gene

NEUROG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

31Outgoing

18Incoming

Summary

Comprehensive page on NEUROG1 (Neurogenin-1), a bHLH transcription factor essential for neuronal development, sensory neuron differentiation, and implicated in neurodegeneration and regenerative medicine.

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🧬 Gene Info

Gene Symbol	NEUROG1
Full Name	Neurogenin-1
Chromosome	9q34.3
Protein Type	Transcription Factor
Function	is a Class A basic helix-loop-helix (bHLH) transcription factor that functions as a potent proneural gene essential for the development of specific neuronal populations.
Amino Acids	237 aa
Exons	2
Pathways	Epigenetic, epigenetic regulation, oxidative stress response
UniProt ID	Q96TT8
NCBI Gene ID	4744
Ensembl ID	ENSG00000181965
OMIM	605526
GeneCards	NEUROG1
Human Protein Atlas	NEUROG1
Encoded Protein	Neurogenin-1
Associated Diseases	neurodegeneration
Interactions	TP53, APC, PMS2, ARID1A, Rb, KRAS
KG Connections	49 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NEUROG1 — AlphaFold Q96TT8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NEUROG1["<b>NEUROG1</b>"]
    Cancer["Cancer"]
    NEUROG1 -->|"activates"| Cancer
    Aging["Aging"]
    NEUROG1 -->|"activates"| Aging
    Tumor["Tumor"]
    NEUROG1 -->|"biomarker for"| Tumor
    TP53["TP53"]
    NEUROG1 -->|"activates"| TP53
    APC["APC"]
    NEUROG1 -->|"activates"| APC
    DNA["DNA"]
    NEUROG1 -->|"biomarker for"| DNA
    MLH1["MLH1"]
    NEUROG1 -->|"biomarker for"| MLH1
    KRAS["KRAS"]
    NEUROG1 -->|"activates"| KRAS
    PMS2["PMS2"]
    NEUROG1 -->|"activates"| PMS2
    CACNA1G["CACNA1G"]
    NEUROG1 -->|"biomarker for"| CACNA1G
    Dna_Methylation["Dna Methylation"]
    NEUROG1 -->|"biomarker for"| Dna_Methylation
    Epigenetic["Epigenetic"]
    NEUROG1 -->|"activates"| Epigenetic
    CDKN2A["CDKN2A"]
    CDKN2A -->|"biomarker for"| NEUROG1
    ARID1A["ARID1A"]
    ARID1A -->|"activates"| NEUROG1
    APC["APC"]
    APC -->|"activates"| NEUROG1
    TP53["TP53"]
    TP53 -->|"activates"| NEUROG1
    DNA["DNA"]
    DNA -->|"biomarker for"| NEUROG1
    PMS2["PMS2"]
    PMS2 -->|"activates"| NEUROG1
    CACNA1G["CACNA1G"]
    CACNA1G -->|"biomarker for"| NEUROG1
    CANCER["CANCER"]
    CANCER -->|"activates"| NEUROG1
    AND["AND"]
    AND -->|"biomarker for"| NEUROG1
    neurodegeneration["neurodegeneration"]
    NEUROG1 -->|"implicated in"| neurodegeneration

Outgoing (31)

Target	Relation	Type	Str
Neurogranin	associated_with	protein	0.90
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Tumor	biomarker_for	disease	0.65
Aging	encodes	disease	0.65
Cancer	encodes	disease	0.65
TP53	activates	gene	0.60
APC	activates	gene	0.60
MLH1	biomarker_for	gene	0.60
PMS2	activates	gene	0.60
CACNA1G	biomarker_for	gene	0.60
TP53	encodes	gene	0.60
MLH1	methylates	gene	0.60
ARID1A	activates	gene	0.60
CDKN2A	biomarker_for	gene	0.60
Rb	activates	protein	0.60
DNA	biomarker_for	gene	0.60
KRAS	activates	gene	0.60
Dna Methylation	biomarker_for	pathway	0.60
Epigenetic	activates	pathway	0.60
Dna Methylation	methylates	pathway	0.60
Epigenetic	encodes	pathway	0.60
P53	encodes	protein	0.60
P53	activates	protein	0.60
Ras	activates	protein	0.60
epigenetic regulation	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
CDKN2A	associated_with	gene	0.50
CACNA1G	associated_with	protein	0.50
MLH1	associated_with	gene	0.50
Dna Methylation	associated_with	pathway	0.50

Incoming (18)

Source	Relation	Type	Str
CDKN2A	biomarker_for	gene	0.60
ARID1A	activates	gene	0.60
APC	activates	gene	0.60
TP53	activates	gene	0.60
PMS2	activates	gene	0.60
CACNA1G	biomarker_for	gene	0.60
CDKN2A	methylates	gene	0.60
ARID1A	encodes	gene	0.60
APC	encodes	gene	0.60
CACNA1G	methylates	gene	0.60
PMS2	encodes	gene	0.60
MLH1	biomarker_for	gene	0.60
DNA	biomarker_for	gene	0.60
CANCER	activates	gene	0.60
AND	biomarker_for	gene	0.60
KRAS	encodes	gene	0.60
DNA	methylates	gene	0.60
CACNA1G	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found