concept

PI3K/AKT/MTOR PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT/MTOR PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

0Analyses

50Outgoing

30Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PI3K/AKT/MTOR PATHWAY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PI3K_AKT_MTOR_PATHWAY["PI3K/AKT/MTOR PATHWAY"]
    PI3K_AKT_MTOR_PATHWAY -->|"involved_in"| Cancer["Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"contributes to"| Hormone_Receptor_Positive_Adva["Hormone Receptor-Positive Advanced Breast Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"involved_in"| Breast_Cancer["Breast Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| Tumor_Growth["Tumor Growth"]
    PI3K_AKT_MTOR_PATHWAY -->|"mediates"| Endocrine_Therapy_Resistance["Endocrine Therapy Resistance"]
    PI3K_AKT_MTOR_PATHWAY -->|"mediates"| Cdk4_6_Inhibitor_Resistance["Cdk4/6 Inhibitor Resistance"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| cell_survival["cell survival"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| dystrophic_neurites["dystrophic neurites"]
    Piperine["Piperine"] -->|"activates"| PI3K_AKT_MTOR_PATHWAY
    PIK3CA["PIK3CA"] -->|"involved_in"| PI3K_AKT_MTOR_PATHWAY
    CHRYSOTOXINE["CHRYSOTOXINE"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    Capivasertib["Capivasertib"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    Alpelisib["Alpelisib"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    MARCKS["MARCKS"] -->|"activates"| PI3K_AKT_MTOR_PATHWAY
    insulin_resistance["insulin resistance"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    STX11["STX11"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY

Outgoing (59)

Target	Relation	Type	Str
Hormone Receptor-Positive Advanced Breast Cancer	contributes_to	disease	0.95
Tumor Growth	promotes	process	0.95
Colorectal Cancer Initiation	involved_in	process	0.95
Colorectal Cancer Progression	involved_in	process	0.95
Colorectal Cancer Metastasis	promotes	process	0.95
Breast Tumorigenesis	involved_in	process	0.95
Cancer	involved_in	disease	0.95
Breast Cancer	involved_in	disease	0.95
Insulin Resistance	regulates	phenotype	0.95
Endocrine Therapy Resistance	mediates	mechanism	0.93
Cdk4/6 Inhibitor Resistance	mediates	mechanism	0.93
cell survival	promotes	process	0.92
dystrophic neurites	promotes	phenotype	0.92
insulin resistance	causes	phenotype	0.90
macrophage activation	regulates	phenotype	0.90
Transcriptional Targets	regulates	process	0.90
Gene Transcription	regulates	process	0.90
Tumor Growth	involved_in	process	0.90
protein turnover	regulates	process	0.90
cytoskeleton dynamics	regulates	process	0.90
lipid transport	regulates	process	0.90
axonal pathology	therapeutic_target	phenotype	0.90
Breast cancer	implicated_in	disease	0.90
Colorectal cancer	implicated_in	disease	0.90
Triple-negative breast cancer	implicated_in	disease	0.90
Endocrine Resistance	mediates	mechanism	0.90
Poor Prognosis	associated_with	phenotype	0.90
Pancreatic Ductal Adenocarcinoma	involved_in	disease	0.90
Cancer Progression	regulates	disease	0.90
Autophagy	mediates	process	0.90
Autophagy	mediates	process	0.90
Drug Resistance	mediates	phenotype	0.90
Sjogren's Syndrome	involved_in	disease	0.85
Tumor Invasion	involved_in	process	0.85
Idiopathic Pulmonary Fibrosis	involved_in	disease	0.85
Protein Turnover	regulates	process	0.85
Cytoskeleton Dynamics	regulates	process	0.85
Lipid Transport	regulates	process	0.85
Hormone-Receptor-Positive Breast Cancer	contributes_to	disease	0.85
Cancer Hallmarks	regulates	process	0.85
Cellular Growth	modulates	process	0.85
Cell Proliferation	regulates	process	0.85
Bladder Cancer	drives	disease	0.85
Apoptosis	regulates	process	0.85
Autophagy	regulates	process	0.85
Tumor Metastasis	associated_with	process	0.83
endocrine resistance	causes	phenotype	0.80
insulin resistance	protects_against	phenotype	0.80
Salivary Gland Damage	involved_in	phenotype	0.80
Cell Death	modulates	process	0.80

Incoming (30)

Source	Relation	Type	Str
Glioblastoma Multiforme	associated_with	disease	0.95
Piperine	activates	compound	0.95
PIK3CA	involved_in	gene	0.95
PI3K Pathway Inhibitors	inhibits	drug	0.95
Polyphenols	targets	compound	0.95
Apigenin	inhibits	compound	0.95
Capivasertib	inhibits	drug	0.92
Alpelisib	inhibits	drug	0.92
MARCKS	activates	protein	0.90
insulin resistance	inhibits	phenotype	0.90
STX11	inhibits	gene	0.90
PTEN	inhibits	protein	0.90
SPP1	activates	protein	0.90
PTEN	inhibits	gene	0.90
Piperine	activates	compound	0.90
Sijunzi Decoction	targets	drug	0.90
Berberine	inhibits	compound	0.90
Fibroblast Autophagy	inhibits	process	0.90
PIK3CA	associated_with	gene	0.90
PTEN	regulates	gene	0.90
Pi3K Inhibitors	inhibits	drug	0.90
Akt Inhibitors	inhibits	drug	0.90
Mtor Inhibitors	inhibits	drug	0.90
MTOR	involved_in	gene	0.88
AKT1	involved_in	gene	0.88
IRGM1	activates	protein	0.85
KRAS	activates	gene	0.85
NOBILETIN	inhibits	compound	0.80
RAF/MEK/ERK Pathway	interacts_with	pathway	0.75
Gomisin N	activates	compound	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PI3K/AKT/MTOR PATHWAY

Understanding Entity Pages

Wiki Pages (20)

nf1-protein

Remyelination in Neurodegeneration

Activity-Dependent Synaptic Plasticity in Neurodegeneration

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

PI3K/Akt Activator Clinical Trials for Parkinson's Disease

Microglial State Trajectory from Mobilization to Dysregulation in Alzheimer's Disease

mTOR Signaling in Autophagy and Lysosomal Function

ARRB2 — Arrestin Beta 2

fip200

PRKCI

EAAT2 Glutamate Transporter Rescue Therapy

TREM2-APOE Axis in Neurodegeneration

mTOR Signaling Dysregulation in Progressive Supranuclear Palsy

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

GFRA4 - GDNF Family Receptor Alpha 4

EGFR — Epidermal Growth Factor Receptor

mTOR Signaling Pathway in Neurodegeneration

PIK3CB — Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta