gene

SMARCA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMARCA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

320Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

SMARCA4 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, inhibits. Associated with AD, ALI, ALS. Connected to 193 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SMARCA4
Chromosome	19p13.2
Function	ATP-dependent chromatin remodeling ATPase
Primary Expression	the cerebral cortex, hippocampus, and cerebellum
Amino Acids	1647 aa
Exons	35
Pathways	Epigenetic
Ensembl ID	ENSG00000127616
GeneCards	SMARCA4
Human Protein Atlas	SMARCA4
Associated Diseases	AD, ALI, Als, AMI, cancer
Known Drugs/Compounds	rapamycin
Interactions	AND, APOB, ARID1A, ASC, ATG, BECLIN1
SciDEX Hypotheses	Chromatin Remodeling-Mediated Nutrient Sensing Res
KG Connections	320 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SMARCA4

gene · 1049 words

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Pathway Diagram

graph TD
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Cancer["Cancer"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Ms["Ms"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Als["Als"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    IDH1["IDH1"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    VEGFA["VEGFA"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    MDM4["MDM4"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    APOB["APOB"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    style SMARCA4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (185)

Target	Relation	Type	Str
SWI/SNF complexes	regulates	complex	0.90
nucleosome remodeling	activates	process	0.90
Carcinoma	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
DNA	associated_with	gene	0.70
Wnt	therapeutic_target	pathway	0.70
Colorectal Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Ms	interacts_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Renal Cell Carcinoma	contributes_to	disease	0.65
Aging	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	associated_with	disease	0.65
TNF	associated_with	gene	0.60
RIPK3	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
ERN1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
ASC	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
MET	inhibits	gene	0.60
Rb	therapeutic_target	protein	0.60
SQSTM1	activates	gene	0.60
STAT3	activates	gene	0.60

Incoming (135)

Source	Relation	Type	Str
h-var-a09491064e	targets_gene	hypothesis	0.90
TERT	therapeutic_target	gene	0.70
VEGFA	therapeutic_target	gene	0.70
APOB	therapeutic_target	gene	0.60
SF3B1	associated_with	gene	0.60
MET	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	regulates	gene	0.60
LEF1	therapeutic_target	gene	0.60
STAT3	associated_with	gene	0.60
ASC	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
BRG1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
LC3	associated_with	gene	0.60
PTEN	contributes_to	gene	0.60
ARID1A	associated_with	gene	0.60
VHL	contributes_to	gene	0.60
CD19	therapeutic_target	gene	0.60
TP53	interacts_with	gene	0.60
SOX11	therapeutic_target	gene	0.60
KMT2D	interacts_with	gene	0.60
NSD2	interacts_with	gene	0.60
NOTCH2	interacts_with	gene	0.60
NFKBIE	interacts_with	gene	0.60
CDKN2A	interacts_with	gene	0.60
MCL1	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
ERN1	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
MELK	associated_with	gene	0.60
CLDN2	activates	gene	0.60
ADNP	expressed_in	gene	0.60
NLGN1	expressed_in	gene	0.60
NLGN2	expressed_in	gene	0.60
PAX6	expressed_in	gene	0.60
ACETYL-COA	contributes_to	gene	0.60
AMPK	contributes_to	gene	0.60
WNT	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Chromatin Remodeling-Mediated Nutrient Sensing Restoration	0.764	neurodegeneration	Epigenetic reprogramming in aging neuron

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 16 hypotheses Top: 0.779

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning SMARCA4 in their description or question text

No additional research found

SMARCA4

Understanding Entity Pages

Summary

Wiki Pages (1)

SMARCA4

Pathway Diagram

Outgoing (185)

Incoming (135)

Targeting Hypotheses (1)

Mentioning Analyses (1)

Epigenetic reprogramming in aging neurons

Experiments (0)

Related Papers (5)

Debates (3)

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

Epigenetic reprogramming in aging neurons

Related Research