gene

SMARCA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMARCA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

325Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

SMARCA4 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, inhibits. Associated with AD, ALI, ALS. Connected to 193 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SMARCA4
Chromosome	19p13.2
Function	ATP-dependent chromatin remodeling ATPase
Primary Expression	the cerebral cortex, hippocampus, and cerebellum
Amino Acids	1647 aa
Exons	35
Gene Type	Protein-coding
Pathways	Epigenetic
NCBI Gene ID	6597
Ensembl ID	ENSG00000127616
GeneCards	SMARCA4
Human Protein Atlas	SMARCA4
HGNC ID	11100
Protein	BRG1 protein
Key Domains	QLQ, HSA, BRK, DEXDc, HELICc, Bromodomain
Associated Diseases	AD, ALI, AMI, Als, CRC, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ARID1A, APOB, TERT, IDH1, MET, JUN
SciDEX Hypotheses	Chromatin Remodeling-Mediated Nutrient Sensing Res
KG Connections	325 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Cancer["Cancer"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Ms["Ms"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Als["Als"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    IDH1["IDH1"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    VEGFA["VEGFA"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    MDM4["MDM4"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    APOB["APOB"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    style SMARCA4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (189)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
Wnt	therapeutic_target	pathway	0.70
DNA	associated_with	gene	0.70
Ms	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	activates	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
Cancer	contributes_to	disease	0.65
Renal Cell Carcinoma	contributes_to	disease	0.65
Carcinoma	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
Aging	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
TERT	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
EEF1A1	associated_with	gene	0.60
MCL1	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
AXIN2	regulates	gene	0.60

Incoming (136)

Source	Relation	Type	Str
h-var-a09491064e	targets_gene	hypothesis	0.90
VEGFA	therapeutic_target	gene	0.70
TERT	therapeutic_target	gene	0.70
IDH1	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
SF3B1	associated_with	gene	0.60
MET	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	regulates	gene	0.60
LEF1	therapeutic_target	gene	0.60
APOB	associated_with	gene	0.60
EEF1A1	associated_with	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
AXIN1	regulates	gene	0.60
CD44	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
MDM4	inhibits	gene	0.60
JUN	inhibits	gene	0.60
MET	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
APOB	inhibits	gene	0.60
CREBBP	regulates	gene	0.60
GAIN	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
RIPK2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
ASC	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
BRG1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
LC3	associated_with	gene	0.60
PTEN	contributes_to	gene	0.60
ARID1A	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Chromatin Remodeling-Mediated Nutrient Sensing Restoration	0.619	neurodegeneration	Epigenetic reprogramming in aging neuron

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SMARCA4

Understanding Entity Pages

Summary

Wiki Pages (21)

SMARCA4

Epigenetic Alterations in Alzheimer's Disease

Transcriptional Regulation in Neurodegeneration

chromatin-remodeling-neurodegeneration

Epigenetic Changes in PSP

Chromatin Remodeling in Neurodegeneration

SMARCA2 (BRM)

eef1a1

Wnt Signaling Dysfunction in Neurodegenerative Diseases

LEF1

Epigenetics in Amyotrophic Lateral Sclerosis

Epigenetics in Parkinson's Disease

Lactate Lactylation in Neurodegeneration

chd7-protein

CHD8 Gene

ASCL1 Gene

Section 200: Epigenetic and Chromatin Therapy in CBS/PSP

SMARCA2 Protein (BAF155)

SMARCB1 — SWI/SNF Related Matrix Associated Actin Dependent Regulator of Chromatin Subfamily B Member 1

Section 192 Advanced Epigenomics and Chromatin Therapy in CBS/PSP

DNA Methylation

Pathway Diagram

Outgoing (189)

Incoming (136)

Targeting Hypotheses (1)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)