GADD45G

Understanding Entity Pages

This page aggregates everything SciDEX knows about GADD45G: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive information about GADD45G, its role in stress response, DNA repair, apoptosis, and implications for Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

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graph TD
    GADD45G["<b>GADD45G</b>"]
    reactive_gliosis["reactive_gliosis"]
    GADD45G -->|"activates"| reactive_gliosis
    neurodegeneration["neurodegeneration"]
    GADD45G -->|"activates"| neurodegeneration
    astrocytes["astrocytes"]
    GADD45G -->|"expressed in"| astrocytes
    Neurodegeneration{"Neurodegeneration"}
    GADD45G -->|"activates"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    GADD45G -->|"expressed in"| Alzheimer
    Ms{"Ms"}
    GADD45G -->|"activates"| Ms
    Depression{"Depression"}
    GADD45G -->|"inhibits"| Depression
    GADD45G -->|"expressed in"| Ms
    astrogliosis["astrogliosis"]
    GADD45G -->|"causes"| astrogliosis
    microgliosis["microgliosis"]
    GADD45G -->|"causes"| microgliosis
    synapse_loss["synapse_loss"]
    GADD45G -->|"causes"| synapse_loss
    alzheimer_disease{"alzheimer_disease"}
    GADD45G -->|"activates"| alzheimer_disease
    IRF3["IRF3"]
    IRF3 -->|"regulates"| GADD45G
    GADD45A["GADD45A"]
    GADD45A -->|"activates"| GADD45G
    GADD45B["GADD45B"]
    GADD45B -->|"activates"| GADD45G
    GADD45A -->|"regulates"| GADD45G
    GADD45B -->|"regulates"| GADD45G
    MAP3K4["MAP3K4"]
    MAP3K4 -->|"regulates"| GADD45G
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| GADD45G
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"expressed in"| GADD45G
    NF__B["NF-KappaB"]
    NF__B -->|"regulates"| GADD45G
    DNA["DNA"]
    DNA -->|"activates"| GADD45G
    NEURON["NEURON"]
    NEURON -->|"regulates"| GADD45G
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"expressed in"| GADD45G
    style GADD45G fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0