Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CASPASE-8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CASPASE |
| GeneCards | CASPASE |
| Human Protein Atlas | CASPASE |
| Associated Diseases | Fibrosis, Cancer, Als, Aging, Lymphoma, Neurodegeneration |
| Interactions | RIPK1, CASPASE-6, RIPK3, CHMP4B, CASPASE-3, FADD |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CASPASE-8"]
N1["PARP1"]
N0 -->|"co discussed"| N1
N2["RIPK1"]
N0 -->|"activates"| N2
N3["CASPASE-6"]
N0 -->|"inhibits"| N3
N4["apoptosis"]
N0 -->|"activates"| N4
N5["inflammation"]
N0 -->|"protects against"| N5
N0 -->|"activates"| N5
N6["CELL DEATH"]
N0 -->|"activates"| N6
N7["GSDMD"]
N0 -->|"associated with"| N7
N8["INFLAMMASOME"]
N0 -->|"associated with"| N8
N9["Astrocytes"]
N0 -->|"associated with"| N9
N10["Neuron"]
N0 -->|"associated with"| N10
N11["NEURONS"]
N0 -->|"associated with"| N11
N12["TUMOR"]
N0 -->|"inhibits"| N12
N13["Necroptosis"]
N0 -->|"inhibits"| N13
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N2 gene
class N3 protein
class N5 pathway
class N7 protein
class N12 disease
class N13 pathway| Target | Relation | Type | Str |
|---|---|---|---|
| PARP1 | co_discussed | gene | 0.50 |
| RIPK1 | activates | gene | 0.50 |
| CASPASE-6 | inhibits | protein | 0.50 |
| apoptosis | activates | process | 0.50 |
| inflammation | protects_against | pathway | 0.50 |
| inflammation | activates | pathway | 0.50 |
| CELL DEATH | activates | concept | 0.50 |
| GSDMD | associated_with | protein | 0.50 |
| Astrocytes | associated_with | cell_type | 0.50 |
| Neuron | associated_with | cell_type | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| TUMOR | inhibits | disease | 0.50 |
| Necroptosis | inhibits | pathway | 0.50 |
| T Cell | inhibits | cell_type | 0.50 |
| Necroptosis | activates | pathway | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||