gene

REL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

3Hypotheses

30Analyses

50Outgoing

49Incoming

Summary

REL is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, expressed in. Associated with AD, ALI, AMI. Connected to 114 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	REL
Full Name	c-Rel Proto-Oncogene, NF-Kappa B Subunit
Chromosome	2p16.1
Function	REL (c-Rel) is a member of the NF-κB family that forms heterodimers with p50 and p52.
Primary Expression	hematopoietic cells, with lower expression in other tissues
Pathways	Akt, Apoptosis, Complement, Immune Response, Lipid Metabolism
UniProt ID	P41160
NCBI Gene ID	5966
Ensembl ID	ENSG00000162924
OMIM	164913
GeneCards	REL
Human Protein Atlas	REL
Associated Diseases	AD, ALI, AMI, Aging, Als, Inflammation
Interactions	FOXO1, CANCER, GENES, AND, IL-10, RNA
KG Connections	152 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: REL — AlphaFold P41160 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Pathway Diagram

graph TD
    REL["REL"] -->|"regulates"| Ms["Ms"]
    REL["REL"] -->|"regulates"| Inflammation["Inflammation"]
    REL["REL"] -->|"expressed in"| Lymphoma["Lymphoma"]
    REL["REL"] -->|"expressed in"| Als["Als"]
    REL["REL"] -->|"expressed in"| Ms_1["Ms"]
    REL["REL"] -->|"regulates"| Alzheimer["Alzheimer"]
    CERS2["CERS2"] -->|"regulates"| REL["REL"]
    CERS2_2["CERS2"] -->|"associated"| REL["REL"]
    CDKN2A["CDKN2A"] -->|"regulates"| REL["REL"]
    TP53["TP53"] -->|"regulates"| REL["REL"]
    style REL fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (103)

Target	Relation	Type	Str
INSC	regulates	gene	0.95
Als	activates	disease	0.85
Inflammation	regulates	disease	0.75
Als	regulates	disease	0.75
Cancer	activates	disease	0.75
Immune Response	regulates	pathway	0.70
Ms	regulates	disease	0.65
Lymphoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Obesity	regulates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Cancer	contributes_to	disease	0.65
Carcinoma	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Ms	causes	disease	0.65
Alzheimer	protects_against	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Stroke	protects_against	disease	0.65
Aging	associated_with	disease	0.65
PRDM1	regulates	gene	0.60
CD8	regulates	gene	0.60
STAT3	associated_with	gene	0.60
IRF1	associated_with	gene	0.60
FOXO1	activates	gene	0.60
CERS2	regulates	gene	0.60
RELA	expressed_in	gene	0.60
RELB	expressed_in	gene	0.60
RELA	contributes_to	gene	0.60
RELA	therapeutic_target	gene	0.60
RELB	therapeutic_target	gene	0.60
CD4	regulates	gene	0.60
CERS2	causes	gene	0.60
Rb	regulates	protein	0.60
Lipid Metabolism	regulates	pathway	0.60
Sphingolipid	regulates	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60
Sphingolipid	associated_with	pathway	0.60
Apoptosis	expressed_in	pathway	0.60

Incoming (49)

Source	Relation	Type	Str
INFLAMMATION	regulates	gene	0.70
CERS2	regulates	gene	0.60
CERS2	associated_with	gene	0.60
CDKN2A	regulates	gene	0.60
TP53	regulates	gene	0.60
TET2	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
KMT2D	expressed_in	gene	0.60
STAT3	regulates	gene	0.60
DDX3X	expressed_in	gene	0.60
RB1	regulates	gene	0.60
GNA13	expressed_in	gene	0.60
HDAC6	regulates	gene	0.60
MAP3K4	regulates	gene	0.60
CD4	regulates	gene	0.60
MTOR	regulates	gene	0.60
IL6	regulates	gene	0.60
TP53	activates	gene	0.60
MYC	activates	gene	0.60
SOD2	regulates	gene	0.60
AKT	regulates	gene	0.60
HIF1A	activates	gene	0.60
HRAS	regulates	gene	0.60
PPARG	activates	gene	0.60
GAPDH	regulates	gene	0.60
BCL2L1	activates	gene	0.60
TBK1	activates	gene	0.60
NF-ΚB	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
NFKB	regulates	gene	0.60
ERBB2	regulates	gene	0.60
KRAS	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NF-KB	expressed_in	gene	0.60
NF-ΚB	interacts_with	gene	0.60
CYTOKINES	activates	gene	0.60
NF-ΚB	contributes_to	gene	0.60
INFLAMMATION	activates	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
IL-10	activates	gene	0.60
AND	activates	gene	0.60
INSC	regulates	gene	0.60
RNA	inhibits	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	protects_against	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.569	neurodegeneration	Lipid raft composition changes in synapt
Senescent Cell Mitochondrial DNA Release	0.545	neurodegeneration	Senolytic therapy for age-related neurod

