Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STX4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
STX4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms, Parkinson. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | STX4 |
| Full Name | Syntaxin-4 |
| Chromosome | 16p12.1 |
| Function | STX4 encodes syntaxin-4, a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) family. |
| Subcellular Localization | intracellular compartments, STX4 is uniquely positioned at the plasma membrane, where it mediates exocytosis and maintai |
| Pathways | Autophagy |
| UniProt ID | Q12846 |
| NCBI Gene ID | 6814 |
| Ensembl ID | ENSG00000128415 |
| GeneCards | STX4 |
| Human Protein Atlas | STX4 |
| Associated Diseases | Als, Ms, Parkinson |
| Interactions | SNAP23, RAB8A, SNARE |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
STX4["<b>STX4</b>"]
Parkinson{"Parkinson"}
STX4 -->|"associated with"| Parkinson
Als{"Als"}
STX4 -->|"associated with"| Als
Ms{"Ms"}
STX4 -->|"associated with"| Ms
LDLR["LDLR"]
STX4 -->|"associated with"| LDLR
HSPB1["HSPB1"]
STX4 -->|"associated with"| HSPB1
APOA2["APOA2"]
STX4 -->|"associated with"| APOA2
LGALS3["LGALS3"]
STX4 -->|"associated with"| LGALS3
CSNK2A1["CSNK2A1"]
STX4 -->|"associated with"| CSNK2A1
NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
STX4 -->|"associated with"| NEURODEGENERATIVE_DISORDERS
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
STX4 -->|"associated with"| PARKINSON_S_DISEASE
PARKINSON["PARKINSON"]
STX4 -->|"associated with"| PARKINSON
AND["AND"]
STX4 -->|"associated with"| AND
PARKINSON_S_DISEASE -->|"associated with"| STX4
style STX4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| LDLR | associated_with | gene | 0.60 |
| APOA2 | associated_with | gene | 0.60 |
| LGALS3 | associated_with | gene | 0.60 |
| CSNK2A1 | associated_with | gene | 0.60 |
| STX3 | regulates | gene | 0.60 |
| FKBP5 | regulates | gene | 0.60 |
| SEC22B | regulates | gene | 0.60 |
| SNAP23 | regulates | gene | 0.60 |
| HSPB1 | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| SKA2 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Microglia | regulates | cell_type | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSP90 | regulates | gene | 0.60 |
| SNAP29 | regulates | gene | 0.60 |
| APOA2 | associated_with | gene | 0.60 |
| CSNK2A1 | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| LGALS3 | associated_with | gene | 0.60 |
| SNAP23 | activates | gene | 0.60 |
| RAB8A | inhibits | gene | 0.60 |
| SNAP23 | inhibits | gene | 0.60 |
| RAB8A | activates | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| MICROGLIA | regulates | gene | 0.60 |
| LYSOSOME | regulates | gene | 0.60 |
| HSPB1 | associated_with | gene | 0.60 |
| SNARE | activates | gene | 0.60 |
| STX17 | regulates | gene | 0.55 |
| STX1A | regulates | gene | 0.55 |
| SNARE | regulates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||