gene

PPP1CA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1CA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections
0Hypotheses
0Analyses
12Outgoing
8Incoming

Summary

PPP1CA is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Cancer, Carcinoma, Ms. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolPPP1CA
Full Nameppp1ca
AliasesProtein Phosphatase 1 Alpha
Chromosome11q13.4
Protein TypeGene
Function[@sachidanandam2017]
Primary Expressionneurons and glia
Subcellular Localization**: Predominantly cytoplasmic, with nuclear localization in some cell types
Molecular Weight37 kDa
Amino Acids330 aa
Exons7
PathwaysAkt, Mtor
NCBI Gene IDSearch NCBI
GeneCardsPPP1CA
Human Protein AtlasPPP1CA
Associated Diseasesneurodegeneration
InteractionsAKT, CANCER, AMPK, VHL, MTOR, LUZP1
KG Connections20 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

ppp1ca

gene · 1165 words

Epigenetic Mechanisms in Alzheimer's Disease

mechanism · 3425 words

PPP1R15B

gene · 2982 words

Non-coding RNAs in Neurodegeneration

mechanism · 2937 words

Brain Hyperconnectivity-Tau Spread Hypothesis in Alzheimer's Disease

hypothesis · 2126 words

CYP27B1 — Vitamin D 1-alpha Hydroxylase

gene · 1954 words

Pathway Diagram

graph TD
    PPP1CA["<b>PPP1CA</b>"]
    Carcinoma{"Carcinoma"}
    PPP1CA -->|"activates"| Carcinoma
    Ms{"Ms"}
    PPP1CA -->|"activates"| Ms
    Cancer{"Cancer"}
    PPP1CA -->|"activates"| Cancer
    Tumor{"Tumor"}
    PPP1CA -->|"activates"| Tumor
    AKT["AKT"]
    PPP1CA -->|"activates"| AKT
    CANCER["CANCER"]
    PPP1CA -->|"activates"| CANCER
    Akt(["Akt"])
    PPP1CA -->|"activates"| Akt
    Mtor(["Mtor"])
    PPP1CA -->|"activates"| Mtor
    neurodegeneration["neurodegeneration"]
    PPP1CA -->|"implicated in"| neurodegeneration
    VHL["VHL"]
    VHL -->|"activates"| PPP1CA
    MTOR["MTOR"]
    MTOR -->|"activates"| PPP1CA
    style PPP1CA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

TargetRelationTypeStr
AMPKactivatesprotein0.85
Carcinomaactivatesdisease0.65
Msactivatesdisease0.65
Canceractivatesdisease0.65
Tumoractivatesdisease0.65

Incoming (9)

SourceRelationTypeStr
LUZP1interacts_withprotein0.88
VHLactivatesgene0.60
MTORactivatesgene0.60
BECN1targetsgene0.60
CYP27B1targetsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found