Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NSD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NSD2 |
| Full Name | Nuclear Receptor Binding SET Domain Protein 2 |
| Chromosome | 4p16.3 |
| Protein Type | Transferase |
| Function | encodes a histone lysine methyltransferase of the NSD family that catalyzes dimethylation of histone H3 at lysine 36 (H3K36me2). |
| Amino Acids | 1365 aa |
| Pathways | Cholesterol |
| UniProt ID | [O96028](https://www.uniprot.org/uniprot/O96028) |
| Ensembl ID | ENSG00000109685 |
| GeneCards | NSD2 |
| Human Protein Atlas | NSD2 |
| SET domain | The catalytic methyltransferase domain that specifically dimethylates H3K36 |
| PWWP domain | Reads existing H3K36 methylation marks, enabling processive methylation along gene bodies |
| PHD fingers (4x) | Recognize various histone tail modifications for chromatin context-dependent activity |
| HMG box | Provides non-sequence-specific DNA binding capability |
| Associated Diseases | Als, Hepatitis, Lymphoma |
| Interactions | MYC, NOTCH1, NOTCH2, NFKBIE, CDKN2A, SMARCA4 |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NSD2["<b>NSD2</b>"]
Hepatitis{"Hepatitis"}
NSD2 -->|"associated with"| Hepatitis
Lymphoma{"Lymphoma"}
NSD2 -->|"associated with"| Lymphoma
Als{"Als"}
NSD2 -->|"associated with"| Als
Cholesterol(["Cholesterol"])
NSD2 -->|"activates"| Cholesterol
Histone_Modification(["Histone Modification"])
NSD2 -->|"associated with"| Histone_Modification
TP53["TP53"]
NSD2 -->|"associated with"| TP53
MYC["MYC"]
NSD2 -->|"inhibits"| MYC
NF__B["NF-KappaB"]
NSD2 -->|"associated with"| NF__B
NOTCH1["NOTCH1"]
NSD2 -->|"inhibits"| NOTCH1
ATM["ATM"]
NSD2 -->|"associated with"| ATM
Nf__b(["Nf-Kappab"])
NSD2 -->|"associated with"| Nf__b
Notch(["Notch"])
NSD2 -->|"inhibits"| Notch
ERN1["ERN1"]
ERN1 -->|"activates"| NSD2
style NSD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| p65 | binds | transcription_factor | 0.80 |
| pancreatic tumorigenesis | inhibits | disease | 0.80 |
| NF-κB | inhibits | pathway | 0.80 |
| Hepatitis | associated_with | disease | 0.65 |
| Lymphoma | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Lymphoma | therapeutic_target | disease | 0.65 |
| TP53 | associated_with | gene | 0.60 |
| MYC | inhibits | gene | 0.60 |
| NOTCH1 | inhibits | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| NOTCH2 | interacts_with | gene | 0.60 |
| NFKBIE | interacts_with | gene | 0.60 |
| CDKN2A | interacts_with | gene | 0.60 |
| SMARCA4 | interacts_with | gene | 0.60 |
| Cholesterol | activates | pathway | 0.60 |
| Histone Modification | associated_with | pathway | 0.60 |
| NF-ΚB | associated_with | gene | 0.60 |
| Nf-Κb | associated_with | pathway | 0.60 |
| Notch | inhibits | pathway | 0.60 |
| CYCLIN D1 | therapeutic_target | gene | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Notch | interacts_with | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||