gene

SEC22B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEC22B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections
0Hypotheses
0Analyses
16Outgoing
12Incoming

Summary

SEC22B (Synaptotagmin Binding Protein) - SNARE protein involved in ER-Golgi vesicle trafficking, synaptic function, and neurodegenerative disease mechanisms

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🧬 Gene Info
Gene SymbolSEC22B
Full NameSynaptotagmin Binding Protein
Chromosome1q21.2
Functionis a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) protein family that plays essential roles in intracellular membrane trafficking.
Amino Acids215 aa
PathwaysAutophagy
UniProt ID[O75396](https://www.uniprot.org/uniprot/O75396)
Ensembl IDENSG00000169933
OMIM607048
GeneCardsSEC22B
Human Protein AtlasSEC22B
N-terminal transmembrane regionA short helical transmembrane domain that anchors the protein to vesicle membranes
SNARE motifA conserved region of approximately 60-70 amino acids that participates in SNARE complex formation
Proline-rich domainLocated in the central region, involved in protein-protein interactions
C-terminal variable regionContributes to specificity in SNARE pairing
Associated Diseasesneurodegeneration
InteractionsSQSTM1, TH, WDR45, XBP1, RTN3
KG Connections28 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SEC22B Gene

gene · 1791 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["SEC22B"]
    N1["Alzheimer"]
    N0 -->|"regulates"| N1
    N2["Neurodegeneration"]
    N0 -->|"regulates"| N2
    N3["Cancer"]
    N0 -->|"regulates"| N3
    N4["Als"]
    N0 -->|"regulates"| N4
    N5["Neuroinflammation"]
    N0 -->|"regulates"| N5
    N6["SNAP23"]
    N0 -->|"regulates"| N6
    N7["Autophagy"]
    N0 -->|"regulates"| N7
    N8["Microglia"]
    N0 -->|"regulates"| N8
    N9["HSP90"]
    N9 -->|"regulates"| N0
    N10["ALZHEIMER"]
    N10 -->|"regulates"| N0
    N11["SNAP29"]
    N11 -->|"regulates"| N0
    N12["MICROGLIA"]
    N12 -->|"regulates"| N0
    N13["LYSOSOME"]
    N13 -->|"regulates"| N0
    N14["STX4"]
    N14 -->|"regulates"| N0

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 disease
    class N5 disease
    class N6 gene
    class N7 pathway
    class N9 gene
    class N10 gene
    class N11 gene
    class N12 gene
    class N13 gene
    class N14 gene

Outgoing (16)

TargetRelationTypeStr
Alzheimerregulatesdisease0.65
Neurodegenerationregulatesdisease0.65
Cancerregulatesdisease0.65
Alsregulatesdisease0.65
Neuroinflammationregulatesdisease0.65

Incoming (12)

SourceRelationTypeStr
HSP90regulatesgene0.60
SNAP29regulatesgene0.60
STX4regulatesgene0.60
STX3regulatesgene0.60
FKBP5regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found