concept

MEMORY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEMORY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

30Hypotheses

4Analyses

1Outgoing

50Incoming

10Experiments

4Debates

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💡 Concept Info

Name	MEMORY
Key Genes/Proteins	BDNF, CYP46A1, GD3 synthase, IGF2, M1_RECEPTOR
Related Diseases	EXERCISE, LTP

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Reuniens Thalamic Nucleus in Memory

cell · 1472 words

→

Pathway Diagram

graph TD
    MEMORY["MEMORY"]
    IGF2["IGF2"] -->|"modulates"| MEMORY
    Caffeine["Caffeine"] -->|"modulates"| MEMORY
    GSK3__["GSK3-beta"] -->|"regulates"| MEMORY
    EXERCISE["EXERCISE"] -->|"activates"| MEMORY
    Alzheimer_s_disease["Alzheimer's disease"] -->|"causes"| MEMORY
    Hippocampus["Hippocampus"] -->|"activates"| MEMORY
    BDNF["BDNF"] -->|"regulates"| MEMORY

Outgoing (1)

Target	Relation	Type	Str
Synaptic Autophagy	associated_with	process	0.85

Incoming (54)

Source	Relation	Type	Str
hippocampus	involved_in	brain_region	0.95
IGF2	regulates	gene	0.95
IGF2	associated_with	protein	0.95
IGF2	upregulates	protein	0.90
Glp1 Receptor Agonists	associated_with	drug	0.90
Mch Neurons	mediates	cell_type	0.90
36257934	represent a fundamental neurophysiological unit supporting	paper	0.90
18568035	disrupt	paper	0.90
FB23	associated_with	drug	0.90
BDNF	promotes	gene	0.90
ST8SIA1	regulates	gene	0.90
27025652	impair	paper	0.90
PSN1	contributes_to	protein	0.85
PKN1-N207	associated_with	protein	0.85
Hdac3 Inhibition	associated_with	mechanism	0.85
Brain Amyloid-Beta Reduction	associated_with	process	0.85
Caffeine	modulates	compound	0.85
Hcrtr2	regulates	protein	0.85
IGF2	enhances	gene	0.80
CLU	modulates	protein	0.80
Oveporexton	associated_with	drug	0.80
GD3 synthase	improves	gene	0.80
Gamma-Secretase Complex	involved_in	enzyme	0.80
BDNF	associated_with	protein	0.80
Neurodegenerative Diseases	causes	disease	0.80
GSK3-β	regulates	enzyme	0.80
Unfolded Protein Response	associated_with	pathway	0.75
Rehmannia glutinosa Libosch	associated_with	compound	0.75
Ginsenoside Rg1	regulates	compound	0.75
SNCA	involved_in	protein	0.75
EXERCISE	activates	phenotype	0.72
Gastrodin	promotes	compound	0.70
BDNF	regulates	protein	0.70
40 Hz tACS	enhances	drug	0.70
Irisin	improves	protein	0.70
BDNF	enhances	gene	0.70
Rapamycin	improves	drug	0.70
irisin	associated_with	protein	0.70
Alzheimer's disease	causes	disease	0.70
JQ1	improves	drug	0.70
Gastrodin	protects_against	compound	0.70
PTN	activates	protein	0.70
Hippocampus	activates	entity	0.70
BDNF	activates	protein	0.68
LTP	regulates	phenotype	0.68
M1_RECEPTOR	regulates	protein	0.64
PVALB	involved_in	protein	0.60
HDAC3	regulates	protein	0.60
39559873	showed positive impact on	paper	0.60
15483599	could depend on	paper	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Alpha-gamma cross-frequency coupling enhancement to restore	0.775	alzheimers	Circuit-level neural dynamics in neurode
Epigenetic Memory Erasure via TET2 Activation	0.741	neurodegeneration	Astrocyte reactivity subtypes in neurode
PGE2–EP2–cAMP–PKA Axis Displaces Pathological Microglial Mem	0.681	neuroinflammation	What specific astrocyte-derived factors
Astrocyte-Mediated Microglial Memory Erasure	0.677	-	Neuroinflammation and microglial priming
Epigenetic Reprogramming of Microglial Memory	0.647	alzheimers	Neuroinflammation and microglial priming

