The abstract presents a bidirectional relationship where glucose impairment increases AD risk and tau loss, while tau dysfunction may contribute to glucose alterations. The directionality of this relationship remains unresolved, which is crucial for therapeutic targeting. Gap type: open_question Source paper: Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model. (None, None, PMID:35250480)
Landscape Summary: Does tau dysfunction cause glucose homeostasis impairment or vice versa in AD pathogenesis? is a 0.76 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Does tau dysfunction cause glucose homeostasis impairment or vice versa in AD pathogenesis? — INVOKE-2 (completed)
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