gene

NLRC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections
0Hypotheses
0Analyses
20Outgoing
2Incoming
0Experiments

Summary

NLRC3 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with Inflammation, Ms. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNLRC3
Full NameNLR Family CARD Domain Containing 3
Chromosome16p13.3
Protein TypeReceptor
Functionis a member of the NOD-like receptor (NLR) family of proteins.
Primary Expressionvarious tissues, with highest expression in immune cells and epithelial tissues
Molecular Weight85 kDa
Amino Acids755 aa
Exons14
PathwaysNf-Κb
UniProt IDQ7RTV0
NCBI Gene ID81128
Ensembl IDENSG00000167900
OMIM611362
GeneCardsNLRC3
Human Protein AtlasNLRC3
Associated DiseasesMs
InteractionsTNF, NLRP3, STAT3, TLR4, TRAF6, INFLAMMATION
KG Connections22 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NLRC3 — AlphaFold Q7RTV0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

NLRC3 — NLR Family CARD Domain Containing 3

gene · 1373 words

Muna Therapeutics

company · 3003 words

NLRC3 Protein

protein · 544 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    NLRC3["<b>NLRC3</b>"]
    Ms{"Ms"}
    NLRC3 -->|"associated with"| Ms
    Inflammation{"Inflammation"}
    NLRC3 -->|"inhibits"| Inflammation
    TNF["TNF"]
    NLRC3 -->|"activates"| TNF
    INFLAMMATION["INFLAMMATION"]
    NLRC3 -->|"inhibits"| INFLAMMATION
    NF__B["NF-KappaB"]
    NLRC3 -->|"regulates"| NF__B
    TRAF6["TRAF6"]
    NLRC3 -->|"regulates"| TRAF6
    APOPTOSIS["APOPTOSIS"]
    NLRC3 -->|"activates"| APOPTOSIS
    TNF__["TNF-Alpha"]
    NLRC3 -->|"activates"| TNF__
    Apoptosis(["Apoptosis"])
    NLRC3 -->|"activates"| Apoptosis
    Nf__b(["Nf-Kappab"])
    NLRC3 -->|"regulates"| Nf__b
    Adaptive_Immunity(["Adaptive Immunity"])
    NLRC3 -->|"inhibits"| Adaptive_Immunity
    neurodegeneration["neurodegeneration"]
    NLRC3 -->|"implicated in"| neurodegeneration
    style NLRC3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

TargetRelationTypeStr
Neuroinflammationsuppressesprocess0.85
Neuroinflammationinhibitsprocess0.80
Msassociated_withdisease0.65
Inflammationinhibitsdisease0.65
TNFactivatesgene0.60

Incoming (2)

SourceRelationTypeStr
MLCKactivatesgene0.60
AMPKactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found