SLC2A1

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC2A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SLC2A1 encodes GLUT1, the principal glucose transporter at the blood-brain barrier. Critical for brain energy metabolism, GLUT1 dysfunction contributes to Alzheimer's disease, Parkinson's disease, and GLUT1 deficiency syndrome. Essential for neuronal glucose uptake and metabolic homeostasis.

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graph TD
    SLC2A1["<b>SLC2A1</b>"]
    GLUT1["GLUT1"]
    SLC2A1 -->|"encodes"| GLUT1
    Cancer{"Cancer"}
    SLC2A1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    SLC2A1 -->|"inhibits"| Tumor
    Ms{"Ms"}
    SLC2A1 -->|"therapeutic target"| Ms
    SLC2A1 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    SLC2A1 -->|"associated with"| Parkinson
    SLC2A1 -->|"associated with"| Cancer
    SLC2A1 -->|"associated with"| Tumor
    Carcinoma{"Carcinoma"}
    SLC2A1 -->|"associated with"| Carcinoma
    Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
    SLC2A1 -->|"inhibits"| Oxidative_Phosphorylation
    Akt(["Akt"])
    SLC2A1 -->|"interacts with"| Akt
    Epigenetic(["Epigenetic"])
    SLC2A1 -->|"associated with"| Epigenetic
    CANCER["CANCER"]
    CANCER -->|"inhibits"| SLC2A1
    RB1["RB1"]
    RB1 -->|"inhibits"| SLC2A1
    PIK3CA["PIK3CA"]
    PIK3CA -->|"interacts with"| SLC2A1
    MMP9["MMP9"]
    MMP9 -->|"interacts with"| SLC2A1
    PPARA["PPARA"]
    PPARA -->|"interacts with"| SLC2A1
    IGF1R["IGF1R"]
    IGF1R -->|"interacts with"| SLC2A1
    RELA["RELA"]
    RELA -->|"interacts with"| SLC2A1
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| SLC2A1
    INSR["INSR"]
    INSR -->|"interacts with"| SLC2A1
    TTR["TTR"]
    TTR -->|"interacts with"| SLC2A1
    PPARG["PPARG"]
    PPARG -->|"interacts with"| SLC2A1
    ESR1["ESR1"]
    ESR1 -->|"interacts with"| SLC2A1
    style SLC2A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0