Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about vti1b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | VTI1B |
| Protein Type | Receptor |
| Function | VTI1B is a vesicle-SNARE (v-SNARE) protein essential for intracellular membrane fusion events: |
| Molecular Weight | 23 kDa |
| Pathways | Apoptosis, Exocytosis, Mitochondrial Function, Complement |
| Ensembl ID | ENSG00000106052 |
| GeneCards | VTI1B |
| Human Protein Atlas | VTI1B |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
VTI1B["VTI1B"]
VTI1B -->|"regulates"| Dementia["Dementia"]
VTI1B -->|"regulates"| Schizophrenia["Schizophrenia"]
VTI1B -->|"regulates"| Alzheimer["Alzheimer"]
VTI1B -->|"regulates"| Multiple_Sclerosis["Multiple Sclerosis"]
VTI1B -->|"regulates"| Als["Als"]
VTI1B -->|"regulates"| Cancer["Cancer"]
VTI1B -->|"regulates"| Ms["Ms"]
VTI1B -->|"regulates"| EIF4G1["EIF4G1"]
NBN["NBN"] -->|"regulates"| VTI1B
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| VTI1B
SGK3["SGK3"] -->|"regulates"| VTI1B
TNF["TNF"] -->|"regulates"| VTI1B
CANCER["CANCER"] -->|"regulates"| VTI1B
SLC24A2["SLC24A2"] -->|"regulates"| VTI1B
APOPTOSIS["APOPTOSIS"] -->|"regulates"| VTI1B
DNAJC2["DNAJC2"] -->|"regulates"| VTI1B| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia | regulates | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| EIF4G1 | regulates | gene | 0.60 |
| NOX1 | regulates | gene | 0.60 |
| NGF | regulates | gene | 0.60 |
| DISC1 | regulates | gene | 0.60 |
| GALNT3 | regulates | gene | 0.60 |
| IREB2 | regulates | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Exocytosis | regulates | pathway | 0.60 |
| Mitochondrial Function | regulates | pathway | 0.60 |
| Complement | regulates | pathway | 0.60 |
| benchmark_ot_ad_answer_key:VTI1B | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NBN | regulates | gene | 0.60 |
| SGK3 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| SLC24A2 | regulates | gene | 0.60 |
| DNAJC2 | regulates | gene | 0.60 |
| CHMP3 | regulates | gene | 0.60 |
| PDE4C | regulates | gene | 0.60 |
| BAG1 | regulates | gene | 0.60 |
| PARK7 | regulates | gene | 0.60 |
| SEC22B | regulates | gene | 0.60 |
| STX3 | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| SNARE | regulates | gene | 0.60 |
| benchmark_ot_ad_answer_key:VTI1B | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||