protein 946 words KG: UBIQUITINPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Ubiquitin Protein

🔬 Protein Info
Gene SymbolUBIQUITIN
AliasesUBIQUITINPROTEIN
Functionis a highly conserved 76-amino acid protein that covalently attaches to target proteins to mark them for various cellular fates.
Subcellular Localization</th><td>Cytoplasm, Nucleus, Mitochondria, Membrane</td></tr>
PathwaysAdaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy
GeneCardsUBIQUITIN
Human Protein AtlasUBIQUITIN
Associated DiseasesALS, Aging, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsproteolysis-targeting chimeras, RAPAMYCIN
InteractionsDDB1, ATG12, ATG16L1, ATG5, P62, KEAP1
KG Connections4017 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (24)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (14)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (5)

Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Prion Strain Diversity and Selective Vulnerability in CJD
clinical · proposed · Score: 0.40
Proteasome-Ubiquitin System Dysfunction Validation in Parkin
clinical · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 15 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 15 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 15 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 15 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 15 hypotheses