Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NLRC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NLRC3 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with Inflammation, Ms. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | NLRC3 |
| Full Name | NLR Family CARD Domain Containing 3 |
| Chromosome | 16p13.3 |
| Protein Type | Receptor |
| Function | is a member of the NOD-like receptor (NLR) family of proteins. |
| Primary Expression | various tissues, with highest expression in immune cells and epithelial tissues |
| Molecular Weight | 85 kDa |
| Amino Acids | 755 aa |
| Exons | 14 |
| Pathways | Nf-Κb |
| UniProt ID | Q7RTV0 |
| NCBI Gene ID | 81128 |
| Ensembl ID | ENSG00000167900 |
| OMIM | 611362 |
| GeneCards | NLRC3 |
| Human Protein Atlas | NLRC3 |
| Associated Diseases | Ms |
| Interactions | TNF, NLRP3, STAT3, TLR4, TRAF6, INFLAMMATION |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NLRC3["<b>NLRC3</b>"]
Ms{"Ms"}
NLRC3 -->|"associated with"| Ms
Inflammation{"Inflammation"}
NLRC3 -->|"inhibits"| Inflammation
TNF["TNF"]
NLRC3 -->|"activates"| TNF
INFLAMMATION["INFLAMMATION"]
NLRC3 -->|"inhibits"| INFLAMMATION
NF__B["NF-KappaB"]
NLRC3 -->|"regulates"| NF__B
TRAF6["TRAF6"]
NLRC3 -->|"regulates"| TRAF6
APOPTOSIS["APOPTOSIS"]
NLRC3 -->|"activates"| APOPTOSIS
TNF__["TNF-Alpha"]
NLRC3 -->|"activates"| TNF__
Apoptosis(["Apoptosis"])
NLRC3 -->|"activates"| Apoptosis
Nf__b(["Nf-Kappab"])
NLRC3 -->|"regulates"| Nf__b
Adaptive_Immunity(["Adaptive Immunity"])
NLRC3 -->|"inhibits"| Adaptive_Immunity
neurodegeneration["neurodegeneration"]
NLRC3 -->|"implicated in"| neurodegeneration
style NLRC3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | suppresses | process | 0.85 |
| Neuroinflammation | inhibits | process | 0.80 |
| Ms | associated_with | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| TNF | activates | gene | 0.60 |
| TRAF6 | regulates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| TRAF6 | activates | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| NF-ΚB | regulates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| TNF-Α | activates | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Nf-Κb | regulates | pathway | 0.60 |
| Adaptive Immunity | inhibits | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| traumatic brain injury | activates | disease | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||