Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ORAI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ORAI1 - Calcium Release-Activated Calcium Channel Protein 1 - store-operated calcium entry
| Gene Symbol | ORAI1 |
| Full Name | Calcium Release-Activated Calcium Channel Protein 1 |
| Chromosome | 12q24.31 |
| Primary Expression | T cells, Mast cells, Neurons, Astrocytes, Platelets |
| Molecular Weight | ~33 kDa |
| Amino Acids | 329 aa |
| Pathways | Angiogenesis, Notch |
| UniProt ID | Q8WTG4 |
| NCBI Gene ID | 84876 |
| Ensembl ID | ENSG00000182578 |
| OMIM | 610277 |
| GeneCards | ORAI1 |
| Human Protein Atlas | ORAI1 |
| Protein Length | 329 amino acids |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Immunodeficiency, Stroke |
| Interactions | NOTCH1, STIM1, PIEZO1 |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ORAI1["<b>ORAI1</b>"]
PIEZO1["PIEZO1"]
ORAI1 -->|"regulates"| PIEZO1
Notch(["Notch"])
ORAI1 -->|"regulates"| Notch
Angiogenesis(["Angiogenesis"])
ORAI1 -->|"activates"| Angiogenesis
ORAI1 -->|"regulates"| Angiogenesis
KLF2["KLF2"]
ORAI1 -->|"regulates"| KLF2
DTX1["DTX1"]
ORAI1 -->|"regulates"| DTX1
DTX3L["DTX3L"]
ORAI1 -->|"regulates"| DTX3L
NOTCH1["NOTCH1"]
ORAI1 -->|"regulates"| NOTCH1
Endothelial_Cell["Endothelial Cell"]
ORAI1 -->|"expressed in"| Endothelial_Cell
neurodegeneration["neurodegeneration"]
ORAI1 -->|"implicated in"| neurodegeneration
PIEZO1 -->|"regulates"| ORAI1
DTX1 -->|"regulates"| ORAI1
GENES["GENES"]
GENES -->|"regulates"| ORAI1
KLF2 -->|"regulates"| ORAI1
DTX3L -->|"regulates"| ORAI1
NOTCH1 -->|"regulates"| ORAI1
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"regulates"| ORAI1
AND["AND"]
AND -->|"regulates"| ORAI1
style ORAI1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| NOTCH1 | downregulates | gene | 0.90 |
| DTX1 | regulates | gene | 0.66 |
| DTX3L | regulates | gene | 0.66 |
| PIEZO1 | regulates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| PIEZO1 | activates | entity | 0.60 |
| UBIQUITIN | activates | entity | 0.60 |
| PIEZO1 | inhibits | entity | 0.60 |
| PIEZO1 | associated_with | entity | 0.60 |
| Notch | regulates | pathway | 0.60 |
| Angiogenesis | activates | pathway | 0.60 |
| Angiogenesis | regulates | pathway | 0.60 |
| GENES | regulates | gene | 0.60 |
| NOTCH | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| PIEZO | regulates | gene | 0.60 |
| Endothelial | regulates | cell_type | 0.60 |
| NOTCH1 | regulates | gene | 0.56 |
| KLF2 | regulates | gene | 0.56 |
| STIM1 | interacts_with | gene | 0.55 |
| Endothelial Cell | expressed_in | cell_type | 0.55 |
| NOTCH1 | activates | gene | 0.50 |
| NOTCH | activates | pathway | 0.50 |
| ENDOTHELIAL | activates | concept | 0.50 |
| ENDOTHELIAL CELLS | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIEZO1 | interacts_with | protein | 0.90 |
| PIEZO1 | regulates | gene | 0.74 |
| NOTCH1 | regulates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| NOTCH1 | activates | entity | 0.60 |
| DTX1 | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| KLF2 | regulates | gene | 0.60 |
| DTX3L | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| PIEZO | regulates | gene | 0.60 |
| NOTCH | regulates | gene | 0.60 |
| PIEZO1 | inhibits | gene | 0.50 |
| PIEZO1 | associated_with | gene | 0.50 |
| ZO1 | associated_with | gene | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||