Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPP1CA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PPP1CA is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Cancer, Carcinoma, Ms. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | PPP1CA |
| Full Name | ppp1ca |
| Aliases | Protein Phosphatase 1 Alpha |
| Chromosome | 11q13.4 |
| Protein Type | Gene |
| Function | [@sachidanandam2017] |
| Primary Expression | neurons and glia |
| Subcellular Localization | **: Predominantly cytoplasmic, with nuclear localization in some cell types |
| Molecular Weight | 37 kDa |
| Amino Acids | 330 aa |
| Exons | 7 |
| Pathways | Akt, Mtor |
| NCBI Gene ID | Search NCBI |
| GeneCards | PPP1CA |
| Human Protein Atlas | PPP1CA |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, CANCER, AMPK, VHL, MTOR, LUZP1 |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
PPP1CA["<b>PPP1CA</b>"]
Carcinoma{"Carcinoma"}
PPP1CA -->|"activates"| Carcinoma
Ms{"Ms"}
PPP1CA -->|"activates"| Ms
Cancer{"Cancer"}
PPP1CA -->|"activates"| Cancer
Tumor{"Tumor"}
PPP1CA -->|"activates"| Tumor
AKT["AKT"]
PPP1CA -->|"activates"| AKT
CANCER["CANCER"]
PPP1CA -->|"activates"| CANCER
Akt(["Akt"])
PPP1CA -->|"activates"| Akt
Mtor(["Mtor"])
PPP1CA -->|"activates"| Mtor
neurodegeneration["neurodegeneration"]
PPP1CA -->|"implicated in"| neurodegeneration
VHL["VHL"]
VHL -->|"activates"| PPP1CA
MTOR["MTOR"]
MTOR -->|"activates"| PPP1CA
style PPP1CA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| AMPK | activates | protein | 0.85 |
| Carcinoma | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| AKT | activates | gene | 0.60 |
| VPS29 | targets | gene | 0.60 |
| VPS35 | targets | gene | 0.60 |
| YBX1 | targets | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| Akt | activates | pathway | 0.60 |
| Mtor | activates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||