Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MEMORY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MEMORY |
| Summary | Page for Amygdala in Fear Memory |
| Key Genes/Proteins | BDNF, GD3 synthase, IGF2, M1_RECEPTOR, CYP46A1 |
| Related Diseases | EXERCISE, LTP |
| Linked Hypotheses | 8 hypotheses |
Knowledge base pages for this entity
graph TD
MEMORY["MEMORY"]
IGF2["IGF2"] -->|"modulates"| MEMORY
Caffeine["Caffeine"] -->|"modulates"| MEMORY
GSK3__["GSK3-beta"] -->|"regulates"| MEMORY
EXERCISE["EXERCISE"] -->|"activates"| MEMORY
Alzheimer_s_disease["Alzheimer's disease"] -->|"causes"| MEMORY
Hippocampus["Hippocampus"] -->|"activates"| MEMORY
BDNF["BDNF"] -->|"regulates"| MEMORY| Target | Relation | Type | Str |
|---|---|---|---|
| Synaptic Autophagy | associated_with | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | promotes | gene | 0.90 |
| GD3 synthase | improves | gene | 0.80 |
| IGF2 | enhances | gene | 0.80 |
| EXERCISE | activates | phenotype | 0.72 |
| BDNF | enhances | gene | 0.70 |
| BDNF | activates | protein | 0.68 |
| LTP | regulates | phenotype | 0.68 |
| M1_RECEPTOR | regulates | protein | 0.64 |
| CYP46A1 | protects_against | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Alpha-gamma cross-frequency coupling enhancement to restore | 0.621 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat | 0.517 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Epigenetic Memory Erasure via TET2 Activation | 0.515 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| Epigenetic Reprogramming of Microglial Memory | 0.508 | Alzheimer's disease | Neuroinflammation and microglial priming |
| Astrocyte Metabolic Memory Reprogramming | 0.478 | neurodegeneration | How do astrocyte-neuron metabolic intera |
| Epigenetic Memory Reprogramming for Alzheimer's Disease | 0.467 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Astrocyte-Mediated Microglial Memory Erasure | 0.462 | - | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
behavioral neuroscience | 2026-04-11 | 0 hypotheses
neuroscience | 2026-04-11 | 0 hypotheses
spatial memory | 2026-04-08 | 0 hypotheses
memory and navigation | 2026-04-08 | 0 hypotheses
neuroinflammation | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507] | Koh Y, Tengesdal IW, Jaiswal S | Annu Rev Pathol | 2026 | 1 |
| Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression a [PMID:40752494] | Liu Z, Zhang S, James BT, Galani K, Mang | Cell | 2025 | 1 |
| Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical [PMID:38678292] | Oosthoek M, Vermunt L, de Wilde A, Bonge | Alzheimer's research & therapy | 2024 | 1 |
| TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094] | Jain N, Zhao Z, Feucht J, Koche R, Iyer | Nature | 2023 | 1 |
| Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826] | Singh I, Singh A | Curr Oncol Rep | 2023 | 1 |
| Detailed stratified GWAS analysis for severe COVID-19 in four European populatio [PMID:35848942] | Degenhardt F, Ellinghaus D, Juzenas S, L | Human molecular genetics | 2022 | 1 |
| The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059] | Cong B, Zhang Q, Cao X | Protein Cell | 2021 | 1 |
| Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Hom [PMID:29548672] | Datta M, Staszewski O, Raschi E, Frosch | Immunity | 2018 | 1 |
| Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines [PMID:26746105] | Herbert J, Lucassen PJ | Frontiers in neuroendocrinolog | 2016 | 1 |
| Global epigenomic reconfiguration during mammalian brain development. [PMID:23828890] | Lister R, Mukamel EA, Nery JR, Urich M, | Science | 2013 | 1 |
| Targeting synaptic plasticity and acetylcholine dysregulation in the medial pref [PMID:41014339] | Shi J, Chen M, Zhang Y, Fan X, Wang L et | Psychopharmacology (Berl) | 2026 | 0 |
| Obstructive sleep apnea, biomarker profiles, and clinical progression in Parkins [PMID:41499940] | Zhu S, An D, Liu X | Sleep Med | 2026 | 0 |
| Systemic inflammation and its associations in acute moderate-severe Traumatic Br [PMID:41623670] | Li LM, Kodosaki E, Xu CJY, Heslegrave A, | Brain Behav Immun Health | 2026 | 0 |
| Time-dependent neurovascular unit dysfunction in ischemic stroke: mechanisms of [PMID:41642667] | Lahariya R, Sinha M, Kumari B, Subramani | Int J Neurosci | 2026 | 0 |
| Integrative Proteomics Reveal Neuroimmune and Dopaminergic Alterations Across th [PMID:41677653] | Majumdar S, Prajapati SK, Dande A, Yata | Cells | 2026 | 0 |
| Astroglial and Neuronal Injury Markers (GFAP, UCHL-1, NfL, Tau, S100B) as Diagno [PMID:41828591] | Ogłodek EA, Bar M | Int J Mol Sci | 2026 | 0 |
| Interconnected roles of astrocytes and the blood-brain barrier in Parkinson's di [PMID:41868432] | Stoll AC, Harms AS | Front Aging Neurosci | 2026 | 0 |
| TET1 deficiency amplifies macrophage inflammatory signaling associated with Croh [PMID:41896302] | ["Perez R", "Paul R", "Kumar P", "Tutkun | Inflammation research : offici | 2026 | 0 |
| Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pa [PMID:41811389] | Liu K, Hong Y, Gao Q, Huang J, Liu L, Li | Cellular and molecular life sc | 2026 | 0 |
| Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms. [PMID:41899316] | ["Sinnadurai S", "Honigberg M", "Meijers | Journal of clinical medicine | 2026 | 0 |