Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SNAP23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SNAP23 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Alzheimer, Ms. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | SNAP23 |
| Chromosome | 15q21.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | all neurons |
| Molecular Weight | 23 kDa |
| Exons | 6 |
| Pathways | Autophagy |
| Ensembl ID | ENSG00000100939 |
| GeneCards | SNAP23 |
| Human Protein Atlas | SNAP23 |
| N-terminal prefix | Regulatory function |
| SNARE motif (x3) | Core coiled-coil domain |
| C-terminal transmembrane | Membrane anchoring |
| Associated Diseases | neurodegeneration |
| Interactions | APP, TAU, ZBP1, BAX, HERC5, STX4 |
| KG Connections | 54 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SNAP23["<b>SNAP23</b>"]
Alzheimer{"Alzheimer"}
SNAP23 -->|"activates"| Alzheimer
Ms{"Ms"}
SNAP23 -->|"activates"| Ms
Autophagy(["Autophagy"])
SNAP23 -->|"activates"| Autophagy
APP["APP"]
SNAP23 -->|"activates"| APP
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
SNAP23 -->|"activates"| NEURODEGENERATIVE_DISEASES
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
SNAP23 -->|"activates"| ALZHEIMER_S_DISEASE
APP_PS1["APP/PS1"]
SNAP23 -->|"activates"| APP_PS1
TAU["TAU"]
SNAP23 -->|"activates"| TAU
AUTOPHAGY["AUTOPHAGY"]
SNAP23 -->|"activates"| AUTOPHAGY
NEUROTOXICITY["NEUROTOXICITY"]
SNAP23 -->|"activates"| NEUROTOXICITY
neurodegeneration["neurodegeneration"]
SNAP23 -->|"implicated in"| neurodegeneration
APP -->|"activates"| SNAP23
APP_PS1 -->|"activates"| SNAP23
style SNAP23 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| APP | activates | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| ZBP1 | activates | gene | 0.60 |
| BAX | activates | gene | 0.60 |
| HERC5 | activates | gene | 0.60 |
| STX4 | activates | gene | 0.60 |
| STX4 | inhibits | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| APP/PS1 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| NEUROTOXICITY | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Microglia | regulates | cell_type | 0.60 |
| RFK | inhibits | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| CHAC1 | activates | gene | 0.60 |
| Caspase | activates | protein | 0.60 |
| SNARE | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APP | activates | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| HSP90 | regulates | gene | 0.60 |
| SNAP29 | regulates | gene | 0.60 |
| STX4 | regulates | gene | 0.60 |
| STX3 | regulates | gene | 0.60 |
| FKBP5 | regulates | gene | 0.60 |
| SEC22B | regulates | gene | 0.60 |
| ISG15 | activates | gene | 0.60 |
| RAB8A | inhibits | gene | 0.60 |
| RAB8A | activates | gene | 0.60 |
| APP/PS1 | activates | gene | 0.60 |
| NEUROTOXICITY | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| LYSOSOME | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| MICROGLIA | regulates | gene | 0.60 |
| LYSOSOME | regulates | gene | 0.60 |
| SKA2 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| CMPK2 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||