DLAT

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive information about DLAT (Dihydrolipoamide S-Acetyltransferase), the E2 component of the pyruvate dehydrogenase complex essential for neuronal energy metabolism and implicated in Alzheimer's disease.

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graph TD
    DLAT["<b>DLAT</b>"]
    PKM2["PKM2"]
    DLAT -->|"interacts with"| PKM2
    copper["copper"]
    DLAT -->|"associated with"| copper
    autophagy["autophagy"]
    DLAT -->|"inhibits"| autophagy
    lipid_metabolism["lipid metabolism"]
    DLAT -->|"regulates"| lipid_metabolism
    SREBP1["SREBP1"]
    DLAT -->|"regulates"| SREBP1
    cuproptosis["cuproptosis"]
    DLAT -->|"participates in"| cuproptosis
    CaMKII["CaMKII"]
    DLAT -->|"regulates"| CaMKII
    CREB["CREB"]
    DLAT -->|"regulates"| CREB
    AMPK["AMPK"]
    DLAT -->|"activates"| AMPK
    mTOR["mTOR"]
    DLAT -->|"regulates"| mTOR
    JAK2["JAK2"]
    DLAT -->|"activates"| JAK2
    STAT5A["STAT5A"]
    DLAT -->|"activates"| STAT5A
    AKT["AKT"]
    AKT -->|"activates"| DLAT
    SLC31A1["SLC31A1"]
    SLC31A1 -->|"activates"| DLAT
    PER2["PER2"]
    PER2 -->|"activates"| DLAT
    HSP70["HSP70"]
    HSP70 -->|"activates"| DLAT
    CLOCK["CLOCK"]
    CLOCK -->|"activates"| DLAT
    ATF3["ATF3"]
    ATF3 -->|"activates"| DLAT
    style DLAT fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0