gene

STAT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

78Connections

0Hypotheses

0Analyses

45Outgoing

33Incoming

Summary

Page for STAT2 Gene - Signal Transducer and Activator of Transcription 2

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🧬 Gene Info

Gene Symbol	STAT2
Full Name	Signal Transducer and Activator of Transcription 2
Aliases	Page for STAT2 Gene
Chromosome	12q13.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	113 kDa
Amino Acids	130 aa
Pathways	JAK-STAT signaling
UniProt ID	P52630
NCBI Gene ID	6773
Ensembl ID	ENSG00000170581
GeneCards	STAT2
Human Protein Atlas	STAT2
Associated Diseases	neurodegeneration
Interactions	STAT1, IFNAR2, JAK, AUTOPHAGY, GENES, IFN
KG Connections	78 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STAT2 — AlphaFold P52630 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STAT2["<b>STAT2</b>"]
    Als{"Als"}
    STAT2 -->|"therapeutic target"| Als
    JAK["JAK"]
    STAT2 -->|"inhibits"| JAK
    NBR1["NBR1"]
    STAT2 -->|"regulates"| NBR1
    OPTN["OPTN"]
    STAT2 -->|"regulates"| OPTN
    AUTOPHAGY["AUTOPHAGY"]
    STAT2 -->|"activates"| AUTOPHAGY
    Autophagy(["Autophagy"])
    STAT2 -->|"activates"| Autophagy
    Jak_Stat(["Jak-Stat"])
    STAT2 -->|"inhibits"| Jak_Stat
    Innate_Immunity(["Innate Immunity"])
    STAT2 -->|"activates"| Innate_Immunity
    neurodegeneration["neurodegeneration"]
    STAT2 -->|"implicated in"| neurodegeneration
    E_protein["E protein"]
    E_protein -->|"inhibits"| STAT2
    OPTN -->|"inhibits"| STAT2
    NBR1 -->|"inhibits"| STAT2
    selective_autophagy(["selective autophagy"])
    selective_autophagy -->|"inhibits"| STAT2
    SADS_CoV_E_protein["SADS-CoV E protein"]
    SADS_CoV_E_protein -->|"inhibits"| STAT2
    VIRAL_INFECTIONS["VIRAL INFECTIONS"]
    VIRAL_INFECTIONS -->|"therapeutic target"| STAT2
    style STAT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Viral Infection	therapeutic_target	disease	0.65
Hepatitis	activates	disease	0.65
Infection	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
NBR1	regulates	gene	0.60
OPTN	regulates	gene	0.60
STAT4	associated_with	gene	0.60
JAK3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
STAT5A	associated_with	gene	0.60
STAT1	activates	gene	0.60
PSEN1	regulates	gene	0.60
IFNAR2	expressed_in	gene	0.60
TNF	regulates	gene	0.60
C1Q	regulates	gene	0.60
Rb	regulates	protein	0.60
JAK	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Jak-Stat	inhibits	pathway	0.60
Innate Immunity	activates	pathway	0.60
IFN	therapeutic_target	gene	0.60
GENES	contributes_to	gene	0.60
IFN	contributes_to	gene	0.60
Jak-Stat	contributes_to	pathway	0.60
GENES	activates	gene	0.60
IFN	activates	gene	0.60
Jak-Stat	activates	pathway	0.60
ASTROCYTES	regulates	gene	0.60
Jak-Stat	expressed_in	pathway	0.60
Astrocyte	regulates	cell_type	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
JAK	expressed_in	gene	0.60
ASTROCYTE	regulates	gene	0.60
Cytokine	regulates	protein	0.60
JAK-STAT signaling	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
Astrocyte	expressed_in	cell_type	0.55
IFNAR2	inhibits	gene	0.50

Incoming (33)

Source	Relation	Type	Str
E protein	inhibits	protein	0.90
OPTN	inhibits	protein	0.90
NBR1	inhibits	protein	0.90
selective autophagy	inhibits	pathway	0.90
SADS-CoV E protein	inhibits	protein	0.90
NBR1	regulates	gene	0.60
OPTN	regulates	gene	0.60
JAK1	associated_with	gene	0.60
STAT6	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
IFNAR2	expressed_in	gene	0.60
C1Q	regulates	gene	0.60
TNF	regulates	gene	0.60
PSEN1	regulates	gene	0.60
PSEN	expressed_in	gene	0.60
VIRAL INFECTIONS	therapeutic_target	gene	0.60
LYSOSOME	activates	gene	0.60
IFN	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
JAK	inhibits	gene	0.60
AND	regulates	gene	0.60
JAK	associated_with	gene	0.60
AND	associated_with	gene	0.60
CYTOKINES	contributes_to	gene	0.60
JAK	activates	gene	0.60
AND	activates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
JAK	expressed_in	gene	0.60
C1Q	activates	gene	0.50
PSEN1	activates	gene	0.50
ALZHEIMER	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STAT2

Understanding Entity Pages

Summary

Wiki Pages (21)

STAT2 Gene - Signal Transducer and Activator of Transcription 2

JAK-STAT Signaling Pathway in Neurodegeneration

IL28B (Interleukin 28B)

Interferon Signaling in Neurodegeneration

OPTN Protein (Optineurin)

IL28A (Interleukin-28A)

STAT4 Gene

TYK2 Protein — Tyrosine Kinase 2

Transcription Regulation Pathway

IFNAR2 — Interferon Alpha Receptor 2

IFNAR1 — Interferon Alpha Receptor 1

ISG15 — Interferon-Stimulated Gene 15

STAT5A Gene

il29

JAK-STAT Signaling Pathway in Neurodegeneration

MAPK/ERK and JAK-STAT Signaling in 4R-Tauopathies

STAT2 Protein

JAK/STAT Inhibitors for Neurodegeneration