Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TPX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TPX2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | TPX2 |
| Function | TPX2 (Targeting Protein for Xklp2) is a microtubule-associated protein that functions as a key regulator of microtubule nucleation during mitosis[@wittmann2000]. |
| Primary Expression | lung, breast, ovarian, pancreatic cancers[@gingold2014] - Prognostic marker: High expression correlates with poor prognosis[@suitters2007] - The |
| Pathways | Autophagy, Angiogenesis |
| UniProt ID | Q9ULW0 |
| Ensembl ID | ENSG00000178999 |
| GeneCards | TPX2 |
| Human Protein Atlas | TPX2 |
| Microtubule nucleation | TPX2 triggers microtubule formation from γ-TuRC complexes[@tulu2006] |
| Spindle assembly | Recruits and activates Aurora A kinase at spindle poles[@tsai2003] |
| Kinesin-5 inhibition | Controls spindle dynamics by modulating Eg5/kinesin-5 activity[@mayer1999] |
| Chromosome alignment | Facilitates proper kinetochore-microtubule attachments[@obrien2008] |
| Multiple cancers | TPX2 overexpressed in lung, breast, ovarian, pancreatic cancers[@gingold2014] |
| Prognostic marker | High expression correlates with poor prognosis[@suitters2007] |
| Therapeutic target | TPX2 as biomarker and potential target[@tan2015] |
| Associated Diseases | Als, Ataxia, Infection |
| Interactions | LC3, AURKA, AKT, VEGFA, NFATC2, CTSB |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TPX2["TPX2 Gene"]
%% Key activated targets
AURKA["AURKA Kinase"]
AKT["AKT Pathway"]
LC3["LC3 Autophagy Marker"]
VEGFA["VEGFA Growth Factor"]
%% Pathways
Autophagy["Autophagy Pathway"]
Angiogenesis["Angiogenesis"]
%% DNA damage response
ATM["ATM Kinase"]
ATR["ATR Kinase"]
CHEK1["CHEK1"]
%% Cellular structures
MICROTUBULES["Microtubules"]
SYN1["Synapsin 1"]
%% Diseases
ALS["Amyotrophic Lateral Sclerosis"]
Ataxia["Ataxia"]
Cancer["Cancer"]
%% Connections
TPX2 -->|"activates"| AURKA
TPX2 -->|"activates"| AKT
TPX2 -->|"activates"| LC3
TPX2 -->|"activates"| VEGFA
TPX2 -->|"activates"| Autophagy
TPX2 -->|"activates"| Angiogenesis
TPX2 -->|"inhibits"| ATM
TPX2 -->|"inhibits"| ATR
TPX2 -.->|"associated with"| CHEK1
TPX2 -.->|"associated with"| MICROTUBULES
TPX2 -.->|"associated with"| SYN1
TPX2 -->|"contributes to"| ALS
TPX2 -->|"associated with"| Ataxia
TPX2 -->|"promotes"| Cancer
AURKA -->|"regulates"| MICROTUBULES
VEGFA -->|"drives"| Angiogenesis
LC3 -->|"mediates"| Autophagy
style TPX2 fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#333
style AURKA fill:#4a1a6b,stroke:#333
style AKT fill:#4a1a6b,stroke:#333
style LC3 fill:#4a1a6b,stroke:#333
style VEGFA fill:#4a1a6b,stroke:#333
style ATM fill:#4a1a6b,stroke:#333
style ATR fill:#4a1a6b,stroke:#333
style CHEK1 fill:#4a1a6b,stroke:#333
style MICROTUBULES fill:#4a1a6b,stroke:#333
style SYN1 fill:#4a1a6b,stroke:#333
style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0
style Cancer fill:#7d4200,stroke:#333
style Angiogenesis fill:#7d4200,stroke:#333| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Infection | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| LC3 | activates | gene | 0.60 |
| AURKA | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| VEGFA | activates | gene | 0.60 |
| NFATC2 | activates | gene | 0.60 |
| CTSB | activates | gene | 0.60 |
| ATM | inhibits | gene | 0.60 |
| MDC1 | associated_with | gene | 0.60 |
| ATR | inhibits | gene | 0.60 |
| MRE11 | associated_with | gene | 0.60 |
| SYN1 | associated_with | gene | 0.60 |
| CHEK1 | associated_with | gene | 0.60 |
| CHMP6 | inhibits | gene | 0.60 |
| EIF4EBP1 | associated_with | gene | 0.60 |
| SLC2A1 | associated_with | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Angiogenesis | activates | pathway | 0.60 |
| AND | inhibits | gene | 0.60 |
| MICROTUBULES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| ENDOSOME | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||