SMAC

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SMAC is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, therapeutic target. Associated with Aging, Als, Ataxia. Connected to 51 entities in the SciDEX knowledge graph.

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graph TD
    SMAC["<b>SMAC</b>"]
    Als{"Als"}
    SMAC -->|"activates"| Als
    Ms{"Ms"}
    SMAC -->|"interacts with"| Ms
    Aging{"Aging"}
    SMAC -->|"activates"| Aging
    SMAC -->|"inhibits"| Ms
    Tumor{"Tumor"}
    SMAC -->|"activates"| Tumor
    Glioblastoma{"Glioblastoma"}
    SMAC -->|"associated with"| Glioblastoma
    SMAC -->|"regulates"| Ms
    Stroke{"Stroke"}
    SMAC -->|"regulates"| Stroke
    Neurodegeneration{"Neurodegeneration"}
    SMAC -->|"regulates"| Neurodegeneration
    SMAC -->|"activates"| Ms
    Ataxia{"Ataxia"}
    SMAC -->|"activates"| Ataxia
    LC3["LC3"]
    SMAC -->|"activates"| LC3
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"interacts with"| SMAC
    DIABLO["DIABLO"]
    DIABLO -->|"interacts with"| SMAC
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| SMAC
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| SMAC
    HTRA2["HTRA2"]
    HTRA2 -->|"interacts with"| SMAC
    MICROGLIA_ACTIVATION["MICROGLIA ACTIVATION"]
    MICROGLIA_ACTIVATION -->|"activates"| SMAC
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"associated with"| SMAC
    CD8["CD8"]
    CD8 -->|"activates"| SMAC
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| SMAC
    E2F1["E2F1"]
    E2F1 -->|"regulates"| SMAC
    P53["P53"]
    P53 -->|"regulates"| SMAC
    MYC["MYC"]
    MYC -->|"regulates"| SMAC
    style SMAC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0