Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SOX11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SOX11 encodes a transcription factor critical for neural development, neuronal differentiation, and neuroprotection in Alzheimer's and Parkinson's disease
| Gene Symbol | SOX11 |
| Full Name | SRY-Box Transcription Factor 11 |
| Chromosome | 2p25.2 |
| Protein Type | Transcription Factor |
| Function | is a member of the SOX (SRY-related HMG-box) family of transcription factors that play essential roles in neural development, neuronal differentiation, and cell fate specification. |
| Amino Acids | 497 aa |
| Pathways | Epigenetic |
| UniProt ID | [P35746](https://www.uniprot.org/uniprot/P35746) |
| Ensembl ID | ENSG00000175087 |
| GeneCards | SOX11 |
| Human Protein Atlas | SOX11 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | MYC, AND, CYCLIN D1 |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SOX11["SOX11"]
Aging{"Aging"}
SOX11 -->|"therapeutic_target"| Aging
Als{"Als"}
SOX11 -->|"therapeutic_target"| Als
Lymphoma{"Lymphoma"}
SOX11 -->|"therapeutic_target"| Lymphoma
MYC["MYC"]
SOX11 -->|"activates"| MYC
AND["AND"]
SOX11 -->|"activates"| AND
KMT2D["KMT2D"]
SOX11 -->|"therapeutic_target"| KMT2D
NSD2["NSD2"]
SOX11 -->|"therapeutic_target"| NSD2
NOTCH2["NOTCH2"]
SOX11 -->|"therapeutic_target"| NOTCH2
CYCLIN_D1["CYCLIN D1"]
SOX11 -->|"activates"| CYCLIN_D1
NFKBIE["NFKBIE"]
SOX11 -->|"therapeutic_target"| NFKBIE
CDKN2A["CDKN2A"]
SOX11 -->|"therapeutic_target"| CDKN2A
SMARCA4["SMARCA4"]
SOX11 -->|"therapeutic_target"| SMARCA4
Epigenetic(["Epigenetic"])
SOX11 -->|"activates"| Epigenetic
Notch(["Notch"])
SOX11 -->|"therapeutic_target"| Notch
CD19["CD19"]
CD19 -->|"therapeutic_target"| SOX11| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Lymphoma | therapeutic_target | disease | 0.65 |
| MYC | activates | gene | 0.60 |
| KMT2D | therapeutic_target | gene | 0.60 |
| NSD2 | therapeutic_target | gene | 0.60 |
| NOTCH2 | therapeutic_target | gene | 0.60 |
| NFKBIE | therapeutic_target | gene | 0.60 |
| CDKN2A | therapeutic_target | gene | 0.60 |
| SMARCA4 | therapeutic_target | gene | 0.60 |
| AND | activates | gene | 0.60 |
| CYCLIN D1 | activates | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Notch | therapeutic_target | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||