gene

STX11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STX11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

37Outgoing

12Incoming

Summary

Comprehensive information on STX11 (Syntaxin 11), a SNARE protein involved in intracellular trafficking and neurodegenerative diseases

View on Wiki →

🧬 Gene Info

Gene Symbol	STX11
Full Name	Syntaxin 11
Chromosome	6p21.31
Function	is a member of the syntaxin family of SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) proteins.
Primary Expression	immune cells and non-neuronal tissues, with lower expression in certain brain regions
Molecular Weight	~32 kDa
Amino Acids	288 aa
Pathways	Akt, Autophagy, PI3K-AKT-mTOR signaling, PI3K/AKT/mTOR, Pi3K/Akt
UniProt ID	O75560
NCBI Gene ID	6756
Ensembl ID	ENSG00000139289
OMIM	604396
GeneCards	STX11
Human Protein Atlas	STX11
Protein Length	288 amino acids
Associated Diseases	neurodegeneration
Interactions	SNAP25, AKT, BLM, PI3K, MTOR, AUTOPHAGY
KG Connections	49 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STX11 — AlphaFold O75560 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STX11["<b>STX11</b>"]
    fibroblast_activation["fibroblast activation"]
    STX11 -->|"inhibits"| fibroblast_activation
    PI3K_AKT_mTOR_pathway(["PI3K/AKT/mTOR pathway"])
    STX11 -->|"inhibits"| PI3K_AKT_mTOR_pathway
    SNAP25["SNAP25"]
    STX11 -->|"interacts with"| SNAP25
    autophagy(["autophagy"])
    STX11 -->|"activates"| autophagy
    pulmonary_fibrosis{"pulmonary fibrosis"}
    STX11 -->|"protects against"| pulmonary_fibrosis
    Fibrosis{"Fibrosis"}
    STX11 -->|"activates"| Fibrosis
    Akt(["Akt"])
    STX11 -->|"activates"| Akt
    Autophagy(["Autophagy"])
    STX11 -->|"activates"| Autophagy
    Mtor(["Mtor"])
    STX11 -->|"inhibits"| Mtor
    Pi3K(["Pi3K"])
    STX11 -->|"inhibits"| Pi3K
    AKT["AKT"]
    STX11 -->|"activates"| AKT
    BLM["BLM"]
    STX11 -->|"activates"| BLM
    AKT -->|"activates"| STX11
    BLM -->|"activates"| STX11
    MTOR["MTOR"]
    MTOR -->|"inhibits"| STX11
    PI3K["PI3K"]
    PI3K -->|"inhibits"| STX11
    SNAP25 -->|"activates"| STX11
    style STX11 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (37)

Target	Relation	Type	Str
Fibroblast Activation	inhibits	process	0.95
fibroblast activation	inhibits	phenotype	0.90
PI3K/AKT/mTOR pathway	inhibits	pathway	0.90
SNAP25	interacts_with	gene	0.90
autophagy	activates	pathway	0.90
pulmonary fibrosis	protects_against	disease	0.90
Idiopathic Pulmonary Fibrosis	protects_against	disease	0.90
TGF-β1-Induced Fibroblast Proliferation	inhibits	process	0.85
Fibroblast Migration	inhibits	process	0.85
Lung Tissues	expressed_in	cell_type	0.75
Fibrosis	activates	disease	0.65
AKT	activates	gene	0.60
BLM	activates	gene	0.60
SNAP25	activates	gene	0.60
PI3K	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
Akt	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Mtor	inhibits	pathway	0.60
Pi3K	inhibits	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
AND	activates	gene	0.60
Pi3K/Akt	activates	pathway	0.60
Fibroblast	activates	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
TGF	activates	gene	0.60
Fibroblast	expressed_in	cell_type	0.55
FIBROSIS	activates	disease	0.50
Pulmonary Fibrosis	activates	disease	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
FIBROBLASTS	activates	concept	0.50
TGF-Β1	activates	protein	0.50
MTOR SIGNALING	activates	concept	0.50

Incoming (12)

Source	Relation	Type	Str
AKT	activates	gene	0.60
BLM	activates	gene	0.60
MTOR	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
SNAP25	activates	gene	0.60
SNAP25	interacts_with	gene	0.60
PI3K	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AND	activates	gene	0.60
Pi3K	activates	pathway	0.50
mTOR	activates	entity	0.50
Autophagy	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found