gene

STAT4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

30Outgoing

36Incoming

Summary

STAT4 (Signal Transducer and Activator of Transcription 4) is a transcription factor activated by IL-12, IL-23, and interferons. Critical for Th1/Th17 differentiation, neuroinflammation, and autoimmune diseases. Implicated in Alzheimer's disease, Parkinson's disease, and ALS.

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🧬 Gene Info

Gene Symbol	STAT4
Full Name	Signal Transducer and Activator of Transcription 4
Chromosome	2q32.2
Protein Type	Transcription Factor
Function	is a critical transcription factor that mediates signaling by interleukin-12 (IL-12), interleukin-23 (IL-23), and type I interferons.
Primary Expression	immune cells and, at lower levels, in various tissues including brain
Amino Acids	748 aa
Exons	24
Pathways	JAK-STAT signaling
UniProt ID	Q14765
NCBI Gene ID	6755
Ensembl ID	ENSG00000141510
OMIM	600556
GeneCards	STAT4
Human Protein Atlas	STAT4
Associated Diseases	neurodegeneration
Interactions	IL6, TLR4, GSH, FERROPTOSIS, TIMP1, PDGFRB
KG Connections	66 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STAT4["<b>STAT4</b>"]
    Ms{"Ms"}
    STAT4 -->|"interacts with"| Ms
    neurodegeneration["neurodegeneration"]
    STAT4 -->|"implicated in"| neurodegeneration
    IL6["IL6"]
    IL6 -->|"associated with"| STAT4
    TIMP1["TIMP1"]
    TIMP1 -->|"interacts with"| STAT4
    PDGFRB["PDGFRB"]
    PDGFRB -->|"interacts with"| STAT4
    IL23A["IL23A"]
    IL23A -->|"interacts with"| STAT4
    style STAT4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (30)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Ms	interacts_with	disease	0.65
Ferroptosis	activates	disease	0.65
Als	expressed_in	disease	0.65
JAK3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
STAT5A	associated_with	gene	0.60
MYD88	expressed_in	gene	0.60
NQO1	expressed_in	gene	0.60
JAK2	expressed_in	gene	0.60
STAT1	expressed_in	gene	0.60
GPX4	expressed_in	gene	0.60
IL6	activates	gene	0.60
KEAP1	expressed_in	gene	0.60
TLR4	inhibits	gene	0.60
ferroptosis	participates_in	pathway	0.60
GENES	contributes_to	gene	0.60
IFN	contributes_to	gene	0.60
Jak-Stat	contributes_to	pathway	0.60
GSH	activates	gene	0.60
HO-1	expressed_in	gene	0.60
FERROPTOSIS	activates	gene	0.60
Inflammasome	activates	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
JAK-STAT signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
benchmark_ot_ad_answer_key:STAT4	data_in	dataset_row	0.00

Incoming (36)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
IL6	associated_with	gene	0.60
TIMP1	interacts_with	gene	0.60
PDGFRB	interacts_with	gene	0.60
IL23A	interacts_with	gene	0.60
JAK1	associated_with	gene	0.60
STAT6	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
STAT2	associated_with	gene	0.60
TLR4	expressed_in	gene	0.60
TXNIP	expressed_in	gene	0.60
SLC40A1	expressed_in	gene	0.60
ASC	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
JAK1	expressed_in	gene	0.60
PCBP1	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
ASC	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
JAK1	inhibits	gene	0.60
JAK2	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
NQO1	inhibits	gene	0.60
PCBP1	inhibits	gene	0.60
SLC40A1	inhibits	gene	0.60
STAT1	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
JAK	associated_with	gene	0.60
AND	associated_with	gene	0.60
CYTOKINES	contributes_to	gene	0.60
ROS	activates	gene	0.60
COX2	inhibits	gene	0.60
IFN	regulates	gene	0.60
IFN	activates	gene	0.60
benchmark_ot_ad_answer_key:STAT4	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STAT4

Understanding Entity Pages

Summary

Wiki Pages (17)

STAT4 Gene

JAK-STAT Signaling Pathway in Neurodegeneration

Interferon Signaling in Neurodegeneration

Parabacteroides goldsteinii Mitigation of Parkinsonism in LRRK2 Mice

IL-12 Protein

IL23A Gene

Transcription Regulation Pathway

STAT5A Gene

JAK-STAT Signaling Pathway in Neurodegeneration

IL12A — Interleukin-12 Alpha

STAT2 Gene - Signal Transducer and Activator of Transcription 2

IL35 — Interleukin 35

IL12B Gene - Interleukin 12 Beta

JAK/STAT Inhibitors for Neurodegeneration

Signal Transducer and Activator of Transcription 4