concept

NORMAL TENSION GLAUCOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NORMAL TENSION GLAUCOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

29Outgoing

15Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NORMAL TENSION GLAUCOMA
Key Genes/Proteins	NEURODEGENERATION, OPTN, CHAT, ATXN2, ABCA1, CACNA1A
Related Diseases	Neurodegeneration, Als, Ms, Hypertension, Glaucoma

Wiki Pages (8)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NORMAL_TENSION_GLAUCOMA["NORMAL TENSION GLAUCOMA"]
    NORMAL_TENSION_GLAUCOMA -->|"activates"| Hypertension["Hypertension"]
    NORMAL_TENSION_GLAUCOMA -->|"activates"| MICROTUBULES["MICROTUBULES"]
    NORMAL_TENSION_GLAUCOMA -->|"activates"| KIF5B["KIF5B"]
    NORMAL_TENSION_GLAUCOMA -->|"activates"| MOTOR_NEURONS["MOTOR NEURONS"]
    NORMAL_TENSION_GLAUCOMA -->|"activates"| AXONAL_MITOCHONDRIAL_TRANSPORT["AXONAL MITOCHONDRIAL TRANSPORT"]
    NORMAL_TENSION_GLAUCOMA -->|"activates"| MITOCHONDRIA["MITOCHONDRIA"]
    NORMAL_TENSION_GLAUCOMA -->|"activates"| TRAK1["TRAK1"]
    NORMAL_TENSION_GLAUCOMA -->|"activates"| AXON_REGENERATION["AXON REGENERATION"]
    OPTN["OPTN"] -->|"risk_factor_for"| NORMAL_TENSION_GLAUCOMA
    AXON["AXON"] -->|"activates"| NORMAL_TENSION_GLAUCOMA
    TRAK1 -->|"activates"| NORMAL_TENSION_GLAUCOMA
    MITOCHONDRIA -->|"activates"| NORMAL_TENSION_GLAUCOMA
    MOTOR_NEURONS -->|"activates"| NORMAL_TENSION_GLAUCOMA
    KIF5B -->|"activates"| NORMAL_TENSION_GLAUCOMA
    AXON_REGENERATION -->|"activates"| NORMAL_TENSION_GLAUCOMA

Outgoing (29)

Target	Relation	Type	Str
Neurodegeneration	associated_with	disease	0.75
Als	associated_with	disease	0.75
NEURODEGENERATION	associated_with	gene	0.70
OPTN	associated_with	gene	0.70
Ms	associated_with	disease	0.65
Hypertension	activates	disease	0.65
Glaucoma	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
CHAT	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
FERMT2	associated_with	gene	0.60
DPM2	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
MICROTUBULES	activates	gene	0.60
KIF5B	activates	gene	0.60
ALS	associated_with	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AXONAL MITOCHONDRIAL TRANSPORT	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
TRAK1	activates	gene	0.60
AXON REGENERATION	activates	gene	0.60
AND	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
AXON	activates	gene	0.60
Spinal Cord	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (19)

Source	Relation	Type	Str
OPTN	associated_with	gene	0.90
AXON	activates	gene	0.60
ALS	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
TRAK1	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AND	associated_with	gene	0.60
KIF5B	activates	gene	0.60
OPTINEURIN	associated_with	gene	0.60
AXON REGENERATION	activates	gene	0.60
AXONAL MITOCHONDRIAL TRANSPORT	activates	gene	0.60
MICROTUBULES	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
GLAUCOMA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NORMAL TENSION GLAUCOMA

Understanding Entity Pages

Wiki Pages (8)

Gene-Mechanism-Therapy Causal Chains

OPTN Protein (Optineurin)

OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal Chain

Optineurin

retinal-ganglion-cells-glaucoma

OPTN — Optineurin