Epigenetic Memory Reprogramming for Alzheimer's Disease	0.611	neurodegeneration	CRISPR-based therapeutic approaches for
Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Traine	0.588	neuroinflammation	What specific astrocyte-derived factors
Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat	0.544	neurodegeneration	CRISPR-based therapeutic approaches for
Astrocyte Metabolic Memory Reprogramming	0.541	neurodegeneration	How do astrocyte-neuron metabolic intera
Sleep-Stage TFUS to Restore SWR-Gamma Coupling and Memory Co	0.525	alzheimers	Closed-loop transcranial focused ultraso
ApoE4-Mediated Failure of Cholesterol Efflux as Memory Maint	0.515	neuroinflammation	What specific astrocyte-derived factors
ADCY8-PKA-CREB Spatial Memory Enhancement	0.455	memory-and-navigation	How does ADCY8 mechanistically regulate
ADCY8-cAMP Memory Consolidation Enhancer	0.455	memory-and-navigation	How does ADCY8 mechanistically regulate
Circadian-Spatial Memory Coupling Therapy	0.455	memory-and-navigation	How does ADCY8 mechanistically regulate
Epigenetic ADCY8 Memory Programming	0.455	memory-and-navigation	How does ADCY8 mechanistically regulate
Magnetic Field Sensing-Memory Interface Therapy	0.455	memory-and-navigation	How does ADCY8 mechanistically regulate
Metabolic Memory Support Therapy	0.455	spatial-memory	What neural circuits encode and maintain
Stress-Resilient Memory Formation Protocol	0.455	spatial-memory	What neural circuits encode and maintain
Circadian-Spatial Memory Coupling for Navigation Disorders	0.455	spatial-memory	What neural circuits encode and maintain
Social Memory Network Enhancement Therapy	0.455	spatial-memory	What neural circuits encode and maintain
Epigenetic Memory Engram Therapy for Alzheimer's Disease	0.455	spatial-memory	What neural circuits encode and maintain
Developmental Critical Period Extension for Memory Recovery	0.455	spatial-memory	What neural circuits encode and maintain
Magnetic Field Stimulation for Memory Consolidation	0.455	spatial-memory	What neural circuits encode and maintain
HBOT at 2.0 ATA for 60 min, 5x/week for 6 weeks enhances hip	0.450	neurodegeneration	What are the optimal oxygen pressure, du
STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine	0.347	immunomics	Systemic immune profiling in neurodegene
Epigenetic Memory Erasure in Aged Microglia	0.000	-	Neuroinflammation and microglial priming
Metabolic Memory Reprogramming via Molecular Switches	0.000	-	Astrocyte reactivity subtypes in neurode
Stress-Responsive Epigenetic Memory (SREM)	0.000	-	Do different priming stimuli require dis
The "Trans-Cellular Prion-Like Propagation of Transcriptiona	0.000	alzheimers	SEA-AD Gene Expression Profiling — Allen
Innate Immunity Memory Erasure Protocol	0.000	-	Epigenetic reprogramming in aging neuron

Mentioning Analyses (4)

Scientific analyses that reference this entity

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.670

What are the specific circulating factors in exercise-conditioned plasma that me

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.679

Investigate mechanisms of epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.770

