gene

STAT5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

6Outgoing

15Incoming

0Experiments

0Debates

Summary

Comprehensive information on STAT5A, a JAK-STAT transcription factor critical for immune function, neuronal survival, and neurodegenerative disease pathogenesis.

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🧬 Gene Info

Gene Symbol	STAT5A
Full Name	Signal Transducer and Activator of Transcription 5A
Chromosome	12q13
Function	is a member of the STAT (Signal Transducer and Activator of Transcription) family of transcription factors.
Primary Expression	neurons and glia, where it serves important functions: [@stat5a_neurons_2016]
Molecular Weight	90 kDa
Amino Acids	793 aa
Exons	19
Pathways	JAK-STAT pathway
UniProt ID	P42229
NCBI Gene ID	6776
Ensembl ID	ENSG00000168661
OMIM	601711
GeneCards	STAT5A
Human Protein Atlas	STAT5A
Associated Diseases	neurodegeneration
Interactions	DLAT
KG Connections	21 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STAT5A — AlphaFold P42229 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STAT5A Gene

gene · 1428 words

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Pathway Diagram

graph TD
    STAT5A["<b>STAT5A</b>"]
    Als{"Als"}
    STAT5A -->|"expressed in"| Als
    APOPTOSIS["APOPTOSIS"]
    STAT5A -->|"expressed in"| APOPTOSIS
    BCL_2["BCL-2"]
    STAT5A -->|"regulates"| BCL_2
    Apoptosis(["Apoptosis"])
    STAT5A -->|"expressed in"| Apoptosis
    neurodegeneration["neurodegeneration"]
    STAT5A -->|"implicated in"| neurodegeneration
    DLAT["DLAT"]
    DLAT -->|"activates"| STAT5A
    JAK["JAK"]
    JAK -->|"expressed in"| STAT5A
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"expressed in"| STAT5A
    style STAT5A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
APOPTOSIS	expressed_in	gene	0.60
BCL-2	regulates	gene	0.60
Apoptosis	expressed_in	pathway	0.60
IFN	contributes_to	gene	0.60
Jak-Stat	contributes_to	pathway	0.60

Incoming (15)

Source	Relation	Type	Str
DLAT	activates	gene	0.70
JAK1	associated_with	gene	0.60
STAT6	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
STAT2	associated_with	gene	0.60
STAT4	associated_with	gene	0.60
JAK3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
JAK	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
JAK	associated_with	gene	0.60
AND	associated_with	gene	0.60
CYTOKINES	contributes_to	gene	0.60
GENES	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity