concept

T CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about T CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

853Connections

0Hypotheses

5Analyses

50Outgoing

50Incoming

Summary

T CELLS is a concept in neurodegeneration research. Key relationships include: co discussed, activates, inhibits. Associated with CANCER, ISCHEMIA, LYMPHOMA. Connected to 126 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	T CELLS
Key Genes/Proteins	CD4, CD8
Related Diseases	NEURODEGENERATION, TUMOR, CELL DEATH, CANCER, PSORIASIS

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    T_CELLS["<b>T CELLS</b>"]
    T_CELLS -->|"contributes to"| Salivary_Gland_Damage["Salivary Gland Damage"]
    T_CELLS -->|"regulates"| Amyloid_plaque_accumulation["Amyloid plaque accumulation"]
    T_CELLS -->|"transports"| TUMOR["TUMOR"]
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| T_CELLS
    T_CELL["T CELL"] -->|"expressed in"| T_CELLS
    AQP4["AQP4"] -->|"activates"| T_CELLS
    B_CELL["B CELL"] -->|"activates"| T_CELLS
    PARP1["PARP1"] -->|"inhibits"| T_CELLS
    CELL_DEATH["CELL DEATH"] -->|"inhibits"| T_CELLS
    AUTOPHAGY["AUTOPHAGY"] -->|"transports"| T_CELLS
    CANCER["CANCER"] -->|"transports"| T_CELLS
    DNA_DAMAGE["DNA DAMAGE"] -->|"transports"| T_CELLS
    INFLAMMATION["INFLAMMATION"] -->|"expressed in"| T_CELLS
    FERROPTOSIS["FERROPTOSIS"] -->|"causes"| T_CELLS

Outgoing (138)

Target	Relation	Type	Str
NEURODEGENERATION	protects_against	phenotype	0.70
TUMOR	causes	disease	0.65
TUMOR	interacts_with	disease	0.65
TUMOR	targets	disease	0.65
TUMOR	increases	disease	0.65
CELL DEATH	targets	phenotype	0.65
CANCER	causes	disease	0.65
PSORIASIS	treats	disease	0.65
CYCLOPHOSPHAMIDE	treats	drug	0.65
CANCER	produces	disease	0.65
MTOR	treats	gene	0.65
TUMOR MICROENVIRONMENT	interacts_with	phenotype	0.65
TUMOR MICROENVIRONMENT	produces	phenotype	0.65
TUMOR MICROENVIRONMENT	treats	phenotype	0.65
ASTHMA	causes	disease	0.65
OLIGODENDROCYTE	activates	cell_type	0.65
DENTATE GYRUS	activates	brain_region	0.65
BACE1	regulates	gene	0.65
CYTOKINES	inhibits	phenotype	0.65
CYTOKINES	regulates	phenotype	0.65
CD33	produces	gene	0.65
GLIOBLASTOMA	causes	disease	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
DEMYELINATION	protects_against	phenotype	0.65
TDP-43	activates	gene	0.65
CYTOKINES	causes	phenotype	0.65
PECAM1	activates	gene	0.65
PECAM1	regulates	gene	0.65
TUMOR	transports	disease	0.60
TUMOR	contributes_to	disease	0.60
TUMOR	inhibits	disease	0.60
TUMOR	regulates	disease	0.60
TUMOR	protects_against	disease	0.60
TUMOR	promotes	disease	0.60
CANCER	stabilizes	disease	0.60
TBI	co_discussed	entity	0.50
ULK1	co_discussed	entity	0.50
CANCER	regulates	disease	0.50
AUTOPHAGY	regulates	process	0.50
AUTOPHAGY	associated_with	process	0.50
APOPTOSIS	associated_with	process	0.50
SENESCENCE	associated_with	process	0.50
MACROPHAGE	upregulates	cell_type	0.50
MACROPHAGES	upregulates	cell_type	0.50
NOTCH	activates	pathway	0.50
INFLAMMATION	regulates	process	0.50
RAPAMYCIN	regulates	drug	0.50
INFLAMMATION	inhibits	process	0.50
CANCER	activates	disease	0.50
MACROPHAGES	activates	cell_type	0.50

Incoming (715)

Source	Relation	Type	Str
CD4	interacts_with	gene	0.95
CD8	interacts_with	gene	0.95
NEOANTIGENS	activates	entity	0.80
INFLAMMATION	activates	process	0.80
CD8	activates	gene	0.80
B CELLS	interacts_with	cell_type	0.80
NOTCH	causes	gene	0.65
CANCER	expressed_in	disease	0.65
CANCER	targets	disease	0.65
NK CELL	activates	cell_type	0.65
MICROGLIA	accumulates_in	cell_type	0.65
T CELL	accumulates_in	cell_type	0.65
STING	causes	gene	0.65
NEUTROPHIL	increases	cell_type	0.65
ASTROCYTE	interacts_with	cell_type	0.65
ASTROCYTES	interacts_with	cell_type	0.65
NEURODEGENERATION	treats	disease	0.65
CANCER	treats	disease	0.65
NEURON	promotes	cell_type	0.65
NEURODEGENERATION	accumulates_in	disease	0.65
STING	targets	gene	0.65
MTOR	regulates	gene	0.65
MTOR	inhibits	gene	0.65
MYC	inhibits	gene	0.65
T CELL	reduces	cell_type	0.65
MTOR	reduces	gene	0.65
T CELL	mediates	cell_type	0.65
T CELL	transports	cell_type	0.65
P53	activates	gene	0.65
IL-6	activates	gene	0.65
ISCHEMIA	inhibits	disease	0.65
OCLN	inhibits	gene	0.65
P62	degrades	gene	0.65
T CELL	increases	cell_type	0.65
IL-6	associated_with	gene	0.65
CYTOKINES	activates	protein	0.65
B CELLS	activates	cell_type	0.65
CD8	expressed_in	gene	0.65
MYELOID CELLS	activates	cell_type	0.65
MYELOID CELLS	produces	cell_type	0.65
HIPPOCAMPUS	activates	brain_region	0.65
CDK5	inhibits	gene	0.65
CD33	activates	gene	0.65
NEURONS	causes	cell_type	0.65
CD33	targets	gene	0.65
NOTCH1	activates	gene	0.65
NOTCH1	regulates	gene	0.65
MS4A6A	activates	gene	0.65
PINK1	targets	gene	0.65
PLCG2	activates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

T CELLS

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

neuroinflammation

Pathway Diagram

Outgoing (138)

Incoming (715)

Targeting Hypotheses (0)

Mentioning Analyses (5)

Can metabolic interventions truly reverse established cellular senescence or onl

How do host cell factors influence the conformation and propagation properties o

What molecular mechanisms drive microglial senescence and the transition to dyst

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Related Papers (0)

T CELLS

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

neuroinflammation

Microglial Cells — Cell Type Hierarchy

GSK-3β in Neurodegeneration

Autophagy Mechanisms

Oligodendrocytes

Vitamin D Signaling Pathway in Neurodegeneration

rankings

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Spinal Cord Dorsal Horn Neurons

nlrc5-protein

dimethyl-fumarate-nrf2-ad-nct06850597

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

LRRK2 Pathway in Parkinson's Disease

CREB Signaling in Neurodegeneration

Amyloid Cascade Pathway

vitamin-d-therapy-neurodegeneration

Pathway Diagram

Outgoing (138)

Incoming (715)

Targeting Hypotheses (0)

Mentioning Analyses (5)

Can metabolic interventions truly reverse established cellular senescence or onl

How do host cell factors influence the conformation and propagation properties o

What molecular mechanisms drive microglial senescence and the transition to dyst

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Related Papers (0)