Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FERMT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FERMT2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | FERMT2 |
| Full Name | Fermitin Family Member 2 |
| Chromosome | 14q22.1 |
| Protein Type | Receptor |
| Function | encodes a member of the fermitin family of proteins. |
| Subcellular Localization | Kindlin-2 is prima |
| Molecular Weight | 80 kDa |
| Amino Acids | 683 aa |
| Pathways | Invasion, Wnt, Wnt/β-catenin signaling pathway |
| UniProt ID | Q9BUF5 |
| NCBI Gene ID | 10979 |
| Ensembl ID | ENSG00000173702 |
| OMIM | 614365 |
| GeneCards | FERMT2 |
| Human Protein Atlas | FERMT2 |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, CARCINOMA, Ms |
| Interactions | CELF1, ABCA7, CASS4, EPHA1, CLU, BIN1 |
| KG Connections | 120 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FERMT2["<b>FERMT2</b>"]
Als{"Als"}
FERMT2 -->|"associated with"| Als
Ms{"Ms"}
FERMT2 -->|"associated with"| Ms
OPTN["OPTN"]
FERMT2 -->|"associated with"| OPTN
GENES["GENES"]
FERMT2 -->|"associated with"| GENES
ABCA1["ABCA1"]
FERMT2 -->|"associated with"| ABCA1
DPM2["DPM2"]
FERMT2 -->|"associated with"| DPM2
TBK1["TBK1"]
FERMT2 -->|"associated with"| TBK1
neurodegeneration["neurodegeneration"]
FERMT2 -->|"implicated in"| neurodegeneration
ATXN2["ATXN2"]
ATXN2 -->|"associated with"| FERMT2
CACNA1A["CACNA1A"]
CACNA1A -->|"associated with"| FERMT2
CHAT["CHAT"]
CHAT -->|"associated with"| FERMT2
NORMAL_TENSION_GLAUCOMA["NORMAL TENSION GLAUCOMA"]
NORMAL_TENSION_GLAUCOMA -->|"associated with"| FERMT2
ABCA1 -->|"associated with"| FERMT2
TBK1 -->|"associated with"| FERMT2
OPTN -->|"associated with"| FERMT2
style FERMT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| OPTN | associated_with | gene | 0.60 |
| ABCA1 | associated_with | gene | 0.60 |
| DPM2 | associated_with | gene | 0.60 |
| TBK1 | associated_with | gene | 0.60 |
| RIN3 | associated_with | gene | 0.60 |
| ZCWPW1 | associated_with | gene | 0.60 |
| Wnt/β-catenin signaling pathway | activates | pathway | 0.60 |
| cancer incidence | contributes_to | phenotype | 0.60 |
| CRC prognosis | biomarker_for | phenotype | 0.60 |
| CELF1 | activates | gene | 0.60 |
| ABCA7 | activates | gene | 0.60 |
| CASS4 | activates | gene | 0.60 |
| EPHA1 | activates | gene | 0.60 |
| CLU | activates | gene | 0.60 |
| BIN1 | activates | gene | 0.60 |
| CD33 | activates | gene | 0.60 |
| CD2AP | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| INPP5D | interacts_with | gene | 0.60 |
| MEF2C | interacts_with | gene | 0.60 |
| NME8 | interacts_with | gene | 0.60 |
| PICALM | interacts_with | gene | 0.60 |
| PTK2B | interacts_with | gene | 0.60 |
| RIN3 | interacts_with | gene | 0.60 |
| SLC24A4 | interacts_with | gene | 0.60 |
| SORL1 | interacts_with | gene | 0.60 |
| ZCWPW1 | interacts_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| Alzheimer's disease | associated_with | disease | 0.60 |
| LNCRNA | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Epithelial | inhibits | cell_type | 0.60 |
| CANCER | activates | gene | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| Aβ | inhibits | protein | 0.60 |
| Ras | activates | protein | 0.60 |
| App | activates | protein | 0.60 |
| HLA | interacts_with | gene | 0.60 |
| MS4A | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| ATXN2 | associated_with | gene | 0.60 |
| CACNA1A | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| ABCA1 | associated_with | gene | 0.60 |
| TBK1 | associated_with | gene | 0.60 |
| OPTN | associated_with | gene | 0.60 |
| PLD3 | associated_with | gene | 0.60 |
| ABCA7 | associated_with | gene | 0.60 |
| SORL1 | associated_with | gene | 0.60 |
| PICALM | associated_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| TREM2 | associated_with | gene | 0.60 |
| CASS4 | associated_with | gene | 0.60 |
| CD33 | associated_with | gene | 0.60 |
| NME8 | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| CD2AP | associated_with | gene | 0.60 |
| INPP5D | associated_with | gene | 0.60 |
| EPHA1 | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| CELF1 | associated_with | gene | 0.60 |
| MEF2C | associated_with | gene | 0.60 |
| PTK2B | associated_with | gene | 0.60 |
| ZCWPW1 | activates | gene | 0.60 |
| ABCA7 | activates | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| CD2AP | activates | gene | 0.60 |
| EPHA1 | activates | gene | 0.60 |
| CLU | activates | gene | 0.60 |
| BIN1 | activates | gene | 0.60 |
| CASS4 | activates | gene | 0.60 |
| CD33 | activates | gene | 0.60 |
| ABCA7 | interacts_with | gene | 0.60 |
| BIN1 | interacts_with | gene | 0.60 |
| CASS4 | interacts_with | gene | 0.60 |
| CD2AP | interacts_with | gene | 0.60 |
| CD33 | interacts_with | gene | 0.60 |
| CELF1 | interacts_with | gene | 0.60 |
| CLU | interacts_with | gene | 0.60 |
| CR1 | interacts_with | gene | 0.60 |
| EPHA1 | interacts_with | gene | 0.60 |
| NORMAL TENSION GLAUCOMA | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| HLA | associated_with | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||