concept

STEM CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STEM CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

876Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	STEM CELLS
Key Genes/Proteins	TDP-43, TAU, SQSTM1, BECN1, MTOR
Related Diseases	CANCER, ALS, PARKINSON'S DISEASE, FRONTOTEMPORAL DEMENTIA

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Corticobasal Syndrome (CBS)

disease · 11374 words

→

Pathway Diagram

graph TD
    STEM_CELLS["STEM CELLS"]
    STEM_CELLS -->|"activates"| TDP_43["TDP-43"]
    STEM_CELLS -->|"activates"| TAU["TAU"]
    STEM_CELLS -->|"activates"| TFEB["TFEB"]
    STEM_CELLS -->|"treats"| Parkinson_s_Disease["Parkinson's Disease"]
    STEM_CELLS -->|"activates"| STING["STING"]
    STEM_CELLS -->|"activates"| UBIQUITIN["UBIQUITIN"]
    STEM_CELLS -->|"activates"| UNFOLDED_PROTEIN_RESPONSE["UNFOLDED PROTEIN RESPONSE"]
    STEM_CELLS -->|"activates"| ULK1["ULK1"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| STEM_CELLS
    CANCER["CANCER"] -->|"activates"| STEM_CELLS
    RAPAMYCIN["RAPAMYCIN"] -->|"activates"| STEM_CELLS
    SQSTM1["SQSTM1"] -->|"activates"| STEM_CELLS
    BECN1["BECN1"] -->|"activates"| STEM_CELLS
    MTOR["MTOR"] -->|"activates"| STEM_CELLS
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"activates"| STEM_CELLS
    IPSC["IPSC"] -->|"activates"| STEM_CELLS

Outgoing (82)

Target	Relation	Type	Str
TDP-43	activates	gene	0.95
TAU	activates	protein	0.95
TFEB	activates	gene	0.80
neurodegenerative disorders	treats	disease	0.80
PROTECTIVE EFFECTS	exerts	phenotype	0.80
ASTROCYTES	interacts_with	cell_type	0.70
MYC	activates	gene	0.70
ASTROGLIOSIS	causes	phenotype	0.65
ENDOPLASMIC RETICULUM STRESS	treats	phenotype	0.65
CANCER	exacerbates	disease	0.65
EGF	activates	gene	0.65
ABL1	targets	gene	0.65
IMATINIB	interacts_with	drug	0.65
IMATINIB	inhibits	drug	0.65
NEURONS	protects_against	cell_type	0.65
NEURONS	expressed_in	cell_type	0.55
STING	activates	gene	0.50
UBIQUITIN	activates	gene	0.50
UNFOLDED PROTEIN RESPONSE	activates	process	0.50
ULK1	activates	gene	0.50
ENDOPLASMIC RETICULUM	inhibits	concept	0.50
ENDOPLASMIC RETICULUM	regulates	concept	0.50
RAPAMYCIN	activates	concept	0.50
PEROXISOME	activates	concept	0.50
CENTRAL NERVOUS SYSTEM	regulates	concept	0.50
ORGANOIDS	associated_with	concept	0.50
ORGANOIDS	activates	concept	0.50
EXTRACELLULAR VESICLES	associated_with	concept	0.50
IPSC	activates	concept	0.50
IPSC	associated_with	concept	0.50
DENDRITE	activates	concept	0.50
EXTRACELLULAR VESICLES	activates	concept	0.50
MTOR SIGNALING	activates	concept	0.50
MTOR SIGNALING	inhibits	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
EXTRACELLULAR VESICLES	interacts_with	concept	0.50
B CELLS	activates	concept	0.50
NEUTROPHILS	activates	concept	0.50
DENDRITIC CELLS	activates	concept	0.50
FIBROBLASTS	activates	concept	0.50
FIBROBLASTS	interacts_with	concept	0.50
DOPAMINERGIC NEURONS	associated_with	concept	0.50
DOPAMINERGIC NEURONS	activates	concept	0.50
CURCUMIN	interacts_with	concept	0.50
CURCUMIN	activates	concept	0.50
IMATINIB	associated_with	drug	0.50
RAPAMYCIN	associated_with	drug	0.45
SORAFENIB	associated_with	drug	0.45
MELATONIN	associated_with	drug	0.45
CURCUMIN	associated_with	drug	0.45

Incoming (794)

Source	Relation	Type	Str
AUTOPHAGY	activates	process	0.95
CANCER	activates	disease	0.95
RAPAMYCIN	activates	drug	0.95
SQSTM1	activates	gene	0.95
BECN1	activates	gene	0.95
MTOR	activates	gene	0.95
MOTOR NEURONS	activates	cell_type	0.95
IPSC	activates	cell_type	0.95
ALS	activates	disease	0.95
PARKINSON'S DISEASE	activates	disease	0.95
FIBROBLASTS	activates	cell_type	0.95
ASTROCYTES	activates	cell_type	0.95
FRONTOTEMPORAL DEMENTIA	activates	disease	0.95
NEURON	activates	cell_type	0.95
CORTEX	activates	brain_region	0.95
NEURODEGENERATION	activates	process	0.95
ORGANOIDS	activates	cell_type	0.95
MICROGLIA	activates	cell_type	0.95
CANCER	associated_with	disease	0.80
STAT3	activates	gene	0.80
LC3	activates	gene	0.80
NEURON	regulates	cell_type	0.80
AGING	activates	process	0.80
NEURON	interacts_with	cell_type	0.80
MACROPHAGES	activates	cell_type	0.80
TET2	causes	gene	0.70
TH	activates	gene	0.70
CX3CR1	produces	gene	0.70
CX3CR1	activates	gene	0.70
LRP1	activates	gene	0.70
CANCER	therapeutic_target	disease	0.65
ROS	activates	protein	0.65
DENDRITIC CELLS	activates	cell_type	0.65
P62	activates	gene	0.65
CANCER	repairs	disease	0.65
AGING	associated_with	process	0.65
CANCER	regulates	disease	0.65
AGING	interacts_with	process	0.65
DOPAMINERGIC NEURONS	activates	cell_type	0.65
MTOR SIGNALING	regulates	pathway	0.65
NEURONS	produces	cell_type	0.65
LYSOSOMAL DYSFUNCTION	treats	phenotype	0.65
AGING	inhibits	phenotype	0.65
MYELOID CELLS	activates	cell_type	0.65
TH	stabilizes	gene	0.60
PARKINSON'S DISEASE	converts	disease	0.60
WNT SIGNALING	implicated_in	pathway	0.60
APOPTOSIS	implicated_in	process	0.50
CANCER	implicated_in	disease	0.50
COLORECTAL CANCER	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STEM CELLS

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

Parthanatos in Neurodegeneration

Alpha-Synuclein Pathology

nhp-validation-animal-model

nimodipine-als

Therapeutics

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings

Multiple System Atrophy

Alzheimer's Disease

Frontotemporal Dementia (FTD)

PD Cure Roadmap

Microglial Cells — Cell Type Hierarchy