concept

CEREBROSPINAL FLUID

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CEREBROSPINAL FLUID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

196Connections

0Hypotheses

0Analyses

31Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CEREBROSPINAL FLUID
Key Genes/Proteins	TAU, TDP-43, APOE, APP, BDNF
Related Diseases	AGING, ALZHEIMER

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CEREBROSPINAL_FLUID["CEREBROSPINAL FLUID"]
    CEREBROSPINAL_FLUID -->|"interacts"| TAU["TAU"]
    CEREBROSPINAL_FLUID -->|"component_of"| Amyloid_beta_1_42["Amyloid-beta 1-42"]
    CEREBROSPINAL_FLUID -->|"component_of"| Tau_Protein["Tau Protein"]
    CEREBROSPINAL_FLUID -->|"component_of"| Glymphatic_Pathway["Glymphatic Pathway"]
    CEREBROSPINAL_FLUID -->|"mediates"| __amyloid["beta-amyloid"]
    CEREBROSPINAL_FLUID -->|"interacts"| NEURODEGENERATION["NEURODEGENERATION"]
    AMYLOID["AMYLOID"] -.biomarker for.-> CEREBROSPINAL_FLUID
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -.biomarker for.-> CEREBROSPINAL_FLUID
    YKL_40["YKL-40"] -->|"expressed in"| CEREBROSPINAL_FLUID
    TAU -->|"expressed in"| CEREBROSPINAL_FLUID
    Cryptic_HDGFL2["Cryptic HDGFL2"] -->|"expressed in"| CEREBROSPINAL_FLUID
    __SYNUCLEIN["Alpha-SYNUCLEIN"] -->|"expressed in"| CEREBROSPINAL_FLUID
    __Synuclein["alpha-Synuclein"] -.biomarker for.-> CEREBROSPINAL_FLUID
    __synuclein["alpha-synuclein"] -->|"expressed in"| CEREBROSPINAL_FLUID

Outgoing (37)

Target	Relation	Type	Str
MICROGLIA	biomarker_for	cell_type	0.65
TAU	phosphorylates	protein	0.65
AGING	interacts_with	phenotype	0.65
TAU	activates	protein	0.60
TDP-43	phosphorylates	gene	0.60
TDP-43	treats	gene	0.60
ASTROCYTE	activates	cell_type	0.60
TAU	treats	protein	0.60
TAU	stabilizes	protein	0.60
APOE	treats	gene	0.60
APP	stabilizes	gene	0.60
BDNF	stabilizes	gene	0.60
NEUROFILAMENT LIGHT	stabilizes	biomarker	0.60
BDNF	protects_against	gene	0.60
MICROGLIAL ACTIVATION	stabilizes	phenotype	0.60
AMYLOID	stabilizes	protein	0.60
AMYLOID	treats	protein	0.60
CYTOKINES	depleted_in	phenotype	0.55
CELL MIGRATION	regulates	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	expressed_in	concept	0.50
ENTORHINAL CORTEX	associated_with	brain_region	0.50
NICOTINAMIDE	associated_with	drug	0.50
L-DOPA	associated_with	drug	0.50
RETINA	associated_with	brain_region	0.45
AMYLOID PET	associated_with	biomarker	0.45
NEUROFILAMENT LIGHT	associated_with	biomarker	0.45
SPINAL CORD	associated_with	brain_region	0.45
MOTOR CORTEX	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45

Incoming (159)

Source	Relation	Type	Str
TAU	produces	protein	0.65
ALZHEIMER	regulates	disease	0.65
CHOROID PLEXUS	produces	cell_type	0.65
INFLAMMATION	synergizes_with	phenotype	0.60
AQP4	stabilizes	gene	0.60
AGING	inhibits	phenotype	0.60
HK2	stabilizes	gene	0.60
HK2	inhibits	gene	0.60
NEURODEGENERATION	causes	phenotype	0.60
NEURODEGENERATION	destabilizes	phenotype	0.60
CHOROID PLEXUS	activates	cell_type	0.60
NEURODEGENERATION	stabilizes	phenotype	0.60
ALTERNATIVE SPLICING	expressed_in	phenotype	0.55
AQP4	implicated_in	gene	0.55
NEURODEGENERATION	expressed_in	phenotype	0.55
ALZHEIMER	expressed_in	disease	0.55
NEURODEGENERATION	implicated_in	phenotype	0.55
CHOROID PLEXUS	implicated_in	cell_type	0.55
IGF2	interacts_with	gene	0.50
ALZHEIMER	interacts_with	gene	0.50
PARKINSON	interacts_with	gene	0.50
amyotrophic lateral sclerosis	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
HUNTINGTON	interacts_with	gene	0.50
Parkinson's Disease	interacts_with	disease	0.50
HUNTINGTON'S DISEASE	interacts_with	concept	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
PARKINSON'S	interacts_with	concept	0.50
HUNTINGTON'S	interacts_with	concept	0.50
DEMENTIA	associated_with	gene	0.50
GBA1	activates	gene	0.50
TFR1	activates	gene	0.50
PARKINSON	activates	gene	0.50
Parkinson's Disease	activates	disease	0.50
disease	activates	disease	0.50
PARKINSON'S	activates	concept	0.50
APOE4	inhibits	gene	0.50
TAU PATHOLOGY	inhibits	concept	0.50
Cognitive Impairment	inhibits	phenotype	0.50
AMYLOID-β	inhibits	concept	0.50
APOE4	activates	gene	0.50
AMYLOID	activates	gene	0.50
PERICYTE	activates	concept	0.50
Cognitive Decline	activates	disease	0.50
AMYLOID-β	activates	concept	0.50
Neuroinflammatory	associated_with	pathway	0.50
disease	associated_with	disease	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CEREBROSPINAL FLUID

Understanding Entity Pages

Wiki Pages (20)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

NPM1 Gene

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

NRF2 Oxidative Stress Pathway

Multiple System Atrophy