HNRNPA2B1

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNRNPA2B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for HNRNPA2B1 - Heterogeneous Nuclear Ribonucleoprotein A2/B1

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flowchart TD
    HNRNPA2B1["HNRNPA2B1<br/>RNA-binding protein<br/>Ribonucleoprotein"]
    
    %% RNA Processing & Associated Proteins
    HNRNPA1["HNRNPA1<br/>RNA-binding protein"]
    IGF2BP1["IGF2BP1<br/>RNA-binding protein"]
    VALOSIN["VCP/VALOSIN<br/>Protein processing"]
    
    %% Signaling Pathways
    NOTCH1["NOTCH1<br/>Transcription factor"]
    NotchPath["Notch Signaling<br/>Pathway"]
    CSNK2A1["CSNK2A1<br/>Casein kinase"]
    EpiPath["Epigenetic<br/>Regulation"]
    
    %% Neurodegenerative Diseases
    ALS["Amyotrophic Lateral<br/>Sclerosis (ALS)"]
    FTD["Frontotemporal<br/>Dementia"]
    ALZ["Alzheimer's<br/>Disease"]
    MS["Multiple<br/>Sclerosis"]
    Dementia["Dementia<br/>General"]
    NeuroDegeneration["Neurodegeneration<br/>Process"]
    
    %% Inflammatory Process
    Inflammation["Neuroinflammation<br/>Process"]
    
    %% Connections
    HNRNPA2B1 --|"associates with"|--> HNRNPA1
    HNRNPA2B1 --|"interacts with"|--> IGF2BP1
    HNRNPA2B1 --|"associates with"|--> VALOSIN
    
    HNRNPA2B1 --|"activates"|--> CSNK2A1
    HNRNPA2B1 --|"activates"|--> NOTCH1
    HNRNPA2B1 --|"activates"|--> NotchPath
    HNRNPA2B1 --|"inhibits"|--> EpiPath
    
    HNRNPA2B1 --|"activates"|--> ALS
    HNRNPA2B1 --|"activates"|--> ALZ
    HNRNPA2B1 --|"associated with"|--> FTD
    HNRNPA2B1 --|"activates"|--> MS
    HNRNPA2B1 --|"associated with"|--> Dementia
    HNRNPA2B1 --|"activates"|--> NeuroDegeneration
    
    HNRNPA2B1 --|"regulates"|--> Inflammation
    Inflammation --|"contributes to"|--> NeuroDegeneration
    
    NotchPath --|"promotes"|--> NeuroDegeneration
    CSNK2A1 --|"phosphorylates"|--> HNRNPA2B1
    
    %% Styling
    style HNRNPA2B1 fill:#006494
    style HNRNPA1 fill:#4a1a6b
    style IGF2BP1 fill:#4a1a6b
    style VALOSIN fill:#4a1a6b
    style NOTCH1 fill:#4a1a6b
    style NotchPath fill:#ef5350
    style CSNK2A1 fill:#4a1a6b
    style EpiPath fill:#1b5e20
    style ALS fill:#5d4400
    style FTD fill:#5d4400
    style ALZ fill:#5d4400
    style MS fill:#5d4400
    style Dementia fill:#5d4400
    style NeuroDegeneration fill:#ef5350
    style Inflammation fill:#ef5350