| Gene Symbol | CHRNA7 |
| Chromosome | 15q13.3 |
| Protein Type | Channel |
| Target Class | Protein |
| Function | The nicotinic acetylcholine receptor alpha 7 (α7 nAChR) is a homomeric ligand-gated ion channel highly expressed in the brain, particularly in the hippocampus, cortex, and basal ganglia. |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication |
| Primary Expression | the brain, particularly in the hippocampus, cortex, and basal ganglia |
| Druggability | Undruggable (0.23) |
| Amino Acids | 502 aa |
| Exons | 10 |
| Pathways | NF-κB, MAPK |
| Ensembl ID | ENSG00000175344 |
| GeneCards | CHRNA7 |
| Human Protein Atlas | CHRNA7 |
| Extracellular N-terminal domain | Contains the ligand-binding site at the interface between subunits |
| Associated Diseases | Als, Alzheimer, bipolar disorder, cancer, COLORECTAL CANCER |
| Known Drugs/Compounds | valproic acid |
| Interactions | ABCB1, AD, Akt, AKT, AKT1, ALZHEIMER |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Enhancing Vagal Cholinergic Signaling to Restore G Cholinergic Attention Modulation Hypothesis |
| KG Connections | 437 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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