concept

PTN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections

1Hypotheses

1Analyses

50Outgoing

39Incoming

Summary

PTN is a concept in neurodegeneration research. Key relationships include: expressed in, interacts with, implicated in. Associated with AD, ALI, ALS. Connected to 74 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PTN
Key Genes/Proteins	PTPRZ1
Related Diseases	Alzheimer'S Disease, cognitive impairment, Alzheimer, ALS, Cancer
Linked Hypotheses	1 hypotheses

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PTN["<b>PTN</b>"]
    PTN -->|"interacts"| PTPRZ1["PTPRZ1"]
    PTN -->|"activates"| adult_hippocampal_neurogenesis["adult hippocampal neurogenesis"]
    PTN -.protects against.-> cognitive_impairment["cognitive impairment"]
    PTN -.protects against.-> memory_deficits["memory deficits"]
    PTN -->|"activates"| memory["memory"]
    PTN -.biomarker for.-> Alzheimer["Alzheimer"]
    PTN -->|"expressed in"| ALS["ALS"]
    PTN -.biomarker for.-> Amyloid["Amyloid"]
    PTN -->|"interacts"| AMYLOID["AMYLOID"]
    PTN -->|"expressed in"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    PTN -->|"expressed in"| JUN["JUN"]
    aging["aging"] -->|"regulates"| PTN
    AMYLOID -.biomarker for.-> PTN
    ALZHEIMER_S_DISEASE -.biomarker for.-> PTN
    ALZHEIMER["ALZHEIMER"] -.biomarker for.-> PTN
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| PTN
    NTN1["NTN1"] -->|"interacts"| PTN
    TARDBP["TARDBP"] -->|"interacts"| PTN
    SNRNP70["SNRNP70"] -->|"interacts"| PTN
    AND["AND"] -->|"interacts"| PTN

Outgoing (80)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.85
ALZHEIMER'S DISEASE	associated_with	entity	0.80
PTPRZ1	interacts_with	protein	0.70
adult hippocampal neurogenesis	activates	process	0.70
cognitive impairment	protects_against	disease	0.70
memory deficits	protects_against	process	0.70
memory	activates	process	0.70
Alzheimer	biomarker_for	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Depression	activates	disease	0.65
Ms	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Amyloid	biomarker_for	pathway	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
DNA	interacts_with	gene	0.60
NTN1	interacts_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
SNRNP70	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
NTN3	interacts_with	gene	0.60
Protein Aggregation	expressed_in	pathway	0.60
Amyloid	interacts_with	pathway	0.60
Endocytosis	expressed_in	pathway	0.60
Exocytosis	expressed_in	pathway	0.60
Complement	expressed_in	pathway	0.60
GPNMB	associated_with	gene	0.60
AMYLOID	biomarker_for	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
CD4	expressed_in	gene	0.60
Microrna	expressed_in	pathway	0.60
ASTROCYTES	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60
DEPRESSION	activates	gene	0.60
NEURON	inhibits	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
VGF	associated_with	gene	0.60
AND	inhibits	gene	0.60
PTPRZ1	inhibits	gene	0.60

Incoming (39)

Source	Relation	Type	Str
aging	regulates	process	0.70
GPNMB	associated_with	gene	0.60
AMYLOID	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
VGF	associated_with	gene	0.60
NTN1	associated_with	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NPTX2	associated_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
NTN1	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
SNRNP70	interacts_with	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
ROBO1	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
PTPRZ1	inhibits	gene	0.60
AND	associated_with	gene	0.60
DNA	interacts_with	gene	0.60
RNA	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
AND	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
NTN3	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
GPNMB	interacts_with	gene	0.60
NPTX2	interacts_with	gene	0.60
AKT	activates	gene	0.60
CSF1	activates	gene	0.60
CSF1R	activates	gene	0.60
FGF1	activates	gene	0.60
FGFR2	activates	gene	0.60
APP	expressed_in	gene	0.60
PS1	expressed_in	gene	0.60
JNK	activates	gene	0.60
MAPK	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2 Agonism to Redirect Microglia from Synaptic Pruning to	0.521	neurodegeneration	How do ALS-associated OPTN mutations mec

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PTN