gene

SOX11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOX11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections
0Hypotheses
0Analyses
14Outgoing
2Incoming

Summary

SOX11 encodes a transcription factor critical for neural development, neuronal differentiation, and neuroprotection in Alzheimer's and Parkinson's disease

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🧬 Gene Info
Gene SymbolSOX11
Full NameSRY-Box Transcription Factor 11
Chromosome2p25.2
Protein TypeTranscription Factor
Functionis a member of the SOX (SRY-related HMG-box) family of transcription factors that play essential roles in neural development, neuronal differentiation, and cell fate specification.
Amino Acids497 aa
PathwaysEpigenetic
UniProt ID[P35746](https://www.uniprot.org/uniprot/P35746)
Ensembl IDENSG00000175087
GeneCardsSOX11
Human Protein AtlasSOX11
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsMYC, AND, CYCLIN D1
KG Connections16 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

SOX11 — SRY-Box Transcription Factor 11

gene · 911 words

Transcriptional Dysregulation in Neurodegeneration

mechanism · 2355 words

OSK Reprogramming and Yamanaka Factors in Neurodegeneration

mechanism · 1351 words

NFKBIE Gene

gene · 663 words

Genes

index · 271 words

Pathway Diagram

graph TD
    SOX11["SOX11"]
    Aging{"Aging"}
    SOX11 -->|"therapeutic_target"| Aging
    Als{"Als"}
    SOX11 -->|"therapeutic_target"| Als
    Lymphoma{"Lymphoma"}
    SOX11 -->|"therapeutic_target"| Lymphoma
    MYC["MYC"]
    SOX11 -->|"activates"| MYC
    AND["AND"]
    SOX11 -->|"activates"| AND
    KMT2D["KMT2D"]
    SOX11 -->|"therapeutic_target"| KMT2D
    NSD2["NSD2"]
    SOX11 -->|"therapeutic_target"| NSD2
    NOTCH2["NOTCH2"]
    SOX11 -->|"therapeutic_target"| NOTCH2
    CYCLIN_D1["CYCLIN D1"]
    SOX11 -->|"activates"| CYCLIN_D1
    NFKBIE["NFKBIE"]
    SOX11 -->|"therapeutic_target"| NFKBIE
    CDKN2A["CDKN2A"]
    SOX11 -->|"therapeutic_target"| CDKN2A
    SMARCA4["SMARCA4"]
    SOX11 -->|"therapeutic_target"| SMARCA4
    Epigenetic(["Epigenetic"])
    SOX11 -->|"activates"| Epigenetic
    Notch(["Notch"])
    SOX11 -->|"therapeutic_target"| Notch
    CD19["CD19"]
    CD19 -->|"therapeutic_target"| SOX11

Outgoing (14)

TargetRelationTypeStr
Agingtherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65
Lymphomatherapeutic_targetdisease0.65
MYCactivatesgene0.60
KMT2Dtherapeutic_targetgene0.60

Incoming (2)

SourceRelationTypeStr
CD19therapeutic_targetgene0.60
TP53therapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found