Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RTN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive information about RTN1, a neuron-specific reticulon protein involved in ER morphology, neuroendocrine secretion, and implicated in ALS and Alzheimer's disease.
| Gene Symbol | RTN1 |
| Full Name | Reticulon 1 |
| Aliases | Reticulon-1 |
| Chromosome | 19q13.32 |
| Function | encodes a member of the reticulon family of proteins that are primarily localized to the endoplasmic reticulum (ER). |
| Primary Expression | neurons and is involved in shaping the tubular ER network, neuroendocrine secretory granule formation, and synaptic function |
| Subcellular Localization | the endoplasmic reticulum (ER). Unlike its better-known relative RTN4 (Nogo), RTN1 is predominantly expressed in neurons |
| Amino Acids | 200 aa |
| Gene Type | Protein-coding |
| UniProt ID | Q86VR8 |
| NCBI Gene ID | 19740 |
| Ensembl ID | ENSG00000131871 |
| OMIM | 603123 |
| GeneCards | RTN1 |
| Human Protein Atlas | RTN1 |
| Associated Diseases | Alzheimer, Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases, PARKINSON'S DISEASE, Parkinson, disease |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RTN1["<b>RTN1</b>"]
Alzheimer["Alzheimer"]
RTN1 -->|"therapeutic target"| Alzheimer
Als["Als"]
RTN1 -->|"therapeutic target"| Als
Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
RTN1 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
Parkinson["Parkinson"]
RTN1 -->|"therapeutic target"| Parkinson
Parkinson["Parkinson"]
RTN1 -->|"associated with"| Parkinson
Alzheimer["Alzheimer"]
RTN1 -->|"associated with"| Alzheimer
Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
RTN1 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
SNAP25["SNAP25"]
RTN1 -->|"associated with"| SNAP25
PARKINSON["PARKINSON"]
RTN1 -->|"therapeutic target"| PARKINSON
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
RTN1 -->|"associated with"| NEURODEGENERATIVE_DISEASES
AND["AND"]
RTN1 -->|"associated with"| AND
CHN1["CHN1"]
RTN1 -->|"associated with"| CHN1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
RTN1 -->|"associated with"| ALZHEIMER_S_DISEASE
MICRORNAS["MICRORNAS"]
RTN1 -->|"associated with"| MICRORNAS
ALS["ALS"]
RTN1 -->|"associated with"| ALS
PI3K["PI3K"]
RTN1 -->|"associated with"| PI3K
NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
RTN1 -->|"associated with"| NEURODEGENERATIVE_DISORDERS
MICRORNAS["MICRORNAS"]
MICRORNAS -->|"therapeutic target"| RTN1
CHN1["CHN1"]
CHN1 -->|"associated with"| RTN1
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"therapeutic target"| RTN1
ALS["ALS"]
ALS -->|"therapeutic target"| RTN1
MDH1["MDH1"]
MDH1 -->|"associated with"| RTN1
GENES["GENES"]
GENES -->|"associated with"| RTN1
AKT["AKT"]
AKT -->|"associated with"| RTN1
AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
AMYOTROPHIC_LATERAL_SCLEROSIS -->|"associated with"| RTN1
PARKINSON["PARKINSON"]
PARKINSON -->|"associated with"| RTN1
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"associated with"| RTN1
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| RTN1
neurodegeneration["neurodegeneration"]
RTN1 -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| PARKINSON'S DISEASE | associated_with | disease | 0.85 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | therapeutic_target | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 0.65 |
| SNAP25 | associated_with | gene | 0.60 |
| CHN1 | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| MDH1 | associated_with | gene | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| MICRORNAS | associated_with | gene | 0.60 |
| ALS | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| MICRORNAS | therapeutic_target | gene | 0.60 |
| ALS | therapeutic_target | gene | 0.60 |
| Akt | therapeutic_target | protein | 0.60 |
| Pi3K | therapeutic_target | protein | 0.60 |
| Neurodegenerative Diseases | associated_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CHN1 | associated_with | gene | 0.60 |
| MDH1 | associated_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| MICRORNAS | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| ALS | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| SNAP25 | associated_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||