protein

NEUROGRANIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROGRANIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections
0Hypotheses
0Analyses
38Outgoing
25Incoming

Summary

NEUROGRANIN is a protein involved in neurodegeneration research. Key relationships include: biomarker for, implicated in, expressed in. Associated with ALS, Aging, Alzheimer. Connected to 17 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolNEUROGRANIN
FunctionNeurogranin is essential for synaptic plasticity through
Molecular Weight~8.7 kDa
PathwaysCalcium signaling, Amyloid, Blood-Brain Barrier
UniProt IDP84902
GeneCardsNEUROGRANIN
Human Protein AtlasNEUROGRANIN
GeneRC3 (Receptor Capping 3)
Protein NameNeurogranin
Brain ExpressionHippocampus, Cortex
Cellular LocalizationPostsynaptic dendritic spines
Associated DiseasesAls, Alzheimer, Neuroinflammation
InteractionsBDNF
KG Connections63 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Neurogranin (Ng) - Synaptic Biomarker

biomarker · 965 words

Novel Therapy Index

idea · 10647 words

Atypical Parkinsonism

disease · 6876 words

Corticobasal Degeneration (CBD)

disease · 5823 words

nhp-validation-animal-model

general · 5820 words

ALS Failed Approaches Analysis

mechanism · 4973 words

Pathway Diagram

graph TD
    NEUROGRANIN["<b>NEUROGRANIN</b>"]
    Neuroinflammation{"Neuroinflammation"}
    NEUROGRANIN -->|"biomarker for"| Neuroinflammation
    Aging{"Aging"}
    NEUROGRANIN -->|"biomarker for"| Aging
    Inflammation{"Inflammation"}
    NEUROGRANIN -->|"biomarker for"| Inflammation
    Alzheimer{"Alzheimer"}
    NEUROGRANIN -->|"biomarker for"| Alzheimer
    ALS{"ALS"}
    NEUROGRANIN -->|"biomarker for"| ALS
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROGRANIN -->|"biomarker for"| NEUROINFLAMMATION
    TAU["TAU"]
    NEUROGRANIN -->|"biomarker for"| TAU
    Amyloid(["Amyloid"])
    NEUROGRANIN -->|"biomarker for"| Amyloid
    AMYLOID["AMYLOID"]
    NEUROGRANIN -->|"biomarker for"| AMYLOID
    Neuron["Neuron"]
    NEUROGRANIN -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    NEUROGRANIN -->|"implicated in"| neurodegeneration
    AMYLOID -->|"biomarker for"| NEUROGRANIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"biomarker for"| NEUROGRANIN
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"biomarker for"| NEUROGRANIN
    NFL["NFL"]
    NFL -->|"biomarker for"| NEUROGRANIN
    BACE1["BACE1"]
    BACE1 -->|"biomarker for"| NEUROGRANIN
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"]
    SYNAPTOPHYSIN -->|"biomarker for"| NEUROGRANIN
    AND["AND"]
    AND -->|"biomarker for"| NEUROGRANIN
    style NEUROGRANIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

TargetRelationTypeStr
BDNFinteracts_withprotein0.85
Calcium signalingactivatespathway0.80
Neuroinflammationbiomarker_fordisease0.65
Agingbiomarker_fordisease0.65
Inflammationbiomarker_fordisease0.65

Incoming (26)

SourceRelationTypeStr
NFLbiomarker_forgene0.60
BACE1biomarker_forgene0.60
SYNAPTOPHYSINbiomarker_forgene0.60
TREM2biomarker_forgene0.60
SIGMA1therapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found