gene

MDH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MDH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

130Connections
0Hypotheses
0Analyses
50Outgoing
48Incoming

Summary

MDH1 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, inhibits. Associated with ALS, Als, Alzheimer. Connected to 68 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolMDH1
Full NameMalate Dehydrogenase 1
Chromosome2p13.3
Protein TypeEnzyme
Functionis a cytosolic enzyme that catalyzes the reversible conversion of malate to oxaloacetate using NAD⁺/NADH as cofactors[@minarik2002].
Primary Expressionall tissues:
Amino Acids334 aa
Exons9
Ensembl IDENSG00000070785
GeneCardsMDH1
Human Protein AtlasMDH1
NAD⁺-binding domainRossmann fold for cofactor binding
Dimerization domainForms active homodimer
Active siteContains catalytic residues for malate/oxaloacetate conversion
Cytosolic localizationNo mitochondrial targeting sequence
Associated DiseasesAls, Alzheimer, Amyotrophic Lateral Sclerosis, Inflammation, Ms, Neurodegenerative Diseases
InteractionsBDNF, IDH1, AND, CYTOKINES, , Bdnf
KG Connections130 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

MDH1 — Malate Dehydrogenase 1

gene · 838 words

NPTX1 Protein

protein · 2155 words

GOT1 Gene

gene · 1853 words

SLC25A12 Protein

protein · 1703 words

CHN1 — Chimerin 1

gene · 1631 words

RTN1 Gene (Reticulon 1)

gene · 1534 words

Pathway Diagram

flowchart TD
    MDH1["MDH1"] -->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
    MDH1["MDH1"] -->|"biomarker for"| Als["Als"]
    MDH1["MDH1"] -->|"biomarker for"| Inflammation["Inflammation"]
    MDH1["MDH1"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    MDH1["MDH1"] -->|"biomarker for"| Alzheimer["Alzheimer"]
    MDH1["MDH1"] -->|"associated with"| Inflammation["Inflammation"]
    MDH1["MDH1"] -->|"associated with"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    MDH1["MDH1"] -->|"associated with"| Als["Als"]
    MDH1["MDH1"] -->|"associated with"| Ms["Ms"]
    MDH1["MDH1"] -->|"biomarker for"| ALS["ALS"]
    MDH1["MDH1"] -->|"biomarker for"| PDGFRB["PDGFRB"]
    MDH1["MDH1"] -->|"biomarker for"| SQSTM1["SQSTM1"]
    style MDH1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Traumatic_Brain_Injury fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style PDGFRB fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SQSTM1 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (82)

TargetRelationTypeStr
Neurodegenerationbiomarker_fordisease0.65
Alsbiomarker_fordisease0.65
Inflammationbiomarker_fordisease0.65
Neuroinflammationbiomarker_fordisease0.65
Alzheimerbiomarker_fordisease0.65

Incoming (48)

SourceRelationTypeStr
IL9biomarker_forgene0.60
VEGFAbiomarker_forgene0.60
IL4biomarker_forgene0.60
FGF2biomarker_forgene0.60
GFAPbiomarker_forgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found