gene

STX4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STX4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections
0Hypotheses
0Analyses
25Outgoing
19Incoming

Summary

STX4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms, Parkinson. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSTX4
Full NameSyntaxin-4
Chromosome16p12.1
FunctionSTX4 encodes syntaxin-4, a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) family.
Subcellular Localizationintracellular compartments, STX4 is uniquely positioned at the plasma membrane, where it mediates exocytosis and maintai
PathwaysAutophagy
UniProt IDQ12846
NCBI Gene ID6814
Ensembl IDENSG00000128415
GeneCardsSTX4
Human Protein AtlasSTX4
Associated DiseasesAls, Ms, Parkinson
InteractionsSNAP23, RAB8A, SNARE
KG Connections44 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: STX4 — AlphaFold Q12846 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

STX4 — Syntaxin-4

gene · 606 words

Membrane Trafficking Pathway Dysfunction in Neurodegeneration

mechanism · 2788 words

STX2 — Syntaxin 2

gene · 2774 words

STX1A Gene - Syntaxin-1A

gene · 813 words

SNAP23 Gene

gene · 629 words

Genes

index · 271 words

Pathway Diagram

graph TD
    STX4["<b>STX4</b>"]
    Parkinson{"Parkinson"}
    STX4 -->|"associated with"| Parkinson
    Als{"Als"}
    STX4 -->|"associated with"| Als
    Ms{"Ms"}
    STX4 -->|"associated with"| Ms
    LDLR["LDLR"]
    STX4 -->|"associated with"| LDLR
    HSPB1["HSPB1"]
    STX4 -->|"associated with"| HSPB1
    APOA2["APOA2"]
    STX4 -->|"associated with"| APOA2
    LGALS3["LGALS3"]
    STX4 -->|"associated with"| LGALS3
    CSNK2A1["CSNK2A1"]
    STX4 -->|"associated with"| CSNK2A1
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    STX4 -->|"associated with"| NEURODEGENERATIVE_DISORDERS
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    STX4 -->|"associated with"| PARKINSON_S_DISEASE
    PARKINSON["PARKINSON"]
    STX4 -->|"associated with"| PARKINSON
    AND["AND"]
    STX4 -->|"associated with"| AND
    PARKINSON_S_DISEASE -->|"associated with"| STX4
    style STX4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

TargetRelationTypeStr
Parkinsonassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
Alzheimerregulatesdisease0.65
Neurodegenerationregulatesdisease0.65

Incoming (19)

SourceRelationTypeStr
HSP90regulatesgene0.60
SNAP29regulatesgene0.60
APOA2associated_withgene0.60
CSNK2A1associated_withgene0.60
LDLRassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found