concept

MYELOID CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYELOID CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

1Analyses

20Outgoing

29Incoming

0Experiments

1Debates

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💡 Concept Info

Name	MYELOID CELLS
Key Genes/Proteins	APOE, GFAP, HDAC3, MAPK
Related Diseases	ALZHEIMER'S DISEASE, CANCER, FIBROSIS, OSTEOPOROSIS, PHAGOCYTOSIS
Related Pathways	NLRP3 INFLAMMASOME

Pathway Diagram

graph TD
    MYELOID_CELLS["MYELOID CELLS"]
    MYELOID_CELLS -->|"involved_in"| Phagocytosis["Phagocytosis"]
    MYELOID_CELLS -->|"mediates"| Bone_Resorption["Bone Resorption"]
    MYELOID_CELLS -->|"involved_in"| Central_Nervous_System["Central Nervous System"]
    MYELOID_CELLS -->|"promotes"| neuronal_debris_clearance["neuronal debris clearance"]
    TET2["TET2"] -->|"expressed in"| MYELOID_CELLS
    Mitochondria["Mitochondria"] -->|"interacts"| MYELOID_CELLS
    Osteolineage_Cells["Osteolineage Cells"] -->|"interacts"| MYELOID_CELLS
    TREM2["TREM2"] -->|"expressed in"| MYELOID_CELLS
    Regulatory_T_cells["Regulatory T cells"] -->|"inhibits"| MYELOID_CELLS
    Inflammatory_Response["Inflammatory Response"] -->|"involved_in"| MYELOID_CELLS

Outgoing (20)

Target	Relation	Type	Str
Phagocytosis	involved_in	process	0.93
Inflammation	involved_in	process	0.92
Bone Resorption	mediates	process	0.90
Tumor Microenvironment	involved_in	process	0.90
Phagocytosis	mediates	process	0.90
Atherosclerosis	promotes	disease	0.88
Central Nervous System	involved_in	process	0.85
neuronal debris clearance	promotes	process	0.80
Central Nervous System	expressed_in	cell_type	0.80
Skeletal Homeostasis	associated_with	process	0.80
NMJ denervation	associated_with	phenotype	0.70
OSTEOPOROSIS	activates	disease	0.65
MACROPHAGES	interacts_with	cell_type	0.65
STEM CELLS	activates	cell_type	0.65
T CELLS	activates	cell_type	0.65
T CELLS	produces	cell_type	0.65
FIBROSIS	causes	disease	0.65
FIBROSIS	activates	disease	0.65
APOE	activates	gene	0.65
OSTEOPOROSIS	implicated_in	disease	0.55

Incoming (29)

Source	Relation	Type	Str
Mitochondria	interacts_with	cell_type	0.95
Mitochondria	modulates	cell_type	0.95
TET2	expressed_in	gene	0.95
osteolineage cells	associated_with	cell_type	0.90
TREM2	expressed_in	gene	0.90
Osteolineage Cells	interacts_with	cell_type	0.90
TREM2	expressed_in	protein	0.85
C1Q	suppresses	gene	0.80
Regulatory T cells	inhibits	cell_type	0.80
Inflammatory Response	involved_in	process	0.80
HDAC3	activates	gene	0.70
TAU	causes	protein	0.70
GFAP	causes	gene	0.70
SYK	phosphorylates	gene	0.65
SYK	causes	gene	0.65
PHAGOCYTOSIS	causes	phenotype	0.65
PHAGOCYTOSIS	protects_against	phenotype	0.65
MACROPHAGES	causes	cell_type	0.65
NLRP3 INFLAMMASOME	interacts_with	pathway	0.65
ALZHEIMER'S DISEASE	causes	disease	0.65
NEURONS	causes	cell_type	0.65
CANCER	causes	disease	0.65
APOE	causes	gene	0.65
TREM2	causes	gene	0.65
MAPK	activates	gene	0.65
MICROGLIA	causes	cell_type	0.65
31434879	expressed in	paper	0.60
NEUROFILAMENT LIGHT	associated_with	biomarker	0.50
NLRP3 INFLAMMASOME	associated_with	pathway	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell-Autonomous vs Non-Cell-Autonomous Mechanisms of Mutant FUS Neuromuscular De

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the relative contributions of cell-autonomous motor neuron mechanisms v

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

Related Research

Hypotheses and analyses mentioning MYELOID CELLS in their description or question text

No additional research found