NFKBIE

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKBIE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NFKBIE encodes IκBε, a neuron-enriched NF-κB inhibitor isoform. Variants and expression changes modulate NF-κB activity in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

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graph TD
    NFKBIE["NFKBIE"]
    Aging{"Aging"}
    NFKBIE -->|"therapeutic_target"| Aging
    Als{"Als"}
    NFKBIE -->|"therapeutic_target"| Als
    Lymphoma{"Lymphoma"}
    NFKBIE -->|"therapeutic_target"| Lymphoma
    CDKN2A["CDKN2A"]
    NFKBIE -->|"interacts_with"| CDKN2A
    SMARCA4["SMARCA4"]
    NFKBIE -->|"interacts_with"| SMARCA4
    Epigenetic(["Epigenetic"])
    NFKBIE -->|"therapeutic_target"| Epigenetic
    Notch(["Notch"])
    NFKBIE -->|"interacts_with"| Notch
    CD19["CD19"]
    CD19 -->|"therapeutic_target"| NFKBIE
    TP53["TP53"]
    TP53 -->|"interacts_with"| NFKBIE
    SOX11["SOX11"]
    SOX11 -->|"therapeutic_target"| NFKBIE
    MYC["MYC"]
    MYC -->|"therapeutic_target"| NFKBIE
    AND["AND"]
    AND -->|"interacts_with"| NFKBIE
    KMT2D["KMT2D"]
    KMT2D -->|"interacts_with"| NFKBIE
    NSD2["NSD2"]
    NSD2 -->|"interacts_with"| NFKBIE
    NOTCH2["NOTCH2"]
    NOTCH2 -->|"interacts_with"| NFKBIE