNAPSE"]
    SYNAPSE -->|"regulates"| MAP3K4
    GADD45G -->|"regulates"| MAP3K4
    style MAP3K4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0