NOTCH2

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NOTCH2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, associated with. Associated with Als, Alzheimer, Cancer. Connected to 124 entities in the SciDEX knowledge graph.

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graph TD
    NOTCH2["NOTCH2"]
    NOTCH2 -->|"activates"| Cancer["Cancer"]
    NOTCH2 -->|"target for"| Fibrosis["Fibrosis"]
    NOTCH2 -->|"target for"| Hepatitis["Hepatitis"]
    NOTCH2 -->|"target for"| Carcinoma["Carcinoma"]
    NOTCH2 -->|"target for"| Als["Als"]
    NOTCH2 -->|"target for"| Inflammation["Inflammation"]
    NOTCH2 -->|"target for"| Ms["Ms"]
    NOTCH2 -->|"target for"| Cardiac["Cardiac"]
    NOTCH2 -->|"target for"| Lymphoma["Lymphoma"]
    DLL4["DLL4"] -->|"inhibits"| NOTCH2
    LRP1["LRP1"] -->|"inhibits"| NOTCH2
    FGF20["FGF20"] -->|"target for"| NOTCH2
    BRG1["BRG1"] -->|"target for"| NOTCH2
    NRCAM["NRCAM"] -->|"target for"| NOTCH2
    ALDH1A1["ALDH1A1"] -->|"target for"| NOTCH2
    MITF["MITF"] -->|"target for"| NOTCH2
    LEF1["LEF1"] -->|"target for"| NOTCH2
    CANCER["CANCER"] -->|"target for"| NOTCH2
    CDH1["CDH1"] -->|"target for"| NOTCH2