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study	validation	Alzheimer's disease	0.900	0.00	young APPswe/PSEN1 double-tran	proposed	N/A
Acteoside treatment in LPS-induced SALI mouse model	validation	sepsis-associated acute lung i	0.900	0.00	LPS-induced SALI mouse model	proposed	N/A
Tet2 expression analysis in aged 2×Tg-AD mouse brains	exploratory	Alzheimer's disease	0.850	0.00	APPswe/PSEN1 double-transgenic	proposed	N/A
Single-cell RNA sequencing of microglial states in AD hippocampus	exploratory	Alzheimer's disease	0.850	0.00	AD mouse hippocampus	proposed	N/A
Nrf2 inhibitor ML385 mechanism validation experiment	exploratory	sepsis-associated acute lung i	0.850	0.00	RAW264.7 cells and/or mouse mo	proposed	N/A
Acteoside effects on RAW264.7 macrophage cells	exploratory	sepsis-associated acute lung i	0.850	0.00	RAW264.7 cells	proposed	N/A
Morphological characterization of microglial states in human brain	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Proposed experiment from debate on Epigenetic clocks and biological ag	falsification	Neurodegeneration	0.400	0.50	mouse	completed	$450,000
CRISPR Gene Correction Approaches for CBS/PSP	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507]	Koh Y, Tengesdal IW, Jaiswal S	Annu Rev Pathol	2026	1
Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression a [PMID:40752494]	Liu Z, Zhang S, James BT, Galani K, Mang	Cell	2025	1
Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical [PMID:38678292]	Oosthoek M, Vermunt L, de Wilde A, Bonge	Alzheimer's research & therapy	2024	1
TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094]	Jain N, Zhao Z, Feucht J, Koche R, Iyer	Nature	2023	1
Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826]	Singh I, Singh A	Curr Oncol Rep	2023	1
Detailed stratified GWAS analysis for severe COVID-19 in four European populatio [PMID:35848942]	Degenhardt F, Ellinghaus D, Juzenas S, L	Human molecular genetics	2022	1
The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059]	Cong B, Zhang Q, Cao X	Protein Cell	2021	1
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Hom [PMID:29548672]	Datta M, Staszewski O, Raschi E, Frosch	Immunity	2018	1
Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines [PMID:26746105]	Herbert J, Lucassen PJ	Frontiers in neuroendocrinolog	2016	1
Global epigenomic reconfiguration during mammalian brain development. [PMID:23828890]	Lister R, Mukamel EA, Nery JR, Urich M,	Science	2013	1
TET1 deficiency amplifies macrophage inflammatory signaling associated with Croh [PMID:41896302]	["Perez R", "Paul R", "Kumar P", "Tutkun	Inflammation research : offici	2026	0
Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042]	["Lyu G", "Li D"]	CNS & neurological disorders d	2026	0
Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pa [PMID:41811389]	Liu K, Hong Y, Gao Q, Huang J, Liu L, Li	Cellular and molecular life sc	2026	0
Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms. [PMID:41899316]	["Sinnadurai S", "Honigberg M", "Meijers	Journal of clinical medicine	2026	0
Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects. [PMID:41926089]	Park CS, Ryu G, Ahn HJ, Sun C, Lee SP, K	JAMA oncology	2026	0
Chimeric antigen receptor T-cell therapies related to immune effector cell-assoc [PMID:41914034]	Zhang Y, Yang J, Xin H, Ai K, Yang M, Li	Chinese medical journal	2026	0
Targeting synaptic plasticity and acetylcholine dysregulation in the medial pref [PMID:41014339]	Shi J, Chen M, Zhang Y, Fan X, Wang L et	Psychopharmacology (Berl)	2026	0
Obstructive sleep apnea, biomarker profiles, and clinical progression in Parkins [PMID:41499940]	Zhu S, An D, Liu X	Sleep Med	2026	0
Systemic inflammation and its associations in acute moderate-severe Traumatic Br [PMID:41623670]	Li LM, Kodosaki E, Xu CJY, Heslegrave A,	Brain Behav Immun Health	2026	0
Time-dependent neurovascular unit dysfunction in ischemic stroke: mechanisms of [PMID:41642667]	Lahariya R, Sinha M, Kumari B, Subramani	Int J Neurosci	2026	0

Debates (4)

Multi-agent debates referencing this entity

Structured research brief for hypothesis h-var-b7e4505525: Closed-loop transcran

closed · Rounds: 4 · Score: 0.63 · 2026-04-28

Investigate mechanisms of epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.79 · 2026-04-22

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

The study demonstrates that exercise-conditioned plasma transfers cognitive bene

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning MEMORY in their description or question text

Epigenetic Memory Reprogramming for Alzheimer's Disease

Score: 0.611 · neurodegeneration · 2026-04-02

## Mechanistic Overview Epigenetic Memory Reprogramming for Alzheimer's Disease starts from the claim that modulating BD

Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Trained Microglial NF-κB M

Score: 0.588 · neuroinflammation · 2026-04-26

AEVs containing miR-146a-5p are taken up by microglia and suppress IRAK1/TRAF6, disrupting sustained NF-κB activation th

Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromatin Remodeling

Score: 0.544 · neurodegeneration · 2026-04-04

## Mechanistic Overview Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromatin Remodeling starts from the claim

Astrocyte Metabolic Memory Reprogramming

Score: 0.541 · neurodegeneration · 2026-04-12

## Mechanistic Overview Astrocyte Metabolic Memory Reprogramming starts from the claim that modulating SIRT1 within the

Sleep-Stage TFUS to Restore SWR-Gamma Coupling and Memory Consolidation

Score: 0.525 · alzheimers · 2026-04-28

H4 represents the strongest systems-neuroscience endpoint from the debate, focusing on restoring hippocampal sleep physi

ApoE4-Mediated Failure of Cholesterol Efflux as Memory Maintenance Mechanism

Score: 0.515 · neuroinflammation · 2026-04-26

Incomplete hypothesis (truncated). ApoE4 isoform from astrocytes fails to mediate proper cholesterol efflux from microgl