Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IRGM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | promotes | process | 0.90 |
| Pi3K/Akt/Mtor | activates | pathway | 0.88 |
| anti-inflammatory response | regulates | process | 0.85 |
| PI3K/AKT/mTOR Pathway | activates | pathway | 0.85 |
| Inflammatory Cytokines | upregulates | biomarker | 0.85 |
| PI3K/AKT/mTOR | upstream_of | pathway | 0.85 |
| Inflammatory Cytokines | regulates | process | 0.80 |
| INFLAMMATION | inhibits | process | 0.80 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.70 |
| PI3K | inhibits | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MELK | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| NOD2 | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| PYCARD | activates | gene | 0.60 |
| RIPK2 | activates | gene | 0.60 |
| RIPK3 | activates | gene | 0.60 |
| SMARCA4 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| TNFA | activates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| RALGAPA2 | activates | gene | 0.60 |
| SNF | activates | gene | 0.60 |
| SWI | activates | gene | 0.60 |
| cancer | activates | disease | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| MAPK | activates | gene | 0.60 |
| NLR | activates | gene | 0.60 |
| NRBF2 | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| necroptosis | participates_in | pathway | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| benchmark_ot_ad_answer_key:IRGM1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BBR | targets | compound | 0.98 |
| BBR | binds_to | drug | 0.95 |
| Berberine | targets | compound | 0.95 |
| BBR | downregulates | compound | 0.95 |
| BBR | inhibits | drug | 0.90 |
| Berberine | downregulates | compound | 0.90 |
| AKT | inhibits | gene | 0.60 |
| ASC | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| BRG1 | activates | gene | 0.60 |
| ERN1 | activates | gene | 0.60 |
| CLDN2 | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| CCDC50 | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| IKK | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:IRGM1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||