Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MDH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MDH1 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, inhibits. Associated with ALS, Als, Alzheimer. Connected to 68 entities in the SciDEX knowledge graph.
| Gene Symbol | MDH1 |
| Full Name | Malate Dehydrogenase 1 |
| Chromosome | 2p13.3 |
| Protein Type | Enzyme |
| Function | is a cytosolic enzyme that catalyzes the reversible conversion of malate to oxaloacetate using NAD⁺/NADH as cofactors[@minarik2002]. |
| Primary Expression | all tissues: |
| Amino Acids | 334 aa |
| Exons | 9 |
| Ensembl ID | ENSG00000070785 |
| GeneCards | MDH1 |
| Human Protein Atlas | MDH1 |
| NAD⁺-binding domain | Rossmann fold for cofactor binding |
| Dimerization domain | Forms active homodimer |
| Active site | Contains catalytic residues for malate/oxaloacetate conversion |
| Cytosolic localization | No mitochondrial targeting sequence |
| Associated Diseases | Als, Alzheimer, Amyotrophic Lateral Sclerosis, Inflammation, Ms, Neurodegenerative Diseases |
| Interactions | BDNF, IDH1, AND, CYTOKINES, Aβ, Bdnf |
| KG Connections | 130 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
MDH1["MDH1"] -->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
MDH1["MDH1"] -->|"biomarker for"| Als["Als"]
MDH1["MDH1"] -->|"biomarker for"| Inflammation["Inflammation"]
MDH1["MDH1"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
MDH1["MDH1"] -->|"biomarker for"| Alzheimer["Alzheimer"]
MDH1["MDH1"] -->|"associated with"| Inflammation["Inflammation"]
MDH1["MDH1"] -->|"associated with"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
MDH1["MDH1"] -->|"associated with"| Als["Als"]
MDH1["MDH1"] -->|"associated with"| Ms["Ms"]
MDH1["MDH1"] -->|"biomarker for"| ALS["ALS"]
MDH1["MDH1"] -->|"biomarker for"| PDGFRB["PDGFRB"]
MDH1["MDH1"] -->|"biomarker for"| SQSTM1["SQSTM1"]
style MDH1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
style Traumatic_Brain_Injury fill:#ef5350,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
style PDGFRB fill:#4a1a6b,stroke:#333,color:#e0e0e0
style SQSTM1 fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | biomarker_for | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Inflammation | biomarker_for | disease | 0.65 |
| Neuroinflammation | biomarker_for | disease | 0.65 |
| Alzheimer | biomarker_for | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Traumatic Brain Injury | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| ALS | biomarker_for | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | therapeutic_target | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 0.65 |
| PDGFRB | biomarker_for | gene | 0.60 |
| SQSTM1 | biomarker_for | gene | 0.60 |
| BDNF | inhibits | gene | 0.60 |
| APOE | biomarker_for | gene | 0.60 |
| NEFL | biomarker_for | gene | 0.60 |
| CHI3L1 | biomarker_for | gene | 0.60 |
| IL9 | biomarker_for | gene | 0.60 |
| IL4 | biomarker_for | gene | 0.60 |
| NPTX1 | biomarker_for | gene | 0.60 |
| VEGFA | biomarker_for | gene | 0.60 |
| GFAP | biomarker_for | gene | 0.60 |
| S100B | biomarker_for | gene | 0.60 |
| PSEN1 | biomarker_for | gene | 0.60 |
| IL16 | associated_with | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| CHIT1 | biomarker_for | gene | 0.60 |
| FGF2 | biomarker_for | gene | 0.60 |
| TAU | biomarker_for | gene | 0.60 |
| RTN1 | associated_with | gene | 0.60 |
| SNAP25 | associated_with | gene | 0.60 |
| CHN1 | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| Vegf | biomarker_for | protein | 0.60 |
| Rb | biomarker_for | protein | 0.60 |
| IDH1 | activates | gene | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| Autophagy | biomarker_for | pathway | 0.60 |
| Amyloid | biomarker_for | pathway | 0.60 |
| AUTOPHAGY | biomarker_for | gene | 0.60 |
| BRAIN INJURY | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | biomarker_for | gene | 0.60 |
| NEUROINFLAMMATION | biomarker_for | gene | 0.60 |
| Cerebrovascular | biomarker_for | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| IL9 | biomarker_for | gene | 0.60 |
| VEGFA | biomarker_for | gene | 0.60 |
| IL4 | biomarker_for | gene | 0.60 |
| FGF2 | biomarker_for | gene | 0.60 |
| GFAP | biomarker_for | gene | 0.60 |
| NPTX1 | biomarker_for | gene | 0.60 |
| CHIT1 | biomarker_for | gene | 0.60 |
| SQSTM1 | biomarker_for | gene | 0.60 |
| NEFL | biomarker_for | gene | 0.60 |
| CHI3L1 | biomarker_for | gene | 0.60 |
| APOE | biomarker_for | gene | 0.60 |
| BDNF | inhibits | gene | 0.60 |
| S100B | biomarker_for | gene | 0.60 |
| PSEN1 | biomarker_for | gene | 0.60 |
| PDGFRB | biomarker_for | gene | 0.60 |
| TAU | biomarker_for | gene | 0.60 |
| BDNF | biomarker_for | entity | 0.60 |
| IL16 | associated_with | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| CHN1 | associated_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| RTN1 | associated_with | gene | 0.60 |
| SNAP25 | associated_with | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| AMYLOID-BETA | biomarker_for | gene | 0.60 |
| CYTOKINES | biomarker_for | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AMYLOID | biomarker_for | gene | 0.60 |
| ALZHEIMER | biomarker_for | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | biomarker_for | gene | 0.60 |
| TAU PATHOLOGY | biomarker_for | gene | 0.60 |
| INFLAMMATION | biomarker_for | gene | 0.60 |
| NEURODEGENERATION | biomarker_for | gene | 0.60 |
| CYTOKINES | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | biomarker_for | gene | 0.60 |
| NEUROINFLAMMATION | biomarker_for | gene | 0.60 |
| BRAIN INJURY | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| CCL2 | biomarker_for | gene | 0.60 |
| MICRORNAS | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| ALS | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| DMSO | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||