protein

NPTX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPTX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

199Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

NPTX2 is a protein involved in neurodegeneration research. Key relationships include: regulates, inhibits, implicated in. Associated with AD, ALI, Alzheimer. Connected to 86 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolNPTX2
Full NameNeuronal Pentraxin 2
FunctionNeuronal Pentraxin 2 (NPTX2), also known as neuronal activity-regulated pentraxin (NARP), is a member of the pentraxin family of calcium-dependent ligand-binding proteins.
Molecular Weight47 kDa
PathwaysCOMPLEMENT, Complement
Ensembl IDENSG00000106290
GeneCardsNPTX2
Human Protein AtlasNPTX2
Associated DiseasesAD, ALI, ALS, Alzheimer, Alzheimer'S Disease
InteractionsMET, WIF1, TAU, C1Q, NLGN1, NTN1
KG Connections199 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NPTX2 — Neuronal Pentraxin 2

gene · 532 words

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

mechanism · 4322 words

Biomarker Rankings

biomarker · 3473 words

Adult Neurogenesis in Neurodegenerative Disease

mechanism · 3124 words

mossy-cells-dentate-gyrus

cell_type · 2831 words

Microglia and neuroinflammation in Alzheimer's Disease

mechanism · 2789 words

Pathway Diagram

flowchart TD
    NPTX2["NPTX2"] -->|"interacts with"| C1Q["C1Q"]
    NPTX2["NPTX2"] -->|"regulates"| COMPLEMENT["COMPLEMENT"]
    NPTX2["NPTX2"] -->|"biomarker for"| Alzheimer["Alzheimer"]
    NPTX2["NPTX2"] -->|"biomarker for"| Ms["Ms"]
    NPTX2["NPTX2"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    NPTX2["NPTX2"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    NPTX2["NPTX2"] -->|"regulates"| Dementia["Dementia"]
    NPTX2["NPTX2"] -->|"regulates"| Inflammation["Inflammation"]
    NPTX2["NPTX2"] -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    NPTX2["NPTX2"] -->|"regulates"| Alzheimer["Alzheimer"]
    NPTX2["NPTX2"] -->|"associated with"| Alzheimer["Alzheimer"]
    NPTX2["NPTX2"] -->|"regulates"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    style NPTX2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style C1Q fill:#006494,stroke:#333,color:#e0e0e0
    style COMPLEMENT fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Frontotemporal_Dementia fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (134)

TargetRelationTypeStr
C1Qbindsprotein0.95
Complement Activityinhibitsprocess0.95
Complement Activationinhibitsprocess0.95
Complement Activityregulatesprocess0.95
Excitatory Synapse Lossprotects_againstphenotype0.90

Incoming (65)

SourceRelationTypeStr
VGFassociated_withgene0.60
NTN1associated_withgene0.60
GPNMBassociated_withgene0.60
WIF1inhibitsgene0.60
C1Qactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found