gene

FERMT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FERMT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

120Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

FERMT2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolFERMT2
Full NameFermitin Family Member 2
Chromosome14q22.1
Protein TypeReceptor
Functionencodes a member of the fermitin family of proteins.
Subcellular LocalizationKindlin-2 is prima
Molecular Weight80 kDa
Amino Acids683 aa
PathwaysInvasion, Wnt, Wnt/β-catenin signaling pathway
UniProt IDQ9BUF5
NCBI Gene ID10979
Ensembl IDENSG00000173702
OMIM614365
GeneCardsFERMT2
Human Protein AtlasFERMT2
Associated DiseasesAls, Alzheimer, Alzheimer's disease, CARCINOMA, Ms
InteractionsCELF1, ABCA7, CASS4, EPHA1, CLU, BIN1
KG Connections120 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: FERMT2 — AlphaFold Q9BUF5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

FERMT2 Gene

gene · 1145 words

Fermitin-2 (FERMT2 / Kindlin-2)

protein · 1167 words

DPM2 Gene (Dolichol-Phosphate Mannosyltransferase Subunit 2)

gene · 1091 words

CELF1 Gene

gene · 964 words

FERMT2 Protein

protein · 753 words

CACNA1A — Calcium Channel Alpha-1A Subunit

gene · 745 words

Pathway Diagram

graph TD
    FERMT2["<b>FERMT2</b>"]
    Als{"Als"}
    FERMT2 -->|"associated with"| Als
    Ms{"Ms"}
    FERMT2 -->|"associated with"| Ms
    OPTN["OPTN"]
    FERMT2 -->|"associated with"| OPTN
    GENES["GENES"]
    FERMT2 -->|"associated with"| GENES
    ABCA1["ABCA1"]
    FERMT2 -->|"associated with"| ABCA1
    DPM2["DPM2"]
    FERMT2 -->|"associated with"| DPM2
    TBK1["TBK1"]
    FERMT2 -->|"associated with"| TBK1
    neurodegeneration["neurodegeneration"]
    FERMT2 -->|"implicated in"| neurodegeneration
    ATXN2["ATXN2"]
    ATXN2 -->|"associated with"| FERMT2
    CACNA1A["CACNA1A"]
    CACNA1A -->|"associated with"| FERMT2
    CHAT["CHAT"]
    CHAT -->|"associated with"| FERMT2
    NORMAL_TENSION_GLAUCOMA["NORMAL TENSION GLAUCOMA"]
    NORMAL_TENSION_GLAUCOMA -->|"associated with"| FERMT2
    ABCA1 -->|"associated with"| FERMT2
    TBK1 -->|"associated with"| FERMT2
    OPTN -->|"associated with"| FERMT2
    style FERMT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (61)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
Alzheimerassociated_withdisease0.65
Alzheimeractivatesdisease0.65

Incoming (59)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
ATXN2associated_withgene0.60
CACNA1Aassociated_withgene0.60
CHATassociated_withgene0.60
ABCA1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found