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Perivascular spaces and glymphatic clearance failure in AD

PARTIALLY ADDRESSED

Perivascular spaces and glymphatic clearance failure in AD

Priority: 0.87 Domain: neurodegeneration Hypotheses: 8
📊 Landscape Analysis

Landscape Summary: Perivascular spaces and glymphatic clearance failure in AD is a 0.87 priority gap in neurodegeneration. It has 8 linked hypotheses with average composite score 0.000. Status: partially_addressed.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

Perivascular spaces and glymphatic clearance failure in AD — INVOKE-2 (completed)

📈 Living Dashboards
8
Hypotheses
0.000
Top Score
0.000
Avg Score
1
Debates
0.95
Avg Quality
60%
Resolution
0
Mechanistic Families
Gap Resolution Progress60%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)
Perivascular Inflammation Resolution Therapy
Target: TREM2, AQP4, C1QA Pathway: N/A
0.000
score
Dual Proteinopathy Clearance via Enhanced Drainage
Target: ACTA2, PDGFRB, PROX1 Pathway: N/A
0.000
score
Arteriolosclerosis-Targeted Perivascular Space Restoration
Target: ACTA2, COL4A1, MMP9 Pathway: N/A
0.000
score
Anti-CAA Immunotherapy for Glymphatic Rescue
Target: APP, PSEN1, C1QA Pathway: N/A
0.000
score
Circadian Melatonin Therapy for Glymphatic Enhancement
Target: MTNR1A, MTNR1B, CLOCK, ARNTL Pathway: N/A
0.000
score
Sleep Architecture Optimization via Glymphatic Pacing
Target: GABRA1, ADORA1, ADRA2A Pathway: N/A
0.000
score
Chronotherapeutic Glymphatic Enhancement
Target: CLOCK, ARNTL, PER2, CRY1 Pathway: N/A
0.000
score
🌊 Knowledge Graph Connections

associated with (21)

entities-ros→ADentities-histone-methylation→ADentities-atp7b-gene→ADTAU→ADTDP-43→AD
▸ Show 16 more

biomarker for (1)

tau cleavage products→AD

causes (6)

AD→neurodegenerationPHOSPHORYLATED_TAU→ADBETA_AMYLOID→ADAD→IMMUNE_TOLAD→memory_loss
▸ Show 1 more

contributes to (1)

NEUROINFLAMMATION→AD

cross disease mechanism in (5)

MAPT→ADTREM2→ADNLRP3→ADPINK1→ADGRN→AD

depleted in (1)

SPM_levels→AD

prevents (1)

NAD+ augmentation→AD

protective against (1)

cognitive stimulation→AD

regulates (1)

AD→PROTEOME

risk factor for (4)

genetically at-risk individuals→ADAPOE ε4→ADmicroglial priming→ADAPOE4→AD

targets (1)

resveratrol→AD

therapeutic target for (6)

TREM2→ADCCR2→ADSaracatinib→ADanti-amyloid antibodies→ADNAD+ augmentation→AD
▸ Show 1 more

treats (1)

HTL9936→AD
🕑 Activity Feed
📈 Perivascular Inflammation Resolution Therapy score=0.000 2026-04-28T21:58
📈 Dual Proteinopathy Clearance via Enhanced Drainage score=0.000 2026-04-28T21:58
📈 Arteriolosclerosis-Targeted Perivascular Space Restoration score=0.000 2026-04-28T21:58
📈 Anti-CAA Immunotherapy for Glymphatic Rescue score=0.000 2026-04-28T21:58
📈 Circadian Melatonin Therapy for Glymphatic Enhancement score=0.000 2026-04-28T21:58
🎭 Perivascular spaces and glymphatic clearance failure in AD q=0.95 2026-04-06T18:19
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