concept

KLF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KLF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

53Connections

0Hypotheses

0Analyses

34Outgoing

19Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	KLF2
Key Genes/Proteins	IRF2BP2, PIEZO1, DTX3L, ORAI1, NOTCH1, PARP1
Related Diseases	Ms, Als, Inflammation
Related Pathways	NF-κB, Angiogenesis, Notch, Inflammasome

Wiki Pages (1)

Knowledge base pages for this entity

PECAM1 - Platelet Endothelial Cell Adhesion Molecule 1

gene · 1654 words

→

Pathway Diagram

graph TD
    KLF2["KLF2"]
    KLF2 -->|"inhibits"| NF__B["NF-kappaB"]
    KLF2 -->|"regulates"| Ms["Ms"]
    KLF2 -->|"expressed in"| Als["Als"]
    KLF2 -->|"expressed in"| Inflammation["Inflammation"]
    KLF2 -->|"regulates"| PIEZO1["PIEZO1"]
    KLF2 -->|"regulates"| DTX3L["DTX3L"]
    KLF2 -->|"regulates"| ORAI1["ORAI1"]
    IRF2BP2["IRF2BP2"] -->|"regulates"| KLF2
    PIEZO1 -->|"modulates"| KLF2
    DTX1["DTX1"] -->|"regulates"| KLF2
    GENES["GENES"] -->|"regulates"| KLF2
    DTX3L -->|"regulates"| KLF2
    CTCF["CTCF"] -->|"regulates"| KLF2
    PARP1["PARP1"] -->|"regulates"| KLF2

Outgoing (34)

Target	Relation	Type	Str
NF-κB	inhibits	pathway	0.80
Ms	regulates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
PIEZO1	regulates	gene	0.60
DTX3L	regulates	gene	0.60
ORAI1	regulates	gene	0.60
NOTCH1	regulates	gene	0.60
Angiogenesis	activates	pathway	0.60
Notch	regulates	pathway	0.60
Angiogenesis	regulates	pathway	0.60
PARP1	regulates	gene	0.60
Inflammasome	regulates	pathway	0.60
CTCF	regulates	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
MIRNAS	expressed_in	gene	0.60
UBIQUITIN	regulates	gene	0.60
GENES	regulates	gene	0.60
DTX1	regulates	gene	0.60
GENES	expressed_in	gene	0.60
IFN	expressed_in	gene	0.60
Cell Cycle	expressed_in	pathway	0.60
NOTCH	regulates	gene	0.60
AND	regulates	gene	0.60
PIEZO	regulates	gene	0.60
Endothelial	regulates	cell_type	0.60
NOTCH1	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
KLK1	associated_with	gene	0.60
KLK1	interacts_with	gene	0.60
PAH	interacts_with	gene	0.60
Endothelial Cell	expressed_in	cell_type	0.55

Incoming (19)

Source	Relation	Type	Str
IRF2BP2	regulates	gene	0.80
DTX1	regulates	gene	0.60
GENES	regulates	gene	0.60
DTX3L	regulates	gene	0.60
CTCF	regulates	gene	0.60
PARP1	regulates	gene	0.60
PIEZO1	regulates	gene	0.60
NOTCH1	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
AND	regulates	gene	0.60
PIEZO	regulates	gene	0.60
DTX1	activates	gene	0.60
DTX3L	activates	gene	0.60
APP	causes	gene	0.60
ABCC8	interacts_with	gene	0.60
ORAI1	regulates	gene	0.56
ZO1	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found