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757]	["Bi D", "Yang X", "Wang Y", "Yong J", "	Frontiers in immunology	2026	0
Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577]	["Zhou R", "Lin X", "Liao Z", "Lin J", "	Ageing research reviews	2026	0
Role of NEIL1 in genome maintenance. [PMID:40010204]	["McCullough A", "Minko I", "Luzadder M"	DNA repair	2025	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808]	["Lai P", "Liu L", "Bancaro N", "Troiani	Immunity	2025	0
Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559]	["Akgun Y"]	Ageing research reviews	2025	0
Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226]	["Daubermann C", "Herhaus B", "Neuberger	Molecular biology reports	2025	0
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587]	["Song Z", "Xie X", "Chen Y", "Zhang B",	Immunity	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Antileukemic potential of methylated indolequinone MAC681 through immunogenic ne [PMID:38704604]	["Orlikova-Boyer B", "Lorant A", "Gajula	Biomarker research	2024	0
Enhancing Radiofrequency Ablation for Hepatocellular Carcinoma: Nano-Epidrug Eff [PMID:39548919]	["Li X", "Liu Y", "Ke J", "Wang Z", "Han	Advanced materials (Deerfield	2024	0
The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellul [PMID:39490400]	Zhang Y, Zou M, Wu H, Zhu J, Jin T	Neurobiology of disease	2024	0
mtDNA release promotes cGAS-STING activation and accelerated aging of postmitoti [PMID:39039044]	["Li Y", "Cui J", "Liu L", "Hambright W"	Cell death & disease	2024	0
Senescent glia link mitochondrial dysfunction and lipid accumulation. [PMID:38839958]	["Byrns C", "Perlegos A", "Miller K", "J	Nature	2024	0
Apoptotic stress causes mtDNA release during senescence and drives the SASP. [PMID:37821702]	["Victorelli S", "Salmonowicz H", "Chapm	Nature	2023	0
Exposome and unhealthy aging: environmental drivers from air pollution to occupa [PMID:37688657]	Pandics T, Major D, Fazekas-Pongor V, Sz	GeroScience	2023	0
cGAS-STING drives ageing-related inflammation and neurodegeneration. [PMID:37532932]	Gulen MF, Samson N, Keller A, Schwabenla	Nature	2023	0
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STI [PMID:36964253]	["Kim J", "Kim H", "Chung J"]	Experimental & molecular medic	2023	0
The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse [PMID:37633968]	["Jiang S", "Tian T", "Yao H", "Xia X",	Cell death and differentiation	2023	0

REL

Understanding Entity Pages

Summary

Wiki Pages (21)

REL Gene

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

PI-2620 Tau PET in PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

NRF2 Oxidative Stress Pathway

Pathway Diagram

Outgoing (103)

Incoming (49)

Targeting Hypotheses (3)

Mentioning Analyses (30)

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

How does APOE4's beneficial immune function reconcile with its established role

How do P/Q channel deficits paradoxically increase thalamic excitability despite

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

What is the temporal sequence of sleep disruption versus amyloid-beta accumulati

What is the optimal ketone dosing threshold to avoid metabolic steal syndrome wh

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

Does tau aggregation specifically cause PS externalization in vesicles independe

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

Does TFEB dysfunction causally drive neurodegeneration or represent compensatory

What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie

Why do clinical manifestations overlap despite distinct underlying etiologies in

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Can circadian interventions reverse microglial priming independent of sleep disr

What are the specific pathophysiological mechanisms underlying uncommon immune-m

What determines the specificity of DDR protein recruitment to dilncRNA-induced c

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What are the specific molecular mechanisms by which C1Q components drive atheros

What is the optimal therapeutic window timing for autophagy enhancement versus s

Related Papers (20)