protein

NEMO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEMO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

78Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

Summary

NEMO is a protein involved in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Connected to 15 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NEMO
Protein Family	IKK kinase complex
Protein Type	Kinase
Function	NEMO (IKKγ) is the regulatory subunit of the IKK complex.
Molecular Weight	48 kDa
Pathways	NF-kB signaling, NF-κB signaling, oxidative stress response
UniProt ID	[Q9Y578](https://www.uniprot.org/uniprot/Q9Y578)
GeneCards	NEMO
Human Protein Atlas	NEMO
Associated Diseases	neurodegeneration
Interactions	PARKIN, P62, OPTN, OPTINEURIN, NF-ΚB, OXIDATIVE STRESS
KG Connections	78 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NEMO["<b>NEMO</b>"]
    damaged_mitochondria["damaged mitochondria"]
    NEMO -->|"interacts with"| damaged_mitochondria
    IKK2["IKK2"]
    NEMO -->|"activates"| IKK2
    NF_kB_signaling(["NF-kB signaling"])
    NEMO -->|"activates"| NF_kB_signaling
    IKK["IKK"]
    NEMO -->|"associated with"| IKK
    SQSTM1["SQSTM1"]
    NEMO -->|"interacts with"| SQSTM1
    NEMO -->|"activates"| IKK
    OPTN["OPTN"]
    NEMO -->|"associated with"| OPTN
    protein["protein"]
    NEMO -->|"interacts with"| protein
    NF__B_signaling(["NF-kappaB signaling"])
    NEMO -->|"activates"| NF__B_signaling
    neurodegeneration["neurodegeneration"]
    NEMO -->|"implicated in"| neurodegeneration
    PRKN["PRKN"]
    PRKN -->|"associated with"| NEMO
    Parkin["Parkin"]
    Parkin -->|"regulates"| NEMO
    SQSTM1 -->|"interacts with"| NEMO
    PRKN -->|"regulates"| NEMO
    oxidative_stress(["oxidative stress"])
    oxidative_stress -->|"activates"| NEMO
    style NEMO fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

Target	Relation	Type	Str
Damaged Mitochondria	binds	process	0.95
damaged mitochondria	interacts_with	phenotype	0.90
IKK2	activates	protein	0.90
Ikbkg	associated_with	entity	0.90
NF-kB signaling	activates	pathway	0.90
IKK	associated_with	protein	0.90
SQSTM1	interacts_with	protein	0.80
damaged mitochondria	co_localizes	organelle	0.80
p62/SQSTM1	co_localizes	protein	0.80
phospho-IKKβ	recruits	protein	0.80
Astrocyte	expressed_in	cell_type	0.80
OPTN	associated_with	protein	0.70
protein	interacts_with	entity	0.70
NF-κB signaling	activates	pathway	0.70
IKK	activates	protein	0.70
Aging	contributes_to	disease	0.65
OPTINEURIN	regulates	entity	0.60
OPTN	regulates	entity	0.60
PARKIN	regulates	entity	0.60
OPTN	expressed_in	entity	0.60
P62	expressed_in	entity	0.60
SQSTM1	expressed_in	entity	0.60
PARKIN	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
neuroinflammation	interacts_with	disease	0.60
NF-ΚB	interacts_with	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
Neuroinflammatory	interacts_with	pathway	0.60
Oxidative Stress	interacts_with	pathway	0.60
Mitophagy	interacts_with	pathway	0.60
Nf-Κb	interacts_with	pathway	0.60
CYTOKINES	interacts_with	gene	0.60
Astrocyte	interacts_with	cell_type	0.60
T Cell	contributes_to	cell_type	0.60
Cytokine	interacts_with	protein	0.60
Ubiquitin	interacts_with	protein	0.60
App	interacts_with	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
PAP	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
NF-κB	activates	concept	0.50

Incoming (21)

Source	Relation	Type	Str
PRKN	mediates	gene	0.95
PRKN	associated_with	gene	0.90
Parkin	regulates	protein	0.80
Oxidative Stress	activates	process	0.80
SQSTM1	interacts_with	protein	0.70
PRKN	regulates	protein	0.70
oxidative stress	activates	process	0.70
OPTN	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
IKBKG	regulates	gene	0.60
IKBKG	activates	gene	0.60
LC3	interacts_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
IKK	activates	gene	0.60
PARKIN	interacts_with	gene	0.50
P62/SQSTM1	interacts_with	protein	0.50
IKKΒ	activates	protein	0.50
MITOPHAGY	regulates	process	0.30
CYTOKINES	activates	protein	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NEMO

Understanding Entity Pages

Summary

Wiki Pages (21)

NEMO/IKKγ Protein

NF-kB Signaling Pathway in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

UBE2V1 Gene (UEV-1)

nfkb-neurodegeneration

OTULIN-Tau Regulation Pathway

Kinesin-1 Heavy Chain Protein

PAK2 Protein (p21-Activated Kinase 2)

Beta-Synuclein Protein

NF-κB Signaling in Neurodegeneration

Gemin-6 Protein

ATF3 Protein

Vagus Nerve Stimulation for Parkinson's Disease

LTBR Gene

CYLD Protein — Lysine-Specific Deubiquitinase in Neurodegeneration

OPTN Protein (Optineurin)

S100 Protein Signaling Pathway in Neurodegeneration

SQSTM1 — Sequestosome 1 (p62)

NF-κB Pathway Inhibition for Neurodegeneration