Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SEC22B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SEC22B (Synaptotagmin Binding Protein) - SNARE protein involved in ER-Golgi vesicle trafficking, synaptic function, and neurodegenerative disease mechanisms
| Gene Symbol | SEC22B |
| Full Name | Synaptotagmin Binding Protein |
| Chromosome | 1q21.2 |
| Function | is a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) protein family that plays essential roles in intracellular membrane trafficking. |
| Amino Acids | 215 aa |
| Pathways | Autophagy |
| UniProt ID | [O75396](https://www.uniprot.org/uniprot/O75396) |
| Ensembl ID | ENSG00000169933 |
| OMIM | 607048 |
| GeneCards | SEC22B |
| Human Protein Atlas | SEC22B |
| N-terminal transmembrane region | A short helical transmembrane domain that anchors the protein to vesicle membranes |
| SNARE motif | A conserved region of approximately 60-70 amino acids that participates in SNARE complex formation |
| Proline-rich domain | Located in the central region, involved in protein-protein interactions |
| C-terminal variable region | Contributes to specificity in SNARE pairing |
| Associated Diseases | neurodegeneration |
| Interactions | SQSTM1, TH, WDR45, XBP1, RTN3 |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["SEC22B"]
N1["Alzheimer"]
N0 -->|"regulates"| N1
N2["Neurodegeneration"]
N0 -->|"regulates"| N2
N3["Cancer"]
N0 -->|"regulates"| N3
N4["Als"]
N0 -->|"regulates"| N4
N5["Neuroinflammation"]
N0 -->|"regulates"| N5
N6["SNAP23"]
N0 -->|"regulates"| N6
N7["Autophagy"]
N0 -->|"regulates"| N7
N8["Microglia"]
N0 -->|"regulates"| N8
N9["HSP90"]
N9 -->|"regulates"| N0
N10["ALZHEIMER"]
N10 -->|"regulates"| N0
N11["SNAP29"]
N11 -->|"regulates"| N0
N12["MICROGLIA"]
N12 -->|"regulates"| N0
N13["LYSOSOME"]
N13 -->|"regulates"| N0
N14["STX4"]
N14 -->|"regulates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 disease
class N5 disease
class N6 gene
class N7 pathway
class N9 gene
class N10 gene
class N11 gene
class N12 gene
class N13 gene
class N14 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| SNAP23 | regulates | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| TH | interacts_with | gene | 0.60 |
| WDR45 | interacts_with | gene | 0.60 |
| XBP1 | interacts_with | gene | 0.60 |
| STX3 | regulates | gene | 0.60 |
| VTI1B | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Microglia | regulates | cell_type | 0.60 |
| SNARE | regulates | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSP90 | regulates | gene | 0.60 |
| SNAP29 | regulates | gene | 0.60 |
| STX4 | regulates | gene | 0.60 |
| STX3 | regulates | gene | 0.60 |
| FKBP5 | regulates | gene | 0.60 |
| RTN3 | interacts_with | gene | 0.60 |
| PARK7 | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| MICROGLIA | regulates | gene | 0.60 |
| LYSOSOME | regulates | gene | 0.60 |
| SKA2